Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Gül, Abdulkadir(4)
- Aydoğmuş, Ercan(3)
- Topal, Fevzi(2)
- Yıldırım, Aybeniz(2)
- Özgen, İnanç(2)
- Akyıldız, Esma(1)
- Arslanoglu, Hasan(1)
- Arslanoğlu, Hasan(1)
- Aydemir, Eda(1)
- Aydogmus, Ercan(1)
- Baltaci, Cemalettin(1)
- Baltacı, Cemalettin(1)
- Bulut Atalay, Esra(1)
- Camadan, Yasemin(1)
- Celep, İnci Kurt(1)
- Demirel, Maruf Hurşit(1)
- Gül, Abdulkadi̇R(1)
- Gül, Esra(1)
- Güzel, Emre(1)
- Karan, Halil(1)
- Karpuz, Ömer(1)
- Kobya, Havva Nur(1)
- Koçyiğit, Ümit Muhammet(1)
- Saral Sarıyer, Ayşegül(1)
- Sarıyer, Emrah(1)
- Topal, Meryem(1)
- Yilmaz, Firat(1)
- Yilmaz, Fırat(1)
- Yılmaz, Fırat(1)
- Öner, İLyas(1)
- Özad Düzgün, Azer(1)
- Özgen, Inanc(1)
- Özgen, İNanç(1)
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ1Antibacterial efficacy of pyrolysis-derived plant fractions against resistant pathogens: a comparative evaluation using nutrient and Müller–Hinton agar
Demirel, Maruf Hurşit; Gül, Abdulkadir; Aydoğmuş, Ercan; Özgen, İnanç; Arslanoğlu, Hasan
BACKGROUND: This study investigates the antibacterial potential of pyrolysis-derived extracts from rosehip fruit (RF), orange peel (OP), corn silk (CS), spurge root (ER) and mullein leaf (ML) against antibiotic-resistant pathogens using two different culture media. Bioactive compounds were obtained via a PID-controlled pyrolysis system, and antibacterial activity was evaluated to clarify both extract efficacy and medium-dependent effects on bacterial growth and diffusion. RESULTS: Antibacterial activities were assessed using the agar well diffusion method, with ampicillin as a positive control, against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus faecalis. A key novelty of this work is the comparative evaluation of extract performance on nutrient agar (NA) and Müller–Hinton agar (MHA). Among all samples, the ML extract exhibited the strongest antibacterial activity across all tested strains, producing inhibition zones of 18.85 mm against E. coli and 17.15 mm against E. faecalis on NA, compared with 13.05 mm and 13.60 mm on MHA, respectively. CS and ER extracts showed moderate antibacterial effects, with consistently higher inhibition zones on NA than on MHA. Ampicillin generated substantially larger inhibition zones on NA (33.35 mm for E. coli and 34.45 mm for P. aeruginosa) compared with MHA (13.80 and 27.70 mm, respectively), confirming the strong influence of culture medium composition on measurable antibacterial activity. CONCLUSION: These results indicate that both plant extracts and ampicillin exhibit higher antibacterial activity on NA than on MHA. The pronounced efficacy of the ML extract highlights pyrolysis-derived plant fractions as promising natural antimicrobials and emphasizes the critical importance of culture medium selection.
AtıfScopus4WoS5OpenAlex5İncele - MakaleAçık Erişim2026Scopus SJRQ3Green-synthesis of iron nanoparticles using wild cherry laurel (Prunus laurocerasus L.) fruit extract and their patulin and HMF adsorption capacities along with biological activities
Kobya, Havva Nur; Gül, Esra; Karpuz, Ömer; Baltacı, Cemalettin
In this study, iron nanoparticles (YBFeNPs) were green-synthesized using the aqueous extract (YB-E) of wild cherry laurel (Prunus laurocerasus L.) fruit to evaluate their potential applications in food safety. The synthesized YBFeNPs were investigated through Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and energy-dispersive X-ray spectroscopy analyses. YBFeNPs showed higher total phenolic content, total flavonoid content, and total antioxidant capacity compared to the original extract, suggesting that plant metabolites enhance NP bioactivity. Antioxidant capacity was further validated by DPPH, ABTS, and FRAP assays, which demonstrated strong radical scavenging and reducing power. The antibacterial activity of YBFeNPs was assessed against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Enterococcus faecalis, revealing concentration-dependent effects with the highest inhibition zone of 14.5 ± 0.4 mm for E. coli. The chemical composition of the YB-E extract was analyzed using liquid chromatography-tandem mass spectrometry, identifying quinic acid, a polyol, and phenolic compounds such as chlorogenic acid (1.45 mg/g) and naringenin (0.02 mg/g). Additionally, the adsorption capacities of YBFeNPs were investigated against patulin and hydroxymethylfurfural (HMF), toxic compounds posing significant threats to food safety. The NPs demonstrated effective adsorption of both patulin and HMF, achieving maximum adsorption rates of 61.05% and 46.12%, respectively, at a concentration of 5.0 g/L after 240 min.
AtıfScopus4WoS4OpenAlex4İncele - MakaleAçık Erişim2026Scopus SJRQ1Thermochemical Valorization of Silkworm Feeding Waste: Chemical Characterization and Biological Activities of the Pyrolysis-Derived Liquid Fraction
Karan, Halil; Yıldırım, Aybeniz; Yılmaz, Fırat; Özgen, İnanç; Aydoğmuş, Ercan; Gül, Abdulkadir
Silkworm-rearing residues are an underused biomass resource that can be converted into value-added products. In this study, a condensable liquid product (SWP-Liq) was produced from these residues by pyrolysis at 325 ± 5 °C and evaluated for its chemical composition and in vitro biological activities. SWP-Liq yielded phenolic-, flavonoid-, and triterpenoid-equivalent values of 218.47 ± 22.40 mg GAE/g, 79.13 ± 3.55 mg QE/g, and 55.54 ± 6.15 mg EE/g, respectively. The ABTS•+ assay showed a higher radical-scavenging response than DPPH, while Fe3+- and Cu2+-reducing activities were also observed. SWP-Liq inhibited 5-LOX with an IC50 of 33.05 ± 1.10 µg/mL, whereas α-glucosidase inhibition was weaker. Antibacterial activity against all four tested bacterial species was observed at 8 mg/mL but not at 4 mg/mL. Targeted LC–MS/MS quantified five phenolic constituents, with p-coumaric acid (1599.71 µg/g), chlorogenic acid (871.43 µg/g), and ferulic acid (285.50 µg/g) being the most abundant. Overall, these findings support the further investigation of silkworm feeding waste as a feedstock for thermochemical valorization into chemically and biologically evaluable bio-based fractions.
- MakaleAçık Erişim2026Scopus SJRQ3Investigation of the enzyme-inhibitory, antibacterial, and anticancer properties of metal phthalocyanines
Topal, Meryem; Topal, Fevzi; Yilmaz, Fırat; Bulut Atalay, Esra; Koçyiğit, Ümit Muhammet; Güzel, Emre
In this study, the enzyme inhibitory, antibacterial, and anticancer activities of a phthalonitrile derivative and its metal phthalocyanines (Pcs; indium, zinc, copper, cobalt, and manganese; 1–6) were investigated. The cobalt and manganese Pcs were synthesized for the first time in this study. The inhibitory activities of the symmetric Pcs, which were expected to interact with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) via their 4-(isopropylbenzyl)oxy substituents through host–guest interactions, were investigated. More selective inhibition of AChE than BChE was observed for these compounds. For AChE, CoPc was identified as the most potent inhibitor (IC50 = 14.81 nM), whereas for BChE, InPc was identified as the most potent inhibitor (IC50 = 56.35 nM). The Ki values indicated that most compounds exhibited competitive inhibition; copper phthalocyanine (CuPc) showed particularly strong inhibition against AChE (Ki = 3.08 nM ± 1.12), whereas the lowest Ki value against BChE was observed for MnPc (Ki = 25.98 ± 1.97 nM). Most compounds exhibited competitive inhibition; however, CuPc showed competitive inhibition toward AChE but a noncompetitive inhibition pattern toward BChE. Dual inhibition of AChE and BChE by these compounds may be promising for addressing cholinergic deficits associated with Alzheimer’s disease. In addition, the acceptability of compounds 1–6 with respect to pharmacological drug-likeness criteria was assessed based on predicted absorption, distribution, metabolism, excretion (ADME) outcomes. In antibacterial tests, varying levels of inhibition were observed against selected bacterial strains. In anticancer assays, all compounds exhibited high cytotoxicity against the MCF-7 breast cancer cell line. Higher antiproliferative activity was observed for CuPc than for the other compounds. Morphological changes were induced in cancer cells by CuPc and MnPc. Overall, these compounds may have potential as enzyme inhibitors and as antibacterial and anticancer agents.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2026Scopus SJRQ2In Vitro Antioxidant, Antibacterial, and Cholinesterase-Inhibitory Properties of an AqueousEuphorbia macrocladaRoot Extract Obtained by Ultrasound-Assisted Extraction
Gül, Abdulkadir; Yilmaz, Firat; Topal, Fevzi; Özgen, Inanc; Aydogmus, Ercan; Arslanoglu, Hasan
In the present study, the aqueous extract obtained from the roots of Euphorbia macroclada via ultrasound-assisted extraction (Ult-ER) was evaluated for its anticholinesterase (AChE and BChE), antioxidant, and antibacterial activities. While the extract exhibited weak inhibition against AChE (IC50: 507.69 +/- 17.95 mg/mL), it showed relatively greater inhibitory activity against BChE (IC50: 22.41 +/- 0.49 mg/mL). In antioxidant assays, Ult-ER exhibited measurable antioxidant responses, with DPPH and ABTS(+) radical-scavenging capacities of 18.33 +/- 0.49 and 119.59 +/- 1.86 mg TE/L, respectively. Its Fe-3(+) and Cu-2(+) reducing capacities were 128.51 +/- 12.57 and 670.33 +/- 11.59 mg TE/L, respectively. The total phenolic and flavonoid contents were 84.80 +/- 3.31 mg GAE/g and 60.67 +/- 2.29 mg QE/g, while the total antioxidant capacity was 9.78 +/- 0.44 mg TE/g and 15.62 +/- 1.85 mg BHAE/g. In the antibacterial evaluation, Ult-ER at the highest tested concentration of 8 mg/mL exhibited inhibitory activity against all tested strains, including Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853, whereas no detectable inhibition was observed at lower concentrations.
- MakaleAçık Erişim2025Scopus SJRQ3Cosmetological potential of the essential oil from the aerial parts of Rubus sanctus Schreb.: Enzymatic inhibition, antibacterial properties, and chemical composition
Yıldırım, Aybeniz; Celep, İnci Kurt; Gül, Abdulkadir
Recently, skin care products and cosmetic preparations with herbal ingredients have attracted considerable interest from the public. Therefore, the cosmetic industry is investigating natural products like essential oils and extracts. This study aimed to determine the anti-aging effects of the essential oil obtained from the aerial parts of Rubus sanctus Schreb. (RsEO), as well as to reveal its chemical composition and investigate its antibacterial activity. The chemical composition of RsEO was determined by using GC-MS. The anti-aging activity of RsEO was evaluated by in vitro studies of anti-collagenase, anti-elastase, anti-tyrosinase, and anti-hyaluronidase activities. The antibacterial potential of RsEO was investigated by the agar-well diffusion method against Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, and Escherichia coli. RsEO showed significant inhibition against collagenase, elastase, hyaluronidase, and tyrosinase with IC50 values of 80.46, 77.85, 72.71, and 82.71 μg/mL, respectively, and when compared with the positive controls epigallocatechin gallate (IC50: 38.91 μg/mL for collagenase, IC50: 38.91 μg/mL for elastase), tannic acid (IC50: 26.95 μg/mL for hyaluronidase), and kojic acid (IC50: 28.74 μg/mL for tyrosinase), the activities were found to be close. It was determined that the major components of RsEO were pentadecanal (8.88%), dodecanoic acid (7.86%), nonanal (4.32%), and octadecanal (4.08%). RsEO showed moderate antibacterial activity (inhibition zones between 10 and 15 mm) against the tested bacteria compared to ampicillin. This study demonstrated that RsEO is a natural product that has the potential to serve as a promising anti-aging and antibacterial therapeutic agent due to the synergistic effect of its constituent components.
AtıfScopus3WoS3OpenAlex4İncele - MakaleYayıncıda açık erişim2025Scopus SJRQ4Determination of antibacterial properties and chemical composition of pyrolysis liquid from feeding wastes of mealworm Tenebrio molitor L. (Coleoptera: Tenebrionidae) adults and larvae; [ОДРЕЂИВАЊЕ АНТИБАКТЕРИЈСКЕ АКТИВНОСТИ И ХЕМИЈСКОГ САСТАВА ПИРОЛИТИЧКЕ ТЕЧНОСТИ НАСТАЛЕ ИЗ НУТРИТИВНОГ ОТПАДА ОДРАСЛОГ ЦРВА]
Özgen, İNanç; Gül, Abdulkadi̇R; Baltaci, Cemalettin; Öner, İLyas; Aydoğmuş, Ercan
This study aimed to evaluate the antibacterial properties and phytochemical composition of pyrolysis liquids obtained from the biowaste of the mealworm Tenebrio molitor L. (Coleoptera: Tenebrionidae) adults and larvae. Biowaste was subjected to pyrolysis at 295±5 °C for 7 h under a nitrogen atmosphere using a laboratory-scale system equipped with a dual condensation unit to separate light and heavy fractions. The biowaste pyrolysis liquid (BPL) were purified and analysed for their chemical content using LC–MS/MS, which identified seven key phenolic compounds, with cinnamic acid being the most abundant (358.05 µg/g), followed by salicylic acid, 4-hydroxybenzoic acid and naringenin. Notably, the most of flavonoid derivatives were either absent or below detection limits, indicating the extract’s phenolic acid-dominated profile. The antibacterial activity of BPL was assessed against two gram-negative (E. coli ATCC-25922, P. aeruginosa ATCC-27853) and two gram-positive (E. faecalis ATCC-23212, S. aureus ATCC-25923) bacterial strains using the agar well diffusion method. The results demonstrated significant antibacterial effects, particularly against S. aureus (29.5±0.3 mm) and P. aeruginosa (23.5±0.2 mm), followed by E. coli (21.7±0.1 mm). These findings highlight the potential of insect-derived pyrolysis liquids as natural antibacterial agents, driven largely by their phenolic acid content. This study underscores the value of biowaste valorisation for developing bioactive compounds with potential applications in antimicrobial therapies.
AtıfScopus5WoS5OpenAlex6İncele - MakaleYalnız künye2022Scopus SJRQ2In vitro and in silico evaluation of some plant extracts and phytocompounds against multidrug-resistant Gram-negative bacteria
Aydemir, Eda; Sarıyer, Emrah; Akyıldız, Esma; Özad Düzgün, Azer; Camadan, Yasemin; Saral Sarıyer, Ayşegül
The spread of multidrug-resistant Gram-negative (MDR) bacteria is a global public health problem, as infections caused by MDR Gram-negative bacteria are difficult to treat. New antibiotic agents need to be developed to overcome this problem, and phytochemicals show promise at this point. In this study, methanol extracts were prepared from cinnamon, thyme, nettle, white tea, rosehip, and antibacterial activity of the methanol extracts was studied against two MDR Gram-Negative bacteria (K. pneumoniae and A. baumannii) by broth microdilution method. The MICs of methanol extracts of cinnamon, rosehip, thyme, white tea for A. baumannii were found as 0.015125 g/ml, 0.07825 g/ml, 0.030625 g/ml, 0.00796875 g/ml, respectively. It was found that only cinnamon methanol extract had antibacterial activity in the used extract concentrations against K. pneumoniae and the MIC value was 0.0605 g/ml. The effects of plant methanol extract with antibacterial activity and imipenem combinations were studied in vitro using the checkerboard method. The FIC Indexes were obtained from the checkerboard results and it was observed that the combination of methanol extract and imipenem showed an antagonistic or additive/indifferent effect but not a synergistic effect. We evaluated the binding affinity of epigallocatechin 3-gallate, quercetin, cinnamaldehyde, carvacrol, and thymol phytocompounds using in silico methods, which are well known as a phytocompounds in white tea, cinnamon, thyme, nettle, and rosehip and have antibacterial activities. The results suggested that these phytocompounds should be supported with in vivo and in vitro experiments to investigate their potential for being inhibitor candidates.
AtıfScopus6WoS4OpenAlex6İncele