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Investigation of class 1 integrons with antibiotic resistance genes in multidrug-resistant acinetobacter baumannii strains and determination of plant extract effects on multidrug-resistant isolates

MakaleAçık ErişimScopus SJRQ2
  • SDG 3 · Sağlık ve Kaliteli Yaşam

Özet

This study aimed to investigate the presence of resistance genes in multidrug-resistant A. baumannii isolates as well as to determine the antibacterial activity of selected plant extracts against isolates. 41 strains were isolated from various clinical samples. PCR tests were performed using the primers. Methanol was used as solvent for the preparation of the plant extracts. MIC values of the plant extracts were determined by the broth microdilution method. The blaOXA-23, blaCTX-M-1, blaCTX-M-2, blaGES genes and Class 1 integrons were detected in five isolated strains. The lowest MIC value (2.25 mg/mL) was determined for the Echinacea purpurea extract, while the highest MIC value (50 mg/mL) was determined for the Morus alba extract. Determination of the antibacterial effect of plants extracts used in the study against A. baumannii isolates shows the importance of screening the antibacterial activity of plants in the fight against antibiotic resistance.

Anahtar Kelimeler

MICPlant extractResistance
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/gumushane/14576Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.31925/farmacia.2021.5.13Yayıncı resmi DOI adresi
İndeks kayıtları
ScopusScopusWeb of ScienceWeb of Science
Kaydın indeks veri tabanlarındaki sayfası (aktarımda alınan kayıt numarasıyla). Erişim, indeksin kendi koşullarına bağlıdır.
Atıflar
Scopus
1
WoS
1
OpenAlex
3
Her kaynağın kendi saydığı toplam atıf; aktarım ve zenginleştirme sırasında alındı.
Tam Kayıt
AlanDeğerDil
dc.contributor.authorSaral, Ayşegül
dc.contributor.authorCinemre, Sedanur
dc.contributor.authorOkumuş, Funda
dc.contributor.authorAkar, Zeynep
dc.contributor.authorÇiçek, Ayşegül Çopur
dc.contributor.authorDüzgün, Azer Özad
dc.date.accessioned2026-10-22T10:22:52.787911589Z
dc.date.available2026-10-22T10:22:52.787911589Z
dc.date.issued2021
dc.description.abstractThis study aimed to investigate the presence of resistance genes in multidrug-resistant A. baumannii isolates as well as to determine the antibacterial activity of selected plant extracts against isolates. 41 strains were isolated from various clinical samples. PCR tests were performed using the primers. Methanol was used as solvent for the preparation of the plant extracts. MIC values of the plant extracts were determined by the broth microdilution method. The blaOXA-23, blaCTX-M-1, blaCTX-M-2, blaGES genes and Class 1 integrons were detected in five isolated strains. The lowest MIC value (2.25 mg/mL) was determined for the Echinacea purpurea extract, while the highest MIC value (50 mg/mL) was determined for the Morus alba extract. Determination of the antibacterial effect of plants extracts used in the study against A. baumannii isolates shows the importance of screening the antibacterial activity of plants in the fight against antibiotic resistance.
dc.identifier.doi10.31925/farmacia.2021.5.13
dc.identifier.eissn2065-0019
dc.identifier.endpage918
dc.identifier.issn0014-8237
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85120820539
dc.identifier.startpage914
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/gumushane/14576
dc.identifier.volume69
dc.identifier.wosWOS:000713322700013
dc.language.isoen
dc.publisherRomanian Society for Pharmaceutical Sciences
dc.relation.ispartofFarmacia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMIC
dc.subjectPlant extract
dc.subjectResistance
dc.subject.classificationPharmacology & Pharmacy
dc.subject.otherAquilaria agallocha extract
dc.subject.othercefotaxime
dc.subject.otherceftazidime
dc.subject.othercolistin
dc.subject.otherEchinacea purpurea extract
dc.subject.otherextended spectrum beta lactamase
dc.subject.othergentamicin
dc.subject.otherginger extract
dc.subject.otherHypericum perforatum extract
dc.subject.otherimipenem
dc.subject.otherlevofloxacin
dc.subject.otherLycium barbarum extract
dc.subject.othermulberry extract
dc.subject.othernetilmicin
dc.subject.otherNigella sativa extract
dc.subject.otherpiperacillin
dc.subject.otherpiperacillin plus tazobactam
dc.subject.otherplant extract
dc.subject.otherrosa canina extract
dc.subject.othertobramycin
dc.subject.otherunclassified drug
dc.subject.otheramino acid sequence
dc.subject.otherantibacterial activity
dc.subject.otherantibiotic resistance
dc.subject.otherantimicrobial activity
dc.subject.otherArticle
dc.subject.otherbacterial gene
dc.subject.otherbacterial strain
dc.subject.otherbacterium isolate
dc.subject.otherclass 1 integron
dc.subject.otherdisk diffusion
dc.subject.otherDNA isolation
dc.subject.otherminimum inhibitory concentration
dc.subject.othermultidrug resistant Acinetobacter baumannii
dc.subject.othernonhuman
dc.subject.otherpolymerase chain reaction
dc.subject.otherPseudomonas aeruginosa
dc.titleInvestigation of class 1 integrons with antibiotic resistance genes in multidrug-resistant acinetobacter baumannii strains and determination of plant extract effects on multidrug-resistant isolates
dc.typeArticle
rdl.citation.openalex3
rdl.citation.scopus1
rdl.citation.wos1
rdl.oa.statusgold
rdl.oa.urlhttps://farmaciajournal.com/wp-content/uploads/art-13-Saral_Ozad-Duzgun_914-918.pdf
rdl.scopus.quartileQ2
rdl.sdgSDG03
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)