Sürdürülebilir Kalkınma Amaçları

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Araştırmacılar(20)

• Akbaba, Yusuf
• Bastem, Enes
• Bingöl, Nurhan Değirmenci
• Bozkır, İsa
• Coşar, Dilan Aktepe
• Demirtaş, Sedef Alataş
• Duru, Gökcem
• Gençosmanoğlu, Merve
• Göksu, Süleyman
• Gülçin, Ilhami
• Hamzaoğlu, Elif Buşra
• Karaoğlu, Olcay
• Kardil, Uğur
• Kurt, Kemal
• Kurt, Pınar
• Marasç, Ahmet
• Şahin, Meltem
• Topal, Meryem
• Yalvaç, Yaprak İlayda
• Yüksel, Duygu

• MakaleAçık Erişim2027/r/gumushane/13442
  Design, Synthesis, and X-ray Characterization of Benzohydrazide Derivatives as Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease: An Experimental and Computational Approach to Biological Activity

  Topal, Fevzi; Ünver, Hakan; Topal, Meryem; Çevik, Ulviye Acar; Kırboğa, Kevser Kübra; Işık, Mesut; Beydemir, Şükrü

  In this study, a series of new benzohydrazide derivatives (1a-i) were synthesized, and characterized as potential cholinesterase inhibitors for use in the treatment of Alzheimer’s disease (AD). The inhibitory activities of the synthesized compounds against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were evaluated using in vitro and in silico methods. IC50 values for AChE inhibition ranged from 29.50 to 46.21 nM, with compound 1c exhibiting the highest inhibitory potential at an IC50 of 29.50 nM. For the BChE enzyme, the strongest effect was observed with compound 1d at an IC50 of 55 nM. The synthesized derivatives exhibited higher inhibitory potential compared to the reference tacrine (IC50: 58.73 nM for AChE and 187.30 nM for BChE) against cholinesterase enzymes through both competitive and non-competitive inhibition mechanisms. Molecular docking (ΔG: -10.67 to -9.95 kcal/mol for AChE; -9.80 to -8.69 kcal/mol for BChE) and 100 ns molecular dynamics simulations supported the binding affinities and indicated the dynamic stability of the enzyme-inhibitor complexes, in agreement with the experimental inhibition data. In silico ADMET profiling indicated favourable drug-likeness and high predicted gastrointestinal absorption and blood-brain barrier permeability (TPSA 41.46-61.69 A2), and structural alert screening returned no PAINS matches. The findings suggest that these derivatives may serve as promising lead compounds for further investigation as potential cholinesterase inhibitors relevant to AD, pending experimental cytotoxicity evaluation.

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• MakaleYalnız künye2026/r/gumushane/10493
  Novel Approach to Synthesis of Diaryl Tacrine Derivatives and Evaluation of Their Inhibitory Effects on Cholinesterase Enzymes

  Topal, Fevzi; Ökten, Salih; Misir, Busra Albayrak; Koçyigit, Umit Muhammet; Derin, Yavuz; Atalay, Vildan Enisoglu; Tutar, Ahmet; Topal, Meryem

  The development of effective acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors remains a crucial objective in the treatment of neurodegenerative diseases, including Alzheimer's disease (AD). In this study, a novel synthetic approach was established to prepare a series of diaryl-substituted tacrine derivatives. Initially, brominated aminobenzonitrile was subjected to Suzuki-Miyaura cross-coupling reactions with various aryl boronic acids to yielding diaryl-substituted aminobenzonitriles at yields of 60%-72%. These intermediates were then cyclized with cyclohexanone and cycloheptanone under Friedl & auml;nder conditions using BF3 & centerdot;OEt2 as a catalyst, affording six- and seven-membered diaryl tacrine analogues in yields of 52%-68%. All synthesized compounds were characterized by NMR, IR, and elemental analysis. The inhibitory activities of these compounds (7-16) against AChE and BChE were evaluated, and several analogs demonstrated potent dual-enzyme inhibition at nanomolar concentrations. Notably, compounds 8 and 13 exhibited half maximal inhibitory concentration (IC50) values of 6.848 and 8.545 nmol/L for BChE, respectively, indicating strong potential as selective cholinesterase inhibitors. The structure-activity relationship (SAR) analysis revealed the influence of aryl substituents on the potency and selectivity of enzyme inhibition. Compared to previously reported tacrine derivatives, the newly synthesized analogs exhibited superior inhibitory profiles, indicating their potential as lead compounds for further development in AD therapeutics. [GRAPHICS] .

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• MakaleAçık Erişim2026/r/gumushane/19466
  Comparison of Online and Hybrid Education Models for First Aid and Emergency Care Students

  Karabela, Semsi Nur; Kahraman, Beliz Yekeler; Değirmenci Bingöl, Nurhan; Döğer, Berna Nur Berker

  Background: The Coronavirus Disease 2019 pandemic disrupted education and training processes, necessitating a transition to remote learning that significantly altered teaching methods for both students and instructors. To highlight the challenges arising from this rapid shift in applied health sciences, the present study aimed to compare the perceptions of professional competence among First and Emergency Aid students who received online versus hybrid education during the pandemic. Materials and Methods: This descriptive cross-sectional study was conducted among second-year students at two universities: one providing fully online education (n = 59) and the other offering hybrid instruction (n = 61). Results: No statistically significant difference was observed between the groups in understanding theoretical courses (p = 0.088); however, students who received face-to-face instruction within the hybrid model demonstrated significantly better comprehension of practical courses (p < 0.001). Conclusion: In conclusion, while online education is adequate for acquiring theoretical knowledge, it is insufficient for developing clinical and technical skills. Accordingly, these findings suggest that practical courses in health education programs, such as First and Emergency Aid, should be conducted face-to-face whenever possible; when in-person attendance is required, appropriate safety measures should be implemented.

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• MakaleAçık Erişim2026/r/gumushane/13908
  Electric field–induced inflammatory and angiogenic responses in rat female reproductive tissues: evidence for early extracellular matrix remodeling

  Ozmen, Ozlem; Asci, Halil; Kolay, Oznur; Selcuk, Elif Nur; Yuksel, Duygu; Comlekci, Selcuk; Karabacak, Pinar

  High-intensity electric fields (EFs) are increasingly encountered in occupational and environmental settings, raising concerns regarding their potential biological effects on hormonally responsive organs. However, the cellular and molecular responses of female reproductive tissues to short-term exposure to high-voltage EFs remain insufficiently characterized. This study aims to investigate EF-associated histopathological and immunohistochemical alterations in major female reproductive organs. Forty adult female Wistar albino rats were randomly assigned to five experimental groups (n = 8 per group): a control group (0 min) and four EF-exposed groups subjected to a nominal electric field intensity of 10 kV/m EF for 1, 5, 15, or 30 min using a custom-designed parallel-plate exposure system. The field intensity was verified at predefined measurement points within the exposure setup. Ovaries, uterus, and uterine tubes were examined using hematoxylin–eosin staining and semi-quantitative histopathological scoring. Immunohistochemical analyses were performed to evaluate the expression of tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), and osteonectin as markers of inflammation, angiogenesis, and extracellular matrix remodeling. Exposure to the electric field was associated with time-dependent histopathological alterations, including tissue edema, hemorrhage, epithelial degeneration, and leukocyte infiltration. The most pronounced ovarian and uterine changes were observed in the 30-min exposure group, whereas the uterine tubes exhibited comparatively milder structural alterations. Immunohistochemical analysis demonstrated increased TNF-α and VEGF expression in higher-exposure groups, suggesting activation of inflammatory and angiogenic pathways. Osteonectin expression was elevated in all examined reproductive tissues and was also detected in regions without overt morphological damage, indicating its potential sensitivity to early tissue stress responses associated with EF exposure. Significant correlations were observed between histopathological injury scores and immunohistochemical marker expression levels. Overall, short-term exposure to high-intensity electric field was associated with inflammatory signaling, angiogenic responses, and extracellular matrix remodeling in female reproductive tissues in this experimental model. These findings provide histological and immunohistochemical evidence of tissue responses to EF exposure and underscore the need for further studies incorporating comprehensive exposure characterization and additional molecular endpoints to better define potential reproductive health implications to high-voltage electric fields.

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• MakaleYalnız künye2026/r/gumushane/13873
  Effects of a puppet-assisted house-tree-person test on fear and anxiety in children receiving chemotherapy and associated influencing factors: A projective, quasi-experimental study

  KAHRIMAN, Ilknur; AKSOY, Bahar; KANDAZ, Ufuk; BORAN, Serpil; GÖGER, Berrin; KIRBAŞ, Zila Özlem

  Objectives This study investigated the effect of the puppet-assisted House-Tree-Person Test (HTP-T) on fear and anxiety levels in children undergoing chemotherapy treatment and the factors influencing these outcomes. Methods The study employed a one-group pretest–posttest quasi-experimental design combined with HTP-T analysis. The study was conducted with 29 children aged 5–12 years receiving chemotherapy at the pediatric hematology-oncology outpatient clinics of a university hospital in the Eastern Black Sea Region of Türkiye during the 2022–2024 years. Data were collected using “the Demographic Information Form for Children and Parents, the Children's State Anxiety Scale (CSA), the Children's Fear Scale (CFS), and HTP-T". Data analysis was performed using descriptive statistics, repeated measures ANOVA, and HTP-T analysis. Results Statistically significant differences were observed in children's mean CSA (F = 3.898, p = 0.026, η2 = 0.122) and CFS (F = 5.313, p = 0.008, η2 = 0.159) scores across the pre-treatment, during-treatment, and post-treatment measurements. The HTP-T analysis revealed that children had difficulty regulating anxiety and fear, expressed concerns about family and environmental events, reported feelings of loneliness, and exhibited strong emotional attachment to their families. Conclusion The study demonstrated that incorporating puppet-assisted HTP-T during chemotherapy contributed to reducing children's fear and anxiety and offered a useful approach for identifying influencing factors. Implications for nursing practice HTP-T, a therapeutic play technique incorporating puppetry and projective methods, may be effective in reducing fear and anxiety among children undergoing chemotherapy.

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• MakaleYalnız künye2026/r/gumushane/13698
  In sepsis-associated cardiotoxicity, remifentanil reduces oxidative stress, inflammation, and apoptosis to maintain mitochondrial biogenesis by inhibiting NFkB and cas-3 immunoexpressions and enhancing SIRT1 upregulation

  Tepebaşi, Muhammet Yusuf; Aşci, Halil; Selçuk, Esma; Uysal, Dinçer; Bindal, Ahmet; Yüksel, Duygu; Özmen, Özlem

  Objective: Sepsis-induced cardiotoxicity (SIC) is a critical complication characterized by inflammation, oxidative stress, and apoptosis, leading to myocardial dysfunction. The short-acting opioid analgesic remifentanil (REMI) possesses antioxidant and anti-inflammatory properties. This study aimed to evaluate the cardioprotective effects of REMI on lipopolysaccharide (LPS)-induced SIC by examining inflammation, oxidative stress, apoptosis, and mitochondrial function. Materials and methods: Thirty-two female Wistar albino rats were divided into four groups: control, lipopolysaccharide (LPS), LPS+REMI, and REMI. Myocardial and aortic tissues were analyzed for histopathology, immunoexpression of Caspase-3 (Cas-3), nuclear factor kappa beta (NF-κB), and tumor necrosis factor alpha (TNF-α). Oxidative stress markers, including total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI), were measured. Mitochondrial apoptosis-related gene expression of AMP-activated protein kinase (AMPK), BCL2 Associated X (BAX), B-cell lymphoma 2 (BCL-2), Sirtuin 1 (SIRT1), and Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) was assessed. Results: LPS administration induced severe histopathological damage, increased oxidative stress (elevated TOS and OSI), and upregulated apoptotic (Cas-3, BAX/BCL-2 imbalance) and inflammatory (NF-κB, TNF-α) markers. REMI treatment significantly alleviated myocardial and aortic injury, reducing the histopathological score. It markedly decreased Cas-3, NF-κB, and TNF-α expression, lowered TOS and OSI levels, and modulated the BAX/BCL-2. Furthermore, REMI restored the expression of AMPK, SIRT1, and PGC-1α genes, indicating a protective effect on mitochondrial biogenesis and energy metabolism. Conclusions: REMI exhibits significant cardioprotective effects in LPS-induced SIC by attenuating inflammation, oxidative stress, and apoptosis while preserving mitochondrial homeostasis.

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• MakaleYalnız künye2026/r/gumushane/13649
  Changes in BMI, lipid profile, disease perception, and quality of life among myocardial infarction patients participating in a 12-week green walking: A quasi-experimental study

  Cin, Aynur; Hintistan, Sevilay

  Objective This study assessed the 12-week intervention of green walking on BMI, blood lipids, disease perception, and quality of life among myocardial infarction patients. Methods In a quasi-experimental design, 60 participants (28 men, 32 women; aged 36–77 years) were assigned to intervention (green walk) or control (routine care) groups based on geographic convenience. The green walking group performed high-intensity interval walking for 50 min three times a week in a natural setting for 12 weeks. Adherence was monitored via attendance logs, with a mean of 91.7 % (SD 7.1 %). Primary outcomes included BMI and lipid profiles, while secondary outcomes included perceived illness and quality of life, assessed through validated questionnaires. A mixed-design model incorporating time-group interaction was used for analysis. Data were analyzed using mixed-design ANOVA, repeated-measures ANOVA, paired t-tests, Friedman tests, and Wilcoxon tests. Results The green walk group showed improvements in several measures including a reduction in BMI and positive changes in lipid profiles and disease perception scores with enhanced quality of life for both groups. The mean differences between groups for weight, BMI, and concerns over medication were not significant. No severe adverse events were recorded during the entire 12-week program. Conclusions Participation in the green walking program for 12 weeks is associated with favorable trends in BMI, lipid levels, disease perception, and quality of life among myocardial infarction patients which structured green walking can be an aid toward improving well-being during cardiac rehabilitation; however further randomized controlled studies will substantive such an association.

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• MakaleYalnız künye2026/r/gumushane/13628
  The relationship between compassion fatigue and levels of depression, anxiety, and stress in nurses: A multicenter cross-sectional study

  Coşar, Dilan Aktepe; Ayyıldız, Neşe Işcan; Şimşekli, Derya

  Aim This study aimed to investigate the relationship between compassion fatigue and depression, anxiety, and stress levels in nurses. Method This research is a multicenter, cross-sectional study. The study was conducted with 283 nurses in three state hospitals in northeastern Turkey using a purposive sampling method. Research data were collected by the researchers using a Demographic Form, the Compassion Fatigue Scale (CFS), and the Depression, Anxiety, Stress Scale (DASS-21). Descriptive statistics, normality assessment, one-way ANOVA, t -tests, Pearson correlation and multiple linear regression analysis were performed using SPSS 26 software. Results A total of 283 nurses participated in the study. The mean CFS score was 83.97 ± 13.76, while the mean DASS-21 scores were 8.05 ± 4.10 for depression, 4.89 ± 2.97 for anxiety, and 9.22 ± 4.32 for stress. Correlation and regression analyses revealed a strong positive correlation between compassion fatigue and depression (r = 0.574, p < 0.001), a moderate positive correlation with anxiety (0.349, p < 0.001), and a strong positive correlation with stress (0.583, p < 0.001). Multiple regression analysis revealed that depression, stress, male gender, working as a nursing education specialist, and job dissatisfaction were variables significantly associated with compassion fatigue. Conclusion Based on these results, it is necessary to evaluate compassion fatigue in nurses in conjunction with psychological factors as well as individual and professional characteristics. Furthermore, it is important to support nurses' psychological health, develop strategies to address compassion fatigue, and increase individual resilience.

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• MakaleYalnız künye2026/r/gumushane/13472
  Effects of sunlight ripening process on the biological activities of persimmon (Diospyros kaki L.) peel and pulp extracts

  Kardil, Uğur; Akar, Zeynep; Düzgün, Azer Özad

  The aim of the study was to evaluate the biological properties of the peel and pulp extracts of persimmons, with consideration of the impact of different ripening conditions (B: on-branch ripened and S: sunlight ripened). The data demonstrated that the sunlight ripened persimmon peel (S. peel) extract exhibited a higher total phenolic and flavonoid content, with 157 and 7.3 µg/mL GAE respectively. The S. peel extract exhibited the highest antioxidant activity, exhibiting 1.1578 mg/mL IC50, 54.095 and 0.0262 µM Trolox equivalent (TE)/g fresh weight (FW), as determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH•) radical scavenging assay, ferric reducing antioxidant power (FRAP) and cupric reducing antioxidant capacity (CUPRAC) respectively. LC-MS/MS analysis revealed that the peel and pulp phenolic composition of persimmon ripening process different conditions changed. The activity of protocatechuic, chlorogenic, caffeic and ferulic acids identified in persimmon extracts was determined by HPLC-DAD-FRAP assay. ICP-OES analysis revealed that potassium exhibited the highest mineral content of persimmon, with values ranging from 575.680 to 2031.360 mg/kg. The S. peel extract was more inhibitory activity against bovine carbonic anhydrase (BCA) and α-glucosidase then other extracts. Moreover, the S. peel extract was found to demonstrate the highest level of antibiofilm activity, reducing the strong biofilm formation capacity of the A. baumannii isolate to negative, both qualitatively and quantitatively. The study suggests that the ripening of persimmon fruit in sunlight may increase biological activity and may be useful in the prevention and treatment of diseases associated with oxidative damage, diabetes and bacterial infections.

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• MakaleYalnız künye2026/r/gumushane/13459
  Nurses' artificial intelligence anxiety levels, their attitudes towards artificial intelligence, and their skills in acting humanistically in nursing practices

  Cin, Aynur; Coşar, Dilan Aktepe; Demirağ, Hatice

  Aim This study aims to investigate the levels of artificial intelligence-related anxiety among nurses, their attitudes towards the use of AI in clinical settings, their ability to maintain humanistic approaches in nursing care, and the interrelationships among these variables. Design This study was designed as a descriptive and cross-sectional pilot study. Method The sample of the descriptive study consisted of 267 nurses working in X and Y hospitals in Gümüşhane province. The data of the research was collected between December 2023 and May 2024 using the “Nurse Introduction Form”, “Artificial Intelligence Anxiety Scale”, “General Attitude Scale towards Artificial Intelligence” and “Humanistic Practice Ability of Nursing”. Results Total “Artificial Intelligence Anxiety Scale” mean scores were found to be higher in nurses who were women, and had more than five years of working experience ( p < 0.05). It was determined that the total “General Attitude Scale Towards Artificial Intelligence” score averages of nurses working in surgical clinics were higher than those working in pediatric clinics ( p < 0.05). Positive “General Attitude Scale Towards Artificial Intelligence” mean scores were higher in nurses who had a postgraduate degree, worked in a surgical clinic, and had five years or less experience ( p < 0.05). Again, the total mean of the “ Humanistic Practice Ability of Nursing “ was higher in nurses who had a bachelor's degree or less, and worked in management and surgery clinics ( p < 0.05). Conclusion It was found that nurses' artificial intelligence anxiety, general attitudes towards artificial intelligence, and ability to act humanistally varied according to some sociodemographic characteristics.

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