Sürdürülebilir Kalkınma Amaçları

• 2

Yazarlar

• Alver, Ahmet(2)
• Demir, Selim(2)
• Turan, Ibrahim(2)
• Alver, A.(1)
• Capkin A, Aydin(1)
• Demir, S.(1)
• Fidan, Evren(1)
• Fidan, Sami(1)
• Güven, Süleyman(1)
• Karahan, Süleyman Caner(1)
• Karkucak, M.(1)
• Kavgaci, Halil(1)
• Mentese, A.(1)
• Mentese, Ahmet(1)
• Menteşe, Ahmet(1)
• Sumer, A.(1)
• Sumer, Aysegul(1)
• Sümer, Ayşegül(1)
• Turan, I(1)
• Us, Altay D.(1)
• Yaman S, Ozer(1)
• Yaman, Serap Ozer(1)

• MakaleAçık Erişim2017Scopus SJRQ3/r/gumushane/12986
  Detection of autoantibodies against carbonic anhydrase I and II in the plasma of patients with gastric cancer

  Mentese, Ahmet; Fidan, Evren; Alver, Ahmet; Demir, Selim; Yaman, Serap Ozer; Sumer, Aysegul; Fidan, Sami; Kavgaci, Halil; Turan, Ibrahim

  Cancer is the second leading cause of death and gastric cancer is the fourth most common cancer type worldwide. Investigation of autoantibodies in cancer patients has been a popular research area in recent years. The aim of the current study was to investigate carbonic anhydrase I and II (CA I and II) autoantibodies in the plasma of subjects with gastric cancer based on the information and considerations of autoimmune relation of gastric cancer. Anti-CA I and II antibody levels were investigated by ELISA in plasma samples of fifty two patients with gastric cancer and thirty five healthy peers. Anti-CA I and II antibody titers of the gastric cancer group were significantly higher compared with the control group (p = 0.004, p = 0.0001, respectively). Plasma anti-CA I levels of the metastatic group were lower than the non-metastatic group and this difference was found statistically significant (p < 0.05), but there was no statistical difference between plasma anti-CA II levels of the groups. CA I and II autoantibody titers in patients with gastric cancer were found higher compared to healthy subjects and the results suggest that these autoantibodies may be involved in the pathogenesis of gastric cancer.

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  AtıfScopus8·WoS7·OpenAlex7

  İncele
• MakaleYalnız künye2017Scopus SJRQ3/r/gumushane/10428
  Carbonic anhydrase I and II autoantibodies in Behcet's disease

  Mentese, A.; Alver, A.; Demir, S.; Sumer, A.; Yaman S, Ozer; Karkucak, M.; Capkin A, Aydin; Us, Altay D.; Turan, I

  Background: Behcet's disease ( BD) is a vasculitis, seen more frequently around the Mediterranean and the Far East, and evinces with oral and genital ulcerations, skin lesions and uveitis. Carbonic anhydrase ( CA) is a metalloenzyme which is widely distributed in the living world, and it is essential for the regulation of acid-base balance. Anti-CA antibodies have been reported in many disorders, such as systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, endometriosis, idiopathic chronic pancreatitis, type 1 diabetes and Graves' disease. The goal of this study was to investigate CA I and II autoantibodies in BD. Methods: 35 patients with BD and 29 healthy controls were included in the study and CA I and II autoantibody levels were investigated by ELISA. Results: The CA I and II autoantibody levels of BD group were significantly higher than the healthy group (p= 0.013, p= 0.0001, respectively). A cut-off value of 0.250 absorbance unit (ABSU) for anti-CA I was associated with 34% sensitivity and 100% specificity and a cut-off value of 0.171 ABSU for anti-CA II was associated with 54% sensitivity and 100% specificity for predicting BD. Conclusion: The CA I and II autoantibody levels in pa-tients with BD were found higher compared to control group and the results suggest that CA I and II autoantibodies may be involved in the pathogenesis of BD

  AtıfScopus10·WoS9

  İncele
• MakaleYayıncıda açık erişim2013Scopus SJRQ4/r/gumushane/13179
  Serum anti-carbonic anhydrase I and II antibodies and polycystic ovary syndrome; [Serum anti-karbonik anhidraz I ve II antikorları ve polikistik over sendromu]

  Menteşe, Ahmet; Güven, Süleyman; Sümer, Ayşegül; Turan, Ibrahim; Demir, Selim; Karahan, Süleyman Caner; Alver, Ahmet

  Aim: The aim of this study is to investigate anti-carbonic anhydrase antibodies (anti-CA I and CA II antibodies) in the sera of women with polycystic ovary syndrome (PCOS). Methods: In this study serum anti-CA I and II antibody levels of age and BMI matching fifty women with PCOS and fifty women without PCOS on day three of menstrual cycle were assessed with an ELISA method previously developed by Hosoda and modified by Alver et al. Results: The mean serum anti-CA I antibody levels were significantly higher in women with PCOS and anti-CA II antibody levels were not significantly different in women with PCOS compared with control subjects. For serum anti-CA I antibody, the absorbance higher than 0.484 (mean + 3SD of control subjects) was taken as positive, Anti-CA I antibody was detected in 13 of 50 patients with PCOS (26%). Considering serum anti-CA II antibody, the absorbance higher than 0.654 (mean + 3SD of control subjects) was taken as positive. Anti--CA II antibody was detected in 2 of 50 patients with PCOS (4%). All patients with positive anti-CA II antibody also had positive anti-CA I antibody. Autoantibodies specifically reactive to CA I were found to be present at a higher frequency than CA II in the serum of subjects with PCOS in the present study. Conclusion: The results may suggest that autoimmune responses against CA I may be involved in the pathogenesis of PCOS.

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  AtıfScopus9·WoS7·OpenAlex8

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