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Koleksiyondaki öğeler
- MakaleAçık Erişim2014Scopus SJRQ1Physicochemical, bioactive, and sensory properties of persimmon-based ice cream: Technique for order preference by similarity to ideal solution to determine optimum concentration
Karaman, Safa; Toker, Ömer Said; Yüksel, Ferhat; Çam, Mustafa; Kayacier, Ahmed; Dogan, Mahmut
In the present study, persimmon puree was incorporated into the ice cream mix at different concentrations (8, 16, 24, 32, and 40%) and some physicochemical (dry matter, ash, protein, pH, sugar, fat, mineral, color, and viscosity), textural (hardness, stickiness, and work of penetration), bioactive (antiradical activity and total phenolic content), and sensory properties of samples were investigated. The technique for order preference by similarity to ideal solution approach was used for the determination of optimum persimmon puree concentration based on the sensory and bioactive characteristics of final products. Increase in persimmon puree resulted in a decrease in the dry matter, ash, fat, protein contents, and viscosity of ice cream mix. Glucose, fructose, sucrose, and lactose were determined to be major sugars in the ice cream samples including persimmon and increase in persimmon puree concentration increased the fructose and glucose content. Better melting properties and textural characteristics were observed for the samples with the addition of persimmon. Magnesium, K, and Ca were determined to be major minerals in the samples and only K concentration increased with the increase in persimmon content. Bioactive properties of ice cream samples improved and, in general, acetone-water extracts showed higher bioactivity compared with ones obtained using methanol-water extracts. The technique for order preference by similarity to ideal solution approach showed that the most preferred sample was the ice cream containing 24% persimmon puree.
AtıfScopus123WoS109OpenAlex168
İncele - MakaleYalnız künye2011Scopus SJRQ3Aromatisation in adducts of a-terpinene: Influence of hindered internal Rotations
Kaya, Afşin Ahmet; Şengül, Mehmet Emin; Menzek, Abdullah; Kayaardi, Ibrahim; Karakuş, Murat; Şahin, Ertan
Each adduct of α-terpinene with p-quinone and 1,4-naphthoquinone in Ac2O/Et3N at 180 °C gives two aromatic products, one of which had a distinctive smell formed by the loss of an ethylene group. Here, we report the crystal structure of (1RS, 4RS)-1-isopropyl-4-methyl-1,4-dihydro- 1,4-ethanoanthracene-9,10-diyl diacetate. It is crystallised in an orthorhombic space group, Pbca, with cell dimensions a = 10.2899(7), b = 19.7804(9), c = 19.7519(8) Å and Z = 8. According to its NMR and X-ray diffraction data, the isopropyl and acetate groups slowly rotate.
AtıfScopus4WoS4OpenAlex2İncele - MakaleYalnız künye2013Scopus SJRQ3Assessment of heavy metal accumulation in the roadside soil and plants of Robinia pseudoacacia, in Gumushane, Northeastern Turkey; [Yol kenari{dotless}ndaki topraklarda ve Robinia pseudoacacia bitkilerindeki aǧi{dotless}r metal birikiminin deǧerlendirilmesi, Gümüşhane, kuzeydoǧu Türkiye]
Vural, Alaaddin
The concentrations of heavy elements were studied in the soils and plants of Robinia pseudoacacia, along a highway passing through Gümüşhane City Center, Turkey. The aim of this study is to understand heavy metal accumulation due to dense traffic load, industrialization, urbanization, and/or geological features of the region. The assessment of the heavy metal accumulation of the soils is based on the Geoaccumulation Index and Enrichment Factor, and that of plants, is based on the Bioaccumulation Factor. According to the Geoaccumulation Index, soil samples were uncontaminated for Cr, Co, Cu, Rb, and Sr elements, uncontaminated to moderately contaminated for V, Ni, Ba, and Zn, and moderately to heavily-heavy contaminated for As. The contamination of soil samples changes from moderate-heavy-extremely contaminated degree for Pb. According to the Enrichment Factor; soil samples show, no enrichment-moderately-severe enrichment for V. Considering the Zn element, enrichment is in minor to severe enrichment. On the other hand, element enrichment is severe to very severe enrichment for As and that of Pb is minor to an extremely severe enrichment level. The data revealed that the soil in the study area is significantly contaminated for Zn, As, and Pb. Also, concentration levels of Cu, Fe, Mo, Ni, Sr, and Zn in the shoots of Robinia pseudoacacia at some location were determined as above and/or exceeded the upper limit of the normal range.
AtıfScopus16WoS22OpenAlex30İncele - MakaleAçık Erişim2011Scopus SJRQ1The effect of material properties on the seismic performance of Arch Dams
Sevim, B.
The paper investigates the effect of material properties on the seismic performance of arch dam-reservoir-foundation interaction systems based on the Lagrangian approach using demand-capacity ratios. Type-5 arch dam is selected as a numerical application. The linear time history analyses of the arch dam-reservoir-foundation interaction system are carried out for different material properties. The foundation is taken into account as massless; behaviour of the reservoir is assumed to be linearly elastic, inviscid and irrotational. The north-south component of the Erzincan earthquake in 1992 is chosen as a ground motion. Dynamic equations of motions obtained from 3-D finite element modelling of the coupled system are solved by using the Newmark integration algorithm. The damage levels of the coupled system for the different material properties are demonstrated by using demand-capacity ratios and cumulative inelastic durations. The time histories and maximum values of the displacements and principal stresses, and performance curves, are obtained from linear analyses. It is clearly seen from the study that the different material properties affect the seismic behaviour of the dam.
AtıfScopus10WoS9OpenAlex7İncele - MakaleYalnız künye2015Scopus SJRQ1Geochronology, geochemistry, and petrogenesis of the Eocene Bayburt intrusions, Eastern Pontides, NE Turkey: Evidence for lithospheric mantle and lower crustal sources in the high-K calc-alkaline magmatism
Kaygusuz, Abdullah; Öztürk, Mürşit
Eocene I-type plutons are widespread in the Eastern Pontides, Northeastern Turkey. Geochemical and isotopic results on two Eocene intrusive bodies located in the southern zone of the Eastern Pontides were utilized to achieve a proper reconstruction of their origin. Based on laser ablation ICP-MS U-Pb zircon dating, Kiliçkaya and Kozluk intrusions present similar 206Pb/238U versus 207Pb/235U concordia ages of 46.75±0.79 and 46.9±0.68 Ma, respectively. Both intrusions exhibit similar petrographical, geochemical, and isotopical features, and contain abundant mafic microgranular enclaves (MMEs). The intrusive rocks are composed of diorite, tonalite, and granodiorite, whereas MMEs are composed of diorite. Both the intrusive rocks and the MMEs are I-type, high-K calc-alkaline in composition and display a metaluminous character. They are enriched in large-ion lithophile and light rare-earth elements and are depleted in high-field strength elements. The intrusive rocks show moderate variation in 87Sr/86Sr(i) (0.70531-0.70576), εNd(i) (+0.3 to -0.5), and δ18O values (+6.6 to +6.9), as well as Nd model ages (0.73-0.82Ga). Their Pb isotopic ratios are 206Pb/204Pb=18.67-18.86, 207Pb/204Pb=15.61-15.62, and 208Pb/204Pb=38.62-39.03. Although the isotope signatures of MMEs (87Sr/86Sr(i)=0.70528-0.70561; εNd(i)=+0.7 to -0.3; δ18O=+6.7 to +6.8) are significantly similar to those of the host rocks, the MMEs are characterized by relatively low contents of SiO2 (57-59wt.%), low aluminum saturation index (0.8-0.9), and high Mg numbers (31-36). All of these data suggest magma generation by mixing of enriched lithospheric mantle- and lower crustal-derived melts. Moreover, Sr-Nd isotopic modeling reveals ~17% to 23% lower crustal magma contribution to the mantle component.
AtıfScopus59WoS58OpenAlex62İncele - MakaleYalnız künye2013Scopus SJRQ2Determination of Pb(II), Zn(II), Cd(II), and Co(II) ions by flame atomic absorption spectrometry in food and water samples after preconcentration by coprecipitation with Mo(VI)-diethyldithiocarbamate
Tufekci, Mehmet; Bulut, Volkan Numan; Elvan, Hamide; Ozdes, Duygu; Soylak, Mustafa; Duran, Celal
A new, simple, and rapid separation and preconcentration procedure, for determination of Pb(II), Cd(II), Zn(II), and Co(II) ions in environmental real samples, has been developed. The method is based on the combination of coprecipitation of analyte ions by the aid of the Mo(VI)-diethyldithiocarbamate- (Mo(VI)-DDTC) precipitate and flame atomic absorption spectrometric determinations. The effects of experimental conditions like pH of the aqueous solution, amounts of DDTC and Mo(VI), standing time, centrifugation rate and time, sample volume, etc. and also the influences of some foreign ions were investigated in detail on the quantitative recoveries of the analyte ions. The preconcentration factors were found to be 150 for Pb(II), Zn(II) and Co(II), and 200 for Cd(II) ions. The detection limits were in the range of 0.1-2.2 μg L-1 while the relative standard deviations were found to be lower than 5 % for the studied analyte ions. The accuracy of the method was checked by spiked/recovery tests and the analysis of certified reference material (CRM TMDW-500 Drinking Water). The procedure was successfully applied to seawater and stream water as liquid samples and baby food and dried eggplant as solid samples in order to determine the levels of Pb(II), Cd(II), Zn(II), and Co(II) ions.
AtıfScopus33WoS28OpenAlex30İncele - MakaleYalnız künye2014Scopus SJRQ3Geochemistry of dacitic volcanics in the Eastern Pontides (NE Turkey)
Sipahi, Ferkan; Sadıklar, M.Burhan
Dacitic rocks that crop out around the Zigana Mountain (Gümüşhane) in the eastern Pontide (NE Turkey), are mainly composed of quartz, plagioclase, sanidine, amphibole, muscovite, and biotite as the main minerals. Zircon and rutile are the accessory minerals. Pyrite, chalcopyrite, and covellite are the opaque components. On the basis of trace-element data, dacites have been classified as Dacite-I and Dacite-II. Dacite-I is tholeitic-transitional, whereas Dacite-II is transitional-calc-alkaline. The geochemical variation can be explained by the fractionation of the common mineral phases, such as plagioclase, hornblende, magnetite, and apatite. Dacites also show island-arc properties, with negative Nb, Sr, P, and Ti anomalies. The trace-element distrubitions of the dacitic rocks reflect the typical characteristics of rocks from the subduction-related tectonic setting, with enrichment of large-ion lithofile elements and light rare-earth element, but depletion in high-field-strength elements. The dacitic rocks are developed through plagioclase ± hornblende-controlled fractionation from the same parental magma that settled in two successive stages and are derived from an enriched source, probably by the mixing of slab-derived and lithospheric melts.
AtıfScopus18WoS15İncele - MakaleYalnız künye2015Scopus SJRQ1Effect of domestic cooking methods on antioxidant capacity of fresh and frozen kale
Ilyasoʇlu, Huri; Burnaz, Nesibe Arslan
The aim of this study was to evaluate the changes in the antioxidant capacity of fresh and frozen kale during domestic cooking methods (e.g., boiling, microwaving, and steaming). The antioxidant activities of the samples were measured using three in vitro assays (1,1-diphenyl-2-picrylhydrazyl assay, 2, 2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid assay, and ferric reducing antioxidant power assay). The steaming treatment was found to be the best cooking method to retain antioxidant compounds, followed by the microwaving and boiling treatments. The frozen uncooked samples exhibited a higher antioxidant capacity than the fresh, uncooked samples, indicating that the freezing process could enhance the antioxidant capacity of the kale.
AtıfScopus21WoS19OpenAlex25İncele - MakaleAçık Erişim2013Scopus SJRQ2Estimation of the soil strength parameters in Tertiary volcanic regolith (NE Turkey) using analytical hierarchy process
Ersoy, Hakan; Betül Karsli, Melek; Çellek, Seda; Kul, Bilgehan; Baykan, Idris; Parsons, Robert L.
Costly and time consuming testing techniques and the difficulties in providing undisturbed samples for these tests have led researchers to estimate strength parameters of soils with simple index tests. However, the paper focuses on estimation of strength parameters of soils as a function of the index properties. Analytical hierarchy process and multiple regression analysis based methodology were performed on datasets obtained from soil tests on 41 samples in Tertiary volcanic regolith. While the hierarchy model focused on determining the most important index properties affecting on strength parameters, regression analysis established meaningful relationships between strength parameters and index properties. The negative polynomial correlations between the friction angle and plasticity properties, and the positive exponential relations between the cohesion and plasticity properties were determined. These relations are characterized by a regression coefficient of 0.80. However, Terzaghi bearing capacity formulas were used to test the model. It is important to see whether there is any statistically significant relation between the calculated and the observed bearing capacity values for model testing. Based on the model, the positive linear correlation characterized by the regression coefficient of 0.86 were determined between bearing capacity values obtained by direct and indirect methods.
AtıfScopus10WoS10OpenAlex14İncele - MakaleYalnız künye2015Scopus SJRQ3Synthesis, X-Ray Structural, Characterization, NLO, MEP, NBO, and HOMO-LUMO Analysis Using DFT Study of Co(II)bis(3,4 dimethoxybenzoate)bis(nicotinamide) Dihydrate
Kaya, Elif Çelenk; Demircioʇlu, Zeynep; Kaya, Afşin Ahmet; Büyükgüngör, Orhan
A suitable single crystal of Co(II)bis(3,4 dimethoxybenzoate)bis(nicotinamide) dihydrate, formulated as C30H38N4O14Co,(I). According to experimental data, the complex can be characterized in the solid state as mononuclear, with a distorted octahedral stereochemistry. The distorted octahedral stereochemistry adopted by the complex was further confirmed by the x-ray structure analysis of current study, which consists of a six-coordinate Co atom in a distorted octahedral environment constructed from two N atoms and four O atoms. The title compound which has been characterized by IR, UV, and single crystal X-ray diffraction analysis at 296 K crystallizes in the monoclinic space group C 2/c with a = 27.9402(15) Å, b = 8.6005(3)Å, c = 14.7921(9)Å, α = 90°, β = 108.849(4)°, and γ = 90°, Z = 4. The molecular structure and geometry have also been optimized using B3LYP density functional theory method employing the 6-31G (d) basis set. The molecular electrostatic potential (MEP), frontier molecular orbitals (FMO) analysis, nonlinear optical properties (NLO), and natural bond analysis (NBO) for the title molecule are also described from the computational process.
AtıfScopus9WoS10OpenAlex11İncele - MakaleYalnız künye2011Scopus SJRQ1Restructuring of Turkey's electricity market and the share of hydropower energy: The case of the Eastern Black Sea Basin
Uzlu, Ergun; Akpinar, Adem; Kömürcü, Murat Ihsan
This paper presents the historical development of Turkey's electricity power sector, the efforts for introducing competition in the power industry in Turkey, and the concerns regarding restructuring in Turkey. The contribution of the hydropower energy potential in Turkey to the reconstruction of the electricity structure in Turkey is also investigated. Then, among the 25 hydrological basins in Turkey, the Eastern Black Sea Basin located in the northeast of Turkey, which has great advantages from the view point of small hydropower potential or hydropower potential without storage, is chosen as the case study to carry out some investigations concerning its potential and to analyze the contribution of the private sector (the corporate body) in regard to the development of hydro potential in this basin within the scope of the 4628 Electricity Market Law. With this law, concerning the restructuring of the electricity market, private sector investments in this segment have increased. In total, 1524 hydroelectric power projects with 22 360 MW installed capacity has been implemented until January 22nd, 2009 and this figure is continuously rising.
AtıfScopus31WoS27OpenAlex36İncele - BildiriYalnız künye2011Operational modal testing of an arch type steel highway bridge using SSI technique
Altunişik, A.C.; Bayraktar, A.; Sevim, B.
The paper determines the dynamic characteristics of an arch type steel highway bridge applying ambient vibration testing. A modern steel highway bridge which has arch type structural system with 216m total length and located in the Ayvacik county of Samsun, Turkey is selected as an application. Because of the fact that the bridge connects the villages which are separated with Suat Ugurlu Dam Lake, it has a major logistical importance for this region. The construction of the bridge completed in 2009 and opened the traffic. The experimental meas-urements are carried out by ambient vibration tests under traffic loads. Vibration data are gath-ered from the bridge deck. Measurement time, frequency span and effective mode number are determined considering similar studies in the literature and initial finite element analysis re-sults. Stochastic Subspace Identification technique (SSI) in the time domain are used for the output only modal identification and dynamic characteristics such as natural frequencies, mode shapes and damping ratios are determined, experimentally.
- BildiriYalnız künye2012Scopus SJRQ3Acetohydrazide derivative for selective separation and preconcentration of Cu(II) ions by coprecipitation method without using a carrier element
Ozdes, Duygu; Duran, Celal; Bektaş, Hakan; Tufekci, Mehmet; Soylak, Mustafa
A simple and rapid procedure based on the combination of carrier element free coprecipitation (CEFC) and flame atomic absorption spectrometric (FAAS) determinations has been developed for selective separation and preconcentration of Cu(II) ions in some environmental solid (Turkish and import coffee) and liquid (sea and stream waters) samples. In this method, acetohydrazide derivative was used as an organic coprecipitant without adding any carrier element for coprecipitation of Cu(II) ions. The preconcentration factor was found to be 50, the limit of detection (LOD) was 0.31 μgL -1, while the relative standard deviation (RSD) was found to be 1.6% for Cu(II) ions.
AtıfScopus15WoS15OpenAlex11İncele - MakaleAçık Erişim2013Scopus SJRQ2Detection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkey
ÇIÇek, Ayşegül Çopur; Düzgün, Azer Özad; Saral, Ayşegül; Kayman, Tuba; ÇIzmecI, Zeynep; Balci, Pervin Özlem; Dal, Tuba; Firat, Mehmet; Tosun, Ismail; Alitntop, Yasemin Ay
Objective: To investigate the antibiotic resistance genes inserted into class 1 and class 2 integrons in Acinetobacter baumannii (A. baumannii) isolates obtained from nine different cities in Turkey. Methods: A collection of 281 A. baumannii clinical isolates were collected from nine diferent state hospitals in Turkey and were confirmed as A. baumannii by conventional biochemical, API testing and bla-OXA-51 specific PCR. The isolates were examined by PCR for existence of class 1 and 2 integron gene cassettes. Results: They were characterized by antimicrobial susceptibility testing and the highest resistance rates were determined for piperacillin (90.03%), ciprofloxacin (87.54%), cefepime and trimethoprim/sulfamethoxazole (81.13%). The lowest resistance rates was for cefotaxime (3.55%). class I integrons were detected in 6.4% (18/281) of A. baumannii strains and no class 2 integron was detected. The gene cassettes of class 1 integrons AacC1-AAC(3) I-aadA1, AacC1-aadA1, AAC(3)-I, AAC(3)-I -AAC(3)-I -aadA1, TEM-1, AAC(3)-I-aadA1 - AAC(3)-I -AAC(3)-I, AAC(3)-I -AAC(3)-I -AAC(3)-I -aadA1, AAC(3)-I - aadA1, AAC(3)-I-AAC(3)-I, AAC(3)-I-aadA1-AAC(3)-I-aadA1, AAC(3)-I-AAC(3)-I-aadA1-AAC(3)-I-aadA1 were detected in eighteen strains. The aac genes family were most frequently found integrated into the class 1 integrons and it was followed by aadA genes and TEM-1 genes. Conclusions: This is an extensive study on the distribution of class 1 integron among A. baumannii in Turkey. In addition to these, two new alleles were observed. Their percentage rates of similarity to other cassettes are 95% aadA1 (TKA18) and 89% aadA1 (ANKA3).
AtıfScopus25OpenAlex24İncele - MakaleAçık Erişim2012Scopus SJRQ1Probabilistic sensitivity analysis of two suspension bridges in Istanbul, Turkey to near- and far-fault ground motion
Çavdar, Ö.
The aim of this paper is to compare the near-fault and far-fault ground motion effects on the probabilistic sensitivity dynamic responses of two suspension bridges in Istanbul. Two different types of suspension bridges are selected to investigate the near-fault (NF) and far-fault (FF) ground motion effects on the bridge sensitivity responses. NF and FF strong ground motion records, which have approximately identical peak ground accelerations, of the Kocaeli (1999) earthquake are selected for the analyses. Displacements and internal forces are determined using the probabilistic sensitivity method (PSM), which is one type of stochastic finite element method. The efficiency and accuracy of the proposed algorithm are validated by comparison with results of the Monte Carlo Simulation (MCS) method. The displacements and internal forces obtained from the analyses of suspension bridges subjected to each fault effect are compared with each other. It is clearly seen that there is more seismic demand on displacements and internal forces when suspension bridges are subjected to NF and FF ground motion.
AtıfScopus8WoS6OpenAlex6İncele - MakaleAçık Erişim2012Scopus SJRQ3Optimization of a new cloud point extraction procedure for the selective determination of trace amounts of total iron in some environmental samples
Duran, Celal; Özdeş, Duygu; Çelenk Kaya, Elif; Kantekin, Halit; Bulut, Volkan Numan; Tüfekçi, Mehmet
A new, simple, and rapid cloud point extraction (CPE) procedure system, combined with flame atomic absorption spectrometry (FAAS), was developed for selective separation, preconcentration, and determination of trace amounts of total iron in some environmental samples. The complexing agent, N,N-(2,2 - (ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(2-chloroacetamide) (EDBOCA), is selective at pH 5.0 for only Fe(II) and Fe(III) ions in the presence of Cu(II), Pb(II), Cd(II), Mn(II), Co(II), Cr(III), Cr(VI), Ni(II), Zn(II), Al(III), Mo(VI), Pd(II), Pt(IV), Au(III), and V(V) ions. The procedure is based on the complexation of Fe(III) ions with EDBOCA reagent in the presence of Triton X-114 (TX-114) as a non-ionic surfactant. The optimum conditions for the CPE of Fe(III) ions were investigated with respect to several experimental parameters such as pH of the solution, TX-114 and EDBOCA concentrations, incubation time and temperature, and centrifugation rate and time. The detection limit for Fe(III) ions based on the 3 times the standard deviation of the blanks (N:10) was found to be 1.22 μg L ?1 , while the relative standard deviation (RSD) was 4.2%. Environment Canada TM-25.3 and CRM-SA-C Sandy Soil C, as certified reference materials, were used, and spike tests were applied to validate the method. The method was applied to some real environmental samples to evaluate their total iron levels.
AtıfScopus22WoS18OpenAlex13TR Dizin1
İncele - MakaleYalnız künye2014Scopus SJRQ1Separation and preconcentration of lead, chromium and copper by using with the combination coprecipitation-flame atomic absorption spectrometric determination
Bahadır, Zekeriyya; Bulut, Volkan Numan; Ozdes, Duygu; Duran, Celal; Bektas, Hakan; Soylak, Mustafa
A coprecipitation method was developed for the quantitative separation and preconcentration of Pb(II), Cr(III) and Cu(II) ions. Analytes were coprecipitated using a triazole derivative (2-{4-[2-(1H-indol-3-yl)ethyl]-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}. N-aryl methylidene acetohydrazid). The analytes were analyzed by flame atomic absorption spectrometry. The parameters such as sample pH, amount of reagent, sample volume, matrix effects etc. were investigated. The enrichment factor for the analyzed metal ions was obtained as 50. The relative standard deviations (RSD) were in the range of 2.8-4.1%. The accuracy of the proposed procedure was checked by the analysis of the CRM-C-Sandy Soil C. The method was successfully applied to real samples.
AtıfScopus73WoS66OpenAlex65İncele - MakaleYalnız künye2012Scopus SJRQ2The importance of multifocal/multicentric tumor on the disease-free survival of breast cancer patients: Single center experience
Ustaalioglu, Basak Oven; Bilici, Ahmet; Kefeli, Umut; Şeker, Mesut; Oncel, Mustafa; Gezen, Cem; Gumus, Mahmut; Demirelli, Fuat
OBJECTIVES:: Multifocal/multicentric breast cancers have been comprehensively studied and their outcomes have been compared with unifocal tumors. We evaluated the impact of multifocality and multicentricity on the disease-free survival (DFS) and overall survival of breast cancer patients and tried to analyze the correlation between multifocality/multicentricity (M/M) and other prognostic factors. MATERIAL AND METHODS:: Between 1994 and 2009, we analyzed retrospectively 697 breast cancer patients. Multicentric and multifocal breast cancer were defined as the presence of 2 or more invasive tumor foci within the different quadrants of the same breast or within a same quadrant of the breast, respectively. M/M and other prognostic factors were evaluated using univariate and multivariate analyses. RESULTS:: Multifocal/multicentric tumors were seen in 107 (15.4%) of the 697 breast cancer patients. pT and pN stage were related with the presence of multifocal/multicentric tumors. As tumor size increased and the number of axillary lymph nodes metastasis increased, the incidence of M/M increased significantly (P=0.003 vs. P=0.02, respectively). Overall, the median DFS time of patients with multifocal/multicentric tumors was significantly worse than that of the unifocal tumors (55 vs. 137 mo, P<0.001). Multivariate analysis showed that the presence of M/M was the most important prognostic factor for DFS (P=0.001, hazard ratio (HR): 0.33; 95% confidence interval (CI), 0.18-0.58), as were pN stage and extracapsular extension of the tumor (P=0.01, HR: 1.74; 95% CI, 1.13-2.69) (P=0.03, HR: 1.9; 95% CI, 1.04-3.47, respectively). M/M were not also statistically significant prognostic factors in breast cancer for overall survival (P=0.06). CONCLUSIONS:: M/M imparts an unfavorable prognosis on the DFS of breast cancer patients in comparison to unifocal tumors and the presence of multifocal/multicentric tumors were associated with advanced pT and pN stages.
AtıfScopus36WoS35OpenAlex41İncele - MakaleAçık Erişim2010Effect of rectangular/circular cutouts on thermal buckling load optimization of angle-ply laminated thin plates
Topal, Umut; Uzman, Ümit
This paper deals with thermal buckling load optimization of symmetrically laminated angle-ply thin plates with centrally located different cutouts subjected to a uniform temperature load rise. The optimum results are given for maximum buckling temperature and the fibre orientation is adopted as design variable. The results are obtained for the various cutout geometries such as rectangle and circle. The modified feasible direction (MFD) method is used for the optimization routine. Therefore a program based on FORTRAN is used. Finally, the effects of cutout areas, plate aspect ratios and boundary conditions on the optimum results are demonstrated.
AtıfScopus6WoS4OpenAlex5İncele - MakaleYalnız künye2015Scopus SJRQ2eNOS and iNOS trigger apoptosis in the brains of sheep and goats naturally infected with the border disease virus
Dincel, Gungor Cagdas; Kul, Oguz
In this study, apoptotic and anti-apoptotic mechanisms and if present, which pathway to trigger the apoptosis in the brains of Border Disease Virus (BDV) infected lambs (n=10) and goat kids (n=5) were investigated. Briefly, apoptotic (caspase 3, caspase 9) and anti-apoptotic markers (Bcl-2), cytokine response (TNF-α, INF-γ), reactive gliosis and myelin loss were examined. eNOS, iNOS, caspase 9, caspase 3 and GFAP expressions were higher in BDV infected tissues compared to control animals (6 kids and 6 lambs) (p<0.05). Double immunoperoxidase test revelaed that TUNEL positive apoptotic cells showed significant association with increased eNOS-iNOS and iNOS-BDV expressions. However, no significant differences were found for TNFR1, TNF-α and INF-γ expressions in BD (p>0.05). There was a positive correlation between the intensity of myelin loss, GFAP activity and severity of infection. Inconclusion, as a novel finding, it is established that eNOS and iNOS overexpressions are coassociated with apoptosis in BDV infected neurons and neuroglia. The results also strongly suggested that BDV infected apoptotic cells mainly prefer the intrinsic pathway that might be most likely related to increased nitric oxide levels.
AtıfScopus16WoS13OpenAlex13İncele
