Sürdürülebilir Kalkınma Amaçları
Yayınlar
- BildiriYalnız künye2025Investigation of antioxidant and antidiabetic activities of propolis obtained from different locations of artvin
Turan, I.; Gultekin, D. Canbolat; Akmese, O.; Gultekin, E.; Demir, S.; Aliyazicioglu, Y.
- BildiriYalnız künye2025Investigation of antioxidant and antidiabetic activities of different extracts of Vitis labrusca fruit peels
Güntekin, D. Canbolat; Akmese, O.; Gültekin, E.; Bak, F. Ersen; Özkan, A. I.; Turan, I.; Demir, S.; Aliyazicioglu, Y.
- MakaleAçık Erişim2017Association of IGF and IGFBP2 gene polymorphisms with growth and egg traits in Atak-S laying hens
Das, Huseyin; Tarim, B.; Demir, S.; Küçükkent, N.; Cengiz, S.; Tülek, E.; Aksakal, V.
Atak-S laying hens are a high-performance hybrid obtained by crossing of the Rhode Island Red (RIR) X the Barred Plymouth Rock (BR) and are being produced in the Ankara Poultry Research Institute since 1997. Phenotypic and genetic improving studies are continuous for this hybrid. In this study three different SNPs, two from IGF1 and one from IGFBP2 genes, were examined in 150 Atak-S chickens. Genetic association of SNPs were compared to body weight and egg number till 32 weeks of age, body weight at sexual maturity, age at sexual maturity and also egg quality traits such as egg shell breaking strength, shell thickness, Haugh unit, albumen index, yolk index and shape index were statistically analyzed. Only IGF1(a) locus was in agreement with Hardy-Weinberg equilibrium, while, the rest of the loci were not. As a result of the comparisons performed to the three SNPs, it was determined that there was a significant association (P < 0.05) between the T364C haplotypes of the IGF1(b) locus and body weight at 32 weeks of age, but there was not any association to the other traits.
- MakaleYalnız künye2017Carbonic anhydrase I and II autoantibodies in Behcet's disease
Mentese, A.; Alver, A.; Demir, S.; Sumer, A.; Yaman S, Ozer; Karkucak, M.; Capkin A, Aydin; Us, Altay D.; Turan, I
Background: Behcet's disease ( BD) is a vasculitis, seen more frequently around the Mediterranean and the Far East, and evinces with oral and genital ulcerations, skin lesions and uveitis. Carbonic anhydrase ( CA) is a metalloenzyme which is widely distributed in the living world, and it is essential for the regulation of acid-base balance. Anti-CA antibodies have been reported in many disorders, such as systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, endometriosis, idiopathic chronic pancreatitis, type 1 diabetes and Graves' disease. The goal of this study was to investigate CA I and II autoantibodies in BD. Methods: 35 patients with BD and 29 healthy controls were included in the study and CA I and II autoantibody levels were investigated by ELISA. Results: The CA I and II autoantibody levels of BD group were significantly higher than the healthy group (p= 0.013, p= 0.0001, respectively). A cut-off value of 0.250 absorbance unit (ABSU) for anti-CA I was associated with 34% sensitivity and 100% specificity and a cut-off value of 0.171 ABSU for anti-CA II was associated with 54% sensitivity and 100% specificity for predicting BD. Conclusion: The CA I and II autoantibody levels in pa-tients with BD were found higher compared to control group and the results suggest that CA I and II autoantibodies may be involved in the pathogenesis of BD
- BildiriYalnız künye2016Selective cytotoxic effect of Morus rubra extract in human lung cancer cells through enhancing apoptosis and cell cycle arrest
Turan, I.; Demir, S.; Kilinc, K.; Aliyazicioglu, Y.; Alver, A.; Misir, S.; Yaman, S. Ozer; Akbulut, K.; Deger, O.
- BildiriYalnız künye2016Automatic segmentation of plaque and four-dimensional analysis of magnetic resonance images used in the diagnosis and disease monitoring of multiple sclerosis
Demir, S.; Bayram, B.; Demir, N.; Catal, H.; Togrol, R. E.; Kafadar, C.; Ozdag, M. F.
- BildiriYalnız künye2016The epithelizan effect of the Morus nigra extracts on rats
Kilinç, K.; Turan, I.; Özgen, U.; Livaoglu, M.; Ural, A.; Sener, S. O.; Kara, H.; Efe, G.; Demir, S.
- MakaleYalnız künye2011Preventive and protective effects of turkish propolis on H 2O 2-induced DNA damage in foreskin fibroblast cell lines
Aliyazicioglu, Yuksel; Demir, S.; Turan, I.; Cakiroglu, Tugba; Akalin, I.; Deger, O.; Bedir, A.
The aim of the present study was to evaluate the potential of Turkish propolis extracts if they prevent or protect foreskin fibroblast cells against hydrogen peroxide (H 2O 2)-induced oxidative DNA damage. Hydrogen peroxide (40 μM) was used as an inducer of oxidative DNA damage. The damage of DNA was evaluated by using the alkaline single cell gel electrophoresis (comet) assay. Turkish propolis extracts at concentrations of 25, 50, 75 and 100 μg/ml were prepared by ethanol. Anti-genotoxicity was assessed before, simultaneously, and after treatment of propolis extract (50 μg/ml) with H 2O 2. The results showed a significant decrease in H 2O 2-induced DNA damage in cultures treated with propolis extract. The antioxidant activity of phenolic components found in propolis may contribute to reduce the DNA damage induced by H 2O 2. Our findings confirmed the chemopreventive activity of propolis and showed that this effect may occur under different mechanisms.