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Koleksiyondaki öğeler
- MakaleYalnız künye2025Scopus SJRQ2Design of a fractional-order neural network-based fixed-time sliding mode controller for chaotic satellite attitude control and synchronization
Bingöl, Ozhan
PurposeThis study aims to propose a novel fractional-order neural network-based fixed-time sliding mode controller to address the challenges of chaotic satellite attitude control, synchronization and anti-synchronization. By integrating fractional-order dynamics and neural network-based estimation, the proposed approach enhances robustness and adaptability in stabilizing complex systems.Design/methodology/approachThe proposed control scheme introduces a novel sliding surface that leverages fractional calculus to improve convergence speed and control flexibility. A neural network is used to adaptively estimate unknown error dynamics, compensating for uncertainties in the system. The fixed-time stability property guarantees convergence within a predefined time, independent of initial conditions. Theoretical stability proofs and numerical simulations are conducted to validate the effectiveness of the proposed controller.FindingsThe results demonstrate that the proposed controller effectively stabilizes chaotic satellite attitude dynamics and ensures reliable synchronization and anti-synchronization. The approach exhibits strong robustness against system uncertainties and external disturbances while achieving fixed-time convergence.Originality/valueThis work advances the field by integrating fractional-order dynamics with a neural network-based adaptive mechanism in a fixed-time sliding mode control framework. The proposed method enhances convergence properties and robustness in controlling chaotic satellite attitude systems, providing a novel and effective solution for complex nonlinear dynamics.
AtıfWoS4OpenAlex3
İncele - MakaleYalnız künye2026Examining the relationship between ethical values and self-discipline
Gül, Ismail; Koç, Ozcan; Arslan, Adem
Healthcare management students undergo an educational process aimed at acquiring various knowledge and skills to achieve professional competence. Self-discipline and ethical values play a crucial role in both academic success and professional development during this process. Self-discipline contributes to students' timely and effective completion of their duties, while ethical values enhance individuals' ability to distin-guish right from wrong and to act in accordance with social norms. This study examined the relationship between the ethical value perceptions and self-discipline levels of G & uuml;m & uuml;shane University Health Management students. Quantitative methods were used in the study and data were collected via a survey. The data obtained were analyzed using t-tests, ANOVA, and correlation analysis. The analysis results revealed a significant relationship between students' ethical value perceptions and self-discipline levels. These findings demonstrate that ethical values and self-discipline are not inde-pendent concepts; rather, they are interconnected, complementary, and reinforcing. The research is expected to contribute to the development of educational programs in the field of healthcare management and to guide practices aimed at increasing students' ethical and self-discipline levels.
- MakaleYalnız künye2015Scopus SJRQ3EVALUATION OF ENERGY ABSORPTION OF MACRO SYNTHETIC AND STEEL FIBER REINFORCED CONCRETES
Bolat, Hakan; Simsek, Osman
This study alms to determine the energy absorption of concrete slabs (60x60x10cm) using polyester, polypropylene and steel fiber reinforced (SFRC, PYFRC, PPFRC) according to EN 14488-5. Significant differences in the energy absorption were observed between the concrete slabs strengthened with different fibers. The highest gain In energy absorption was observed In SFRC. Furthermore, concrete slabs strengthened with PPFRC and PYFRC showed 23.4% and 14.8% less energy to SFRC. Although the SFRC showed the highest energy absorption under directly negative conditions, it is important to evaluate the durability issues associated with SFRC, such negative conditions.
AtıfWoS7İncele - MakaleAçık Erişim2021The Effect of Religiosity on Hedonic Consumption and Wasteful Consumption Behavior
Avci, Ibrahim; Hacikelesoglu, Hizir
The present study aims to determine whether religiosity affects hedonic consumption behavior, which expresses pleasure-oriented consumption behavior, and wasteful consumption behavior, which expresses waste-oriented consumption behavior, and whether hedonic consumption behavior has an effect on wasteful consumption behavior. For this purpose, the convenience sampling method was chosen among the sampling methods, and the data was collected with the online questionnaire form. During the data collection process, 490 participants were reached, but as a result of the removal of incorrect questionnaires, the data of 481 participants were included in the analysis. In the analysis of the obtained data, frequency analysis, factor analysis, and Structural Equation Model analysis were performed by using SPSS 21 and AMOS 24 programs. As a result of the study, it was determined that religiosity has a negative effect on hedonic consumption behavior and wasteful consumption behavior, while hedonic consumption behavior has a positive effect on wasteful consumption.
AtıfWoS1OpenAlex6TR Dizin6
İncele - MakaleYalnız künye2020The Effects of Explosive Strength Applied to Footballers on Some Physical and Physiological Parameters
Zambak, Omer; Sever, M. Onur
It is aimed to investigate the effects of explosive strength training on aerobic capacity, anaerobic capacity, blood pressure, resting heart rate and shooting speed. The aim of this study was to investigate the explosive strength training on some physical and physiological parameters. The study included 38 volunteer 1st and 2nd amateur league footballers aged 1825 years. Aerobic capacities of the players were measured by shuttle run test and Anaerobic power measurement by vertical jump test. After calculating the vertical jump value of the athletes anaerobic strength; calculated using the Lewis Nomogram using vertical jump and body weight values. The shooting speed of the players was determined by speed pocket radar equipment In the study, different strength training (station training method) and football-specific technical and tactical training programs were applied to the research group for 8 weeks, 3 days a week. only technical and tactical training programs were applied to the control group. The parameters were taken twice before and after the 8-week study. In order to determine the differences between the pre-test and post-test results, The Wilcoxon test, one of the nonparametric tests, was used to, Mann Whitney U-test analysis was used to compare the pre-test and post-test values between the groups. The significance level of the study was accepted as p<0.05. Significant difference in shooting speed was found as a result of the signed ranks test comparing the pre-test and post-test measurements of the research group participants (p<0,05). Significant differences between the measurements of aerobic power, anaerobic power were found as a result of the signed ranks test comparing the pre-test and post-test values of the control group participants (p<0,05). After the Mann-Whitney U test, where the posttest measurement values of the experimental and control group participants were compared, there was a significant difference between the groups in aerobic power values, and this difference was found to be in favor of the experimental group participants (p <0.05). As a result, it can be said that explosive strength training applied to amateur football players between the ages of 18 - 25 increases the shooting speed.
AtıfWoS1İncele - BildiriAçık Erişim2021Automatic Sleep Scoring System Based On Autoregressive Model
Melek, Mesut
Electroencephalography (EEG) signals recorded during sleep are divided into 30-second segments and analyzed by experts and classified into sleep stages, and in this way, diagnosis and treatment of diseases are made. Computer-assisted sleep scoring systems can effectively reduce the burden of experts by classifying sleep stages. In this study, after preprocessing of the EEG signals, four features were obtained for each EEG band (20 features in total) with the autoregressive model and then classified with three different classifiers common in machine learning. The proposed method was tested on the data set called ISRUC sleep (Subgroup 3, ISRUC3) and the results were compared with the results of other studies. The results show that the proposed method is more successful than other existing methods, despite the use of fewer features.
AtıfOpenAlex1İncele - MakaleAçık Erişim2022The Effect Of Conspicuous Consumption Behavior On Wasteful Consumption Behavior: The Intermediary Role Of Hedonic Consumption Behavior
Avci, Ibrahim
The concept of consumption, which has an important place in people's lives, is generally expressed as the use of produced goods and services in line with needs. Consumption now includes the psychological needs of people as well as their physical needs. Consumers can buy things they do not need by acting pleasure-orientedly, and they exhibit consumption behaviors to provide psychological satisfaction. One of the consumer-purchase patterns is found to demonstrate others in the social environment. Therefore, non-need consumption focused on pleasure and display causes excessive consumption; this situation can also cause wastefulness. Accordingly, in the present study, the aim was to examine the effect ofconspicuous consumption behavior on wasteful consumption behavior and the mediating role of hedonic consumption behavior in this effect. With the online survey form prepared, 519 participants were reached between the dates of 21.05.2020-06.07.2020. The data obtained were analyzed with the SPSS 21, AMOS 24, and PROCESS 3.5 programs. After the analysis, it was concluded that conspicuous consumption behavior has an effect on wasteful consumption behavior and that hedonic consumption behavior has a mediating effect.
AtıfWoS5OpenAlex7TR Dizin3İncele - MakaleYalnız künye2022Scopus SJRQ1How human capital affects labor income share at the sectoral level?: Evidence from the EU-13 countries and the UK
Çelik, Orkun
Purpose The author investigates the effects of human capital on labor income share in the 15 sectors of the European Union (EU)-13 countries and the United Kingdom (UK) over the period 2008-2015. Design/methodology/approach The author employs pooled ordinary least squares (OLS) estimation with panel data, using the EU KLEMS database. Findings The results show that when education level increases, labor income share increases and gender-based labor income share differentials decrease. Return to education is higher in qualitative sectors in contrast with the other sectors. Moreover, there are gender-based labor income share differentials at the sectoral level. These differentials are higher in nonqualitative sectors, while they are relatively lower in qualitative sectors. Research limitations/implications The biggest limitation of the study is that the data range cannot be expanded because of the database. The author is of opinion that the empirical findings will guide to policy makers in terms of wage setting. Originality/value The expected contribution of this study to the literature is to investigate the effect of human capital on labor income share at the sectoral level for the EU-13 countries and the UK. As far as the author knows, there is no study which investigates this topic at the sectoral level such a comprehensive, in the literature.
AtıfWoS5OpenAlex6İncele - BildiriYalnız künye2023Deep Learning Based Focus Measurement Operator for 3D Imaging in Microscopic Systems
Dogan, Hulya; Dogan, Ramazan Ozgur
Since 3D imaging in microscopic systems makes cell and tissue structures more prominent and visible, it provides higher performance in image processing applications such as automatic segmentation, recognition, classification, alignment and stitching. For this reason, 3D imaging in microscopic systems has been one of the most comprehensive and long-studied research areas in the literature. It seems that the most frequently preferred strategy for 3D imaging is shape from focus. Shape from focus is a strategy that uses a sequence of 2D images with the same perspective and different focused regions to create the 3D shape of the sample. Focus measurement operators are applied to extract the focus properties of the input images in shape from focus strategies. These operators have several limitations, such as more precise characterization of curves and edges in images. Researchers often use a pre- or post-processing technique to minimize these limitations, rather than proposing a new focus measurement operator. In this study, a deep learning based focus measurement operator, which does not require a pre- or post-processing technique, is developed to eliminate these limitations. The qualitative and quantitative results obtained in the study show that the proposed focus measurement operator is more effective in 3D imaging than other operators in the literature.
- MakaleYalnız künye2025An evaluation on the transformation of local governments in Turkey with new public management reforms
Dogan, Kadir Caner
As globalization increased its importance in the world after the 1980s, local governments emerged as an active administrative subject in this process. As a matter of fact, local governments increased their capacity in terms of democracy and efficiency by integrating with the new public administration reforms that increased their impact in this period. As a matter of fact, a similar process took place in Turkey. In this study, it is aimed to focus on democracy, participation and effectiveness at the principle and institutional level after the regulation of local governments in Turkey with new public management reforms. The method of the study is literature review within the framework of qualitative analysis.
- MakaleYalnız künye2026Scopus SJRQ4Determining Grain Quality (Physical and Chemical) Properties and Nutritional Values in Some Two-Rowed Barley (Hordeum vulgare conv. distichon) Cultivars Grown in Terrestrial Climate Conditions
Sirat, Abdulveli
Barley grain is rich in nutritional value and mineral elements. It is an important cereal crop used human food, malt and feed for animals. This study was conducted to determine some physical and chemical quality characteristics, like thousand-grain and hectoliter weight, protein, moisture, ash, starch, oil, ADF (acid detergent fiber), NDF (neutral detergent fiber) percent, potassium (K), magnesium (Mg), and phosphorus (P) contents of 14 two-rowed barley cultivars (Akar, Burakbey, Tarm-92, Aydanhan & imath;m, Zeynelaga, Keser, Balkan-96, Hilal, Sur 93,Sahin 91, Cumra-2001, Erciyes, Efes-98, Anadolu 98) with a randomized complete block design and three replications for two years during the 2016-2018 growing seasons (wintery) in the terrestrial climate conditions ofSiran-Gumu & scedil;hane (Turkiye) located in the Eastern Black Sea Region. According to the two-year mean results, the thousand-grain weight of the cultivars ranged between 35.74-46.27 g, hectoliter weight 62.03-68.18 kg hl(-1,) protein percent 10.20-14.08%, moisture percent 09.32-09.75%, ash percent 1.99-2.21%, starch percent 57.22-61.77%, oil percent 1.52-2.02%, ADF percent 5.72-7.82%, NDF percent 21.19-23.20%, K content 0.657-0.742%, Mg content 0.156-0.191% and P content 0.401-0.430%. A positive and significant correlation was determined between thousand-grain weight and hectoliter weight, starch, oil, ADF, NDF, K, Mg, and P percent. Aydanhan & imath;m, Cumra-2001, Akar, Efes-98 and Balkan-96 cultivars were the prominent cultivars in terms of Physical and chemical quality characteristics and mineral substance values were evaluated in the study. Therefore, it is seen that these cultivars can be recommended to farmers who grow forage barley in the region.
- MakaleAçık Erişim2025Scopus SJRQ2Management of Major Arterial Injuries: A Critical Complication of Endoscopic Endonasal Surgery
Emengen, Atakan; Yilmaz, Eren; Gokbel, Aykut; Uzuner, Ayse; Cakir, Ozgur; Ciftci, Ercument; Ozsoy, Bedrettin; Ergen, Anil; Caklili, Melih; Cabuk, Burak
BACKGROUND AND OBJECTIVES:Endoscopic endonasal surgery (EES) is the preferred approach for treating sellar and parasellar lesions due to its panoramic view and detailed anatomical definition. This study aims to review major arterial injuries during EES, a rare but critical complication associated with high mortality and morbidity rates.METHODS:A retrospective analysis was conducted, including 15 patients from 5640 EES procedures performed between August 1997 and February 2024 at in our center/Department of Neurosurgery. The study focuses on perioperative and postoperative management strategies, highlighting the use of oxidized regenerated cellulose (Surgicel (R))/gelatin-thrombin matrix (Floseal (R)) and multidisciplinary collaboration to achieve hemostasis.RESULTS:The incidence of major arterial injury was 0.2%, with a mean patient age of 38.4 years and a female-to-male ratio of 10:5. The most common tumors were adenomas (n = 7) and chordomas (n = 5). The most commonly bleeding arteries in 6 patients each are the cavernous segment of the internal carotid artery and the paraclival carotid artery. Low-flow bleeding was observed in 10 of our patients, while high-flow bleeding was seen in 5 patients, 4 of whom were recurrent cases (P < .05). In 3 patients with high-flow bleeding from segments of the carotid artery, digital subtraction angiography was performed for stent placement or coil embolization, while in 1 patient with high-flow bleeding, digital subtraction angiography was used for monitoring cerebral blood flow. One of our patients died of a myocardial infarction at the 14th month of follow-up and 1 of our patients developed left-hemiparesis.CONCLUSION:The study underscores the importance of preoperative planning, surgical expertise, and multidisciplinary teamwork in managing major arterial injuries during EES. The authors advocate for the development of standardized treatment algorithms to improve outcomes in these patients. The findings contribute to the limited literature on managing internal carotid artery injuries in EES, emphasizing the need for ongoing research and algorithm development.
AtıfWoS2OpenAlex4
İncele - MakaleYalnız künye2015Scopus SJRQ1Neuroanatomical correlates of genetic risk for bipolar disorder: A voxel-based morphometry study in bipolar type I patients and healthy first degree relatives
Sariçiçek, Aybala; Yalin, Nefize; Hidiroglu, Ceren; Çavusoglu, Berrin; Tas, Cumhur; Ceylan, Deniz; Zorlu, Nabi; Ada, Emel; Tunca, Zeliha; Özerdem, Aysegul
Background: Bipolar disorder (BD) is a highly heritable mental illness which is associated with neuroanatomical abnormalities. Investigating healthy individuals at high genetic risk for bipolar disorder may help to identify neuroanatomical markers of risk and resilience without the confounding effects of burden of illness or medication. Methods: Structural magnetic resonance imaging scans were acquired from 30 euthymic patients with BD-1 (BP), 28 healthy first degree relatives of BD-I patients (HR), and 30 healthy controls (HC). Data was analyzed using DARTEL for voxel based morphometry in SPM8. Results: Whole-brain analysis revealed a significant main effect of group in the gray matter volume in bilateral inferior frontal gyrus, left parahippocampal gyrus, left lingual gyrus and cerebellum, posterior cingulate gyrus, and supramarginal gyrus (alphasim corrected (<= 0.05 FWE)). Post-hoc t-tests showed that inferior frontal gyrus volumes were bilaterally larger both in BP and HR than in HC. BP and HR also had smaller cerebellar volume compared with HC. In addition, BP had smaller left lingual gyms volume, whereas HR had larger left parahippocampal and supramarginal gyms volume compared with HC. Limitations: This study was cross-sectional and the sample size was not large. All bipolar patients were on medication, therefore we were not able to exclude medication effects in bipolar group in this study. Conclusions: Our findings suggest that increased inferior frontal gyms and decreased cerebellar volumes might be associated with genetic predisposition for bipolar disorder. Longitudinal studies are needed to better understand the predictive and prognostic value of structural changes in these regions. (C) 2015 Elsevier B.V. All rights reserved.
AtıfWoS49OpenAlex58İncele - MakaleYalnız künye2020Scopus SJRQ4Hepatic venous Doppler assessment can anticipate simplified pulmonary embolism severity index and right ventricle dysfunction in patients with acute pulmonary embolism
Acar, Emrah; Izci, Servet; Inanir, Mehmet; Yilmaz, Mehmet F.; Izgi, Ibrahim A.; Gokce, Mustafa; Kirma, Cevat
Purpose Acute pulmonary embolism (APE) is a life-threating cardiothoracic thromboembolic emergency in which right ventricle dysfunction (RVD) is a major concern. In the present study, we examined the hepatic veins (HVs) blood flow with pulsed-wave spectral Doppler ultrasonography to determine its relationship with the simplified pulmonary embolism severity index (sPESI) and the patient's RVD status. Methods We divided the 243 patients who met the inclusion criteria into two groups based on both their sPESI scores and their RVD status. Transthoracic echocardiography was performed to evaluate the RVD and the HVs within 1 hour after patient admission. The liver was evaluated using subcostal and intercostal echocardiographic windows in grayscale B-mode, and HVs were assessed using color and spectral Doppler assessment though the same echocardiographic windows. Result A cut-off value of the systolic reverse flow velocity-time integral (SrVTI) = 2.2 cm carried a sensitivity and specificity of 84.29% and 74.89%, respectively, for the prediction of sPESI >= 1. A SrVTI cut-off value of 2.1 cm yielded a sensitivity and specificity of 83.03% and 73.91%, respectively, for the prediction of RVD. Conclusion HV Doppler assessment could be a useful method for anticipating the sPESI and the presence of RVD in patients with APE. In addition, it may provide information regarding the hemodynamic impact of APE.
AtıfWoS3OpenAlex3İncele - MakaleYalnız künye2021Scopus SJRQ3Time interval between E and E′ waves can predict complicated clinical course in patients with acute pulmonary embolism
Acar, Emrah; Kilicgedik, Alev; Izci, Servet; Inanir, Mehmet; Yilmaz, Mehmet Fatih; Gokce, Mustafa; Izgi, Ibrahim Akin; Kirma, Cevat
Purpose Acute pulmonary embolism is a life-threatening cardiothoracic emergency leading to right ventricle systolic and diastolic dysfunction. In the present study, we investigated the right ventricle diastolic function and its predictive value in patients with acute pulmonary embolism. Material and methods Were prospectively recruited in this study 621 patients diagnosed with acute pulmonary embolism between December 2015 and June 2019. Among them, 173 were excluded, leaving 448 patients for follow-up. Transthoracic echocardiography was performed for the evaluation of the right ventricle systolic and diastolic indices. At 30-day follow-up, the patients were allocated either into the benign or in the complicated clinical course group. Results The group with complicated clinical course had higher value of pulmonary artery systolic pressure (PASP), right/left ventricle diameter ratio, E-wave velocity, E/A ratio, A ' wave velocity, E/E ' ratio, and time interval between E and E ' waves (P < .05), but lower values of tricuspid annular plane systolic excursion, A-wave velocity, isovolumetric relaxation time, deceleration time, E ', and E '/A ' (P < .05). Complicated clinical course was associated with shorter isovolumetric relaxation time (r = .564, P < .001), E/E ' (r = .495, P < .001), and TE-E ' (r = .596, P < .001). Receiver operator characteristic curve analysis showed that TE-E ' had the largest area under curve (TE-E ' 0.82, IVRT 0.77, E/E ' 0.72). A cut-off value of TE-E ' = 70 milliseconds had an 81.1% sensitivity and 71.4% specificity for the prediction of the complicated clinical course. Conclusion The assessment of the right ventricle diastolic function could predict the complicated clinical course in patients with acute pulmonary embolism.
AtıfWoS3OpenAlex3İncele - BildiriYalnız künye2016Scopus SJRQ1The effects of gallic acid on the acute necrotizing pancreatitis in rats
Kural, B.; Altay, D. Us; Kahraman, C.; Alhan, E.; Sen, T. Mazlum; Ercin, C.; Kent, N. Kucuk; Kara, H.; Kör, S.; Örem, A.
- MakaleAçık Erişim2026Scopus SJRQ1The mediating role of physical self-perception and the moderating effect of gender in the association between physical activity and psychological well-being among young recreational participants
Ekizoglu, Ozlem; Tetik, Sibel; Zambak, Omer; Temur, Canan Sayin; Can, Yusuf; Isik, Utku; Koc, Mustafa Can
Background/objective Psychological well-being disorders are increasingly prevalent among young people. While physical activity is known to benefit psychological well-being, the mechanisms-particularly the role of physical self-perception and gender in recreational context remain underexplored. Grounded in the Conservation of Resources (COR) Theory, this study investigates the mediating role of physical self-perception in the relationship between recreational physical activity and psychological well-being and examines whether gender moderates this mediation among youth aged 15-24.Methods A descriptive-relational survey design was employed. The sample comprised 468 young adults (58.5% male, 41.5% female; M_age = 20.08) who regularly participated in recreational physical activities. Data were collected using the International Physical Activity Questionnaire-Short Form (IPAQ-SF), the Physical Self-Perception Profile (PSPP), and the Warwick-Edinburgh Mental Well-being Scale (WEMWBS). Mediation and moderation analyses were conducted using PROCESS macro-Models 4 and 7.Results The direct effect of physical activity on psychological well-being was not significant. However, physical self-perception fully mediated the relationship between physical activity and psychological well-being (indirect effect: beta = 0.219, 95% CI [0.151, 0.290]). Among the sub-dimensions of physical self-perception, body attractiveness had the strongest mediating effect. Moderation analysis revealed that gender did not significantly moderate the mediation pathways (a path: p = 0.156; b path: p = 0.954). The mediation mechanism operated with similar strength in both males and females.Conclusion Recreational physical activity improves psychological well-being entirely through the enhancement of physical self-perception, supporting the COR theory that physical activity acts as a resource investment. This mechanism is universal across genders in recreational settings. Interventions aiming to improve youth psychological well-being should not only promote physical activity but specifically focus on fostering positive physical self-perception and body image in inclusive, non-judgmental environments.
- BildiriYalnız künye2007Scopus SJRQ1Which of the criteria is more accurate ADA(IFG100) or IDF(IFG110) for the prediction of IGT 1 and IGT2 at high risk group? The RISK Study Results III
Yilmaz, T.; Sargin, M.; Olmez, B.; Karadeniz, S.; Oguzhan, B.
- MakaleAçık Erişim2020Scopus SJRQ4Investigation of Fosfomycin and Chloramphenicol Susceptibility of Carbapenemase-Producing Klebsiella pneumoniae Strains
Borsa, Baris Ata; Güngördü-Dalar, Zeynep; Karakullukçu, Asiye; Özalp, Veli Cengiz; Aygün, Gokhan
Objective: Antimicrobial resistance is one of the most mportant health problems of recent years. Multidrug-resistant Klebsiella pneumoniae strains have been causing serious problems in many countries including Turkey in recent years. Aim of this study was to detect molecular mechanisms behind the carbapenem resistance in carbapenem-resistant K. pneurnoniae strains isolated from rectal swab samples and investigate the susceptibility of two potentially alternative drugs, fosfornycin, and chloramphenicol. Methods: 46 K. pneumoniae strains isolated from rectal screening cultures of intensive care unit patients by using MacConkey agar containing 2 mg/L meropenem were included in this study. Carbapenem resistance of strains were confirmed by minimum inhibitor concentrations of meropenem obtained with gradient strip test. Presence of the bla(KPC,) bla(NDM) and bla(OXA), bla(IMP) and bla(VIM) genes were investigated by the real-time polymerase chain reaction. Broth microdilution method was used to investigate chloramphenicol susceptibility, and gradient strip test was used to investigate fosfomycin susceptibility of the strains. Results: At least one carbapenemase gene was detected in all K. pneumoniae strains. While all strains were found positive for the presence of OXA-48 type carbapenemase gene, 12 (26%) out of 46 were positive for both OXA-48 and NDM-1 carbapenemase genes, and only one (2%) strain was positive for OXA-48, NDM-1, and IMP-1 carbapenemase genes. Only 3 (6%) out of 46 strains were found susceptible to fosfomycin while 23 (50%) of them were susceptible to chloramphenicol. Additionally, we observed that the resistance rates to fosfomycin and chloamphenicol tended to be higher among carbapenemase producers. Conclusions: It is estimated that fosfomycin is not going to be a good option for the treatment of infections caused by carbapenemresistant K. pneumoniae strains in Turkey since only 6% of them were susceptible. Although the chloramphenicol susceptibility rate (50%) was higher than fosfomycin, further clinical studies are required to provide a better knowledge about the usage of this antibiotic in systemic infections. Moreover, multiple carbapenemase producers tended to be more resistant to fosfomycin and also chloramphenicol.
- MakaleAçık Erişim2023Neuropsychological and clinical correlations of optical coherence tomography findings in patients with schizophrenia
Kani, Ayse Sakalli; Çam, Cansun Sahin; Çelik, Esra Biberoglu; Dural, Uzay; Dönmez, Melike Duran; Turhan, Semra Akkaya; Toker, Ayse Ebru; Yildiz, Mesut
Objective: There are increasing studies examining retinal fiber layer (RNFL) and ganglion cell layer (GCL) thinning in patients with schizophrenia. However, the results are controversial, and clinical and cognitive reflections of these findings remain unclear. With this study, we aim to examine retinal abnormalities and establish correlations with cognitive and clinical parameters.Methods: In this cross-sectional study, we examined 29 patients with schizophrenia and 13 age and gender-matched healthy controls. All participants underwent psychometric assessment, neuropsychological tests, and optical coherence tomography (OCT) measurements. The retinal fiber layer and ganglion cell layer thickness were used as retinal parameters.Results: Five patients dropped out during the OCT measurement process, 24 patients with schizophrenia and nine healthy controls were included in the analysis. There was no statistically significant difference between groups in measuring retinal nerve fiber layer or ganglion cell layer thicknesses. The verbal fluency test score negatively correlated with left RNFL superior (p = - .422, p <.05). STROOP response duration positively correlated with right RNFL on average (p = .551, p <.05), left RNFL on average (p = .498, p <.05), right RNFL superior (p = .507, p <.05), left RNFL superior (p = .461, p <.05) and right RNFL temporal values (p = .434, p <.05). STROOP response error was also positively correlated with right RNFL temporal thickness (p = .430, p <.05). STROOP response duration was positively correlated with right GCL total (p = .646, p <.01), right GCL superior (p = .658, p <.01) and right GCL inferior (p = .596, p <.01) thickness.Conclusion: We did not find a significant relationship between reduced RNFL or GCL thickness and cognitive impairment. However, we had several positive correlations between cognitive task scores and RNFL and GCL thicknesses. Additionally, our study did not correlate symptom severity and clinical severity parameters with reduced RNFL or GCL thickness.
AtıfWoS1OpenAlex2İncele
