Sürdürülebilir Kalkınma Amaçları
Yayınları
1 →- MakaleYalnız künye2014Synthesis and carbonic anhydrase inhibitory effects of novel sulfamides derived from 1-aminoindanes and anilines
Akbaba, Yusuf; Bastem, Enes; Topal, Fevzi; Gülçin, Ilhami; Marasç, Ahmet; Göksu, Süleyman
Three 1-aminoindanes, four anilines and BnOH or t-BuOH were reacted with chlorosulfonyl isocyanate to give sulfamoyl carbamates. Pd-C catalysed hydrogenolysis reactions of carbamates or deprotection of the Boc group of the carbamates with CF3CO2H afforded seven novel sulfamides. Human carbonic anhydrase (hCA) isoenzymes I and II (hCA I and hCA II) were purified from fresh human blood erythrocytes with onestep affinity chromatography on Sepharose 4B-tyrosine-sulfanilamide. The inhibitory properties of the novel sulfamides on both isoenzymes were determined using the esterase activity with 4-nitrophenyl acetate (NPA) as substrate. The tested novel sulfamides derived from 1-aminoindanes and anilines effectively inhibited hCA I and II competitively in the nanomolar range. Among these compounds, the novel sulfamide derivative 17 showed themost potent inhibitory effect against hCA I (Ki: 153.88 nM), while sulfamide derivative 26 showed the highest inhibitory potential against hCA II (Ki: 117.80nM).
Tam Kayıt
| Alan | Değer | Dil |
|---|---|---|
| dc.date.accessioned | 2026-10-22T10:24:08.550162712Z | |
| dc.date.available | 2026-10-22T10:24:08.550162712Z | |
| dc.identifier.uri | https://rdlopen.rawdatalibrary.net/r/gumushane/15525 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.title | Bastem, Enes | |
| dspace.entity.type | Person | |
| person.affiliation.name | Department of Medical Services and Techniques, Vocational School of Health Services, Gumushane University Gumushane, Türkiye | |
| person.familyName | Bastem | |
| person.givenName | Enes | |
| person.identifier.scopus | 56437719900 | |
| person.status | unverified |