Yayınlar
Koleksiyondaki öğeler
- MakaleAçık Erişim2024Scopus SJRQ1The Association Between Glycemic Variability and Mortality in Critically Ill Patients: A Multicenter Prospective Observational Study
Emgin, Omer; Yavuz, Mehmet; Sahin, Adem; Günes, Murat; Eser, Mustafa; Yavuz, Tunzala; Kökalan, Damla; Ergün, Bisar; Rollas, Kazim; Çakirgöz, Mensure Yilmaz
Background: Glycemic variability (GV) is a prevalent and significant condition observed in critically ill patients. This study aimed to investigate the relationship between early glycemic variability parameters and 28-day mortality in critically ill patients. Methods: A multicenter, prospective, and observational study was performed at five tertiary intensive care units (ICUs) in Turkey. All patients who had more than six blood glucose level (BGL) measures per 24 h were included. The parameters of GV including the SD, MGL, MGD (the difference between the maximal and minimal glucose level), and the CV (the percentage of SD to the MGL) in the first 24 h were recorded. Results: A total of 578 eligible patients were enrolled in the study, of whom 43.6% were women. The mean age of the patients was 68.09 +/- 16.62 years. Overall mortality was 31.5% (n = 182). The glycemic parameters of the CV, SD, and MGD were significantly higher in the non-survivor group than in the survivor group (p = 0.040, 0.006, and 0.002, respectively). The multivariate logistic regression analysis revealed that the CV (OR 1.023; 95% CI 1.004-1.042; p = 0.017) was an independent factor that increased mortality. Spearman's rho correlation analysis revealed a strong (r:0.871) and statistically significant correlation (p < 0.001) between the CV and MGD. Conclusions: The CV calculated within the first 24 h of ICU admission is independently associated with 28-day mortality. The MGD is correlated with the CV and is maybe a practical tool to predict increased risk of mortality at the bedside. However, further studies are needed to establish the independent association of the MGD with mortality.
AtıfWoS13OpenAlex11
İncele - BildiriYalnız künye2016Scopus SJRQ1The epithelizan effect of the Morus nigra extracts on rats
Kilinç, K.; Turan, I.; Özgen, U.; Livaoglu, M.; Ural, A.; Sener, S. O.; Kara, H.; Efe, G.; Demir, S.
- MakaleAçık Erişim201017,18-Dibromo-8-methyl-4,12-ditosyl-3,4,5,6,7,8,9,10,11,12,13,14-dodecahydro-2H-benzo[b][1,4,7,11,15]dioxatriazacycloheptadecine
Kelesoglu, Zeynep; Kaya, Elif Celenk; Kantekin, Halit; Bueyuekguengoer, Orhan
In the title compound, C31H39Br2N3O6S2, a 17-membered aza-macrocyclic ligand containing two ether O and three aza N atoms, the three pendant aromatic rings form an 'E' shape. The dihedral angles between the central benzene ring and the side ones are 17.8 (3) and 7.4 (3)degrees , and the dihedral angle between the tosyl rings is 10.6 (3)degrees . The methyl group is disordered over two orientations, with occupancies of 0.52 (15) and 0.48 (15).
AtıfOpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ2Measuring Dysfunctional Grief due to a COVID-19 Loss: A Kurdish Validation Study of the Pandemic Grief Scale
Karimi, Kambiz; Yaghoobi, Abolghasem; Gungor, Sunay; Karimi, Afagh; Sohrabi, Saeed
Millions of people are grieving the loss of someone who died of COVID-19. The current study aims to validate a Kurdish version of the Pandemic Grief Scale which is a brief English-language mental health screener to identify cases of dysfunctional grief associated with a COVID-19 death. We recruited 501 participants. Participants completed the PGS, WSAS, PHQ-9, and Optimism scales. The factor structure, reliability, and validity of the PGS were analyzed. Using exploratory factor analysis (N1 = 300), we derived an one-factor structure. In confirmatory factor analysis (N2 = 201), the one-factor model showed good to excellent fitness. The PGS was positively correlated with PHQ-4, and WSAS and negatively correlated with optimism. The scale was internally consistent with a Cronbach's alpha of .79. These results support that the Kurdish version of the PGS is a valid and reliable assessment to assess the severity of dysfunctional grief associated with a COVID-19 death.
- MakaleAçık Erişim2024A NEW LOGARITHMIC TYPE ESTIMATORS FOR ANALYSIS OF NUMBER OF AFTERSHOCKS USING POISSON DISTRIBUTION
Zaman, Tolga; Iftikhar, Soofia; Sozen, Caglar; Sharma, Prayas
Earthquake is a fierce and unavoidable natural disaster. The study of aftershocks following an earthquake provides a comprehensive understanding of seismic activity, making it an important area of research. Although it is important to mention that the use of the Poisson distributed population, to estimate the mass mean of rare events such as earthquakes, has been little studied in the literature. In this context, this study proposes a new class of logarithmic type ratio estimators for estimating the mean of a Poisson distributed population in a simple random sampling without replacement. The proposed estimators are obtained using the logarithmic transformation of the ratio estimator, and the expressions for the mean square error (MSE) are also derived to the first order of approximation. The study demonstrates that the proposed logarithmic type estimators are more efficient than the existing estimators, both theoretically and empirically. The Empirical evidence from a real data study conducted using earthquake data from Turkey confirms the superiority of the proposed estimators over the existing estimators. The study provides valuable insights for researchers and practitioners working with Poisson distributed populations and requiring ratio estimators using simple random sampling without replacement.
AtıfWoS6OpenAlex4İncele - MakaleYalnız künye2026Scopus SJRQ2Contralateral DTI-ALPS index as a prognostic biomarker in IDH-wildtype glioblastoma: integrating extent of resection and sex-stratified analyses
Aygün, Tayfun; Keskin, Arif; Palanci, Ozgur; Öztanir, Mustafa Namik; Yücel, Nurullah; Hekimoglu, Gulam
Aim This study aimed to evaluate the independent prognostic value of the contralateral DTI-ALPS index in IDH-wildtype glioblastoma, incorporating tumor morphometry, extent of resection, and sex-stratified analyses within a multivariable framework.Methods A retrospective analysis was performed on 153 IDH-wildtype glioblastoma patients from the publicly available UPENN-GBM dataset. Contralateral DTI-ALPS was calculated using DSI Studio via manual ROI placement; tumor morphometry was derived from expert-annotated segmentation labels using 3D Slicer. Survival analyses included Kaplan-Meier estimation, multivariable Cox regression, time-dependent ROC, restricted cubic spline, and sequential C-index comparison with likelihood-ratio testing.Results The contralateral DTI-ALPS index independently predicted overall survival after adjustment for age, sex, tumor volume, and GTR status (HR = 0.405, 95% CI: 0.227-0.725, p = 0.002). Each one standard deviation increase in DTI-ALPS was associated with a 24.2% reduction in mortality risk. GTR >= 90% (HR = 0.651, p = 0.017) and age (HR = 1.021, p = 0.007) also retained independent significance. DTI-ALPS significantly improved model discrimination beyond age alone (C-index: 0.625 -> 0.653 -> 0.668; likelihood-ratio test p = 0.002). Time-dependent AUC reached 0.741 at 6 months. ALPS-based stratification was more pronounced in the subtotal resection subgroup. Sex-stratified analyses showed numerically stronger associations in females, but formal interaction testing did not confirm effect modification. In an exploratory MGMT subset (n = 57), DTI-ALPS did not retain independent significance after MGMT adjustment.Conclusion The contralateral DTI-ALPS index may provide complementary prognostic information beyond established clinical predictors in IDH-wildtype glioblastoma; however, given the incomplete MGMT methylation data and ongoing methodological debate regarding the biological validity of DTI-ALPS, these findings should be considered exploratory. Prospective validation in cohorts with complete molecular and treatment data is required.
- BildiriYalnız künye2013Scopus SJRQ1Relationship Between Platelet Indices and International Normalized Ratio In Patients With Non-Valvular Atrial Fibrillation
Arik, Osman Ziya; Özkan, Bugra; Kutlu, Rasim; Karal, Huseyin; Memetoglu, Mehmet Erdem; Sahin, Durmus Yildiray; Tekin, Kamuran; Kaypakli, Onur; Uçak, Haci Ali; Çayli, Murat
- MakaleAçık Erişim2020Effect of filler percentage of recycled asphalt pavement (RAP) materials on CBR performance and cost analysis
Seferoglu, Aysegul Gunes; Seferoglu, Mehmet Tevfik; Akpinar, Muhammet Vefa; Çelik, Muhammet
Recycled asphalt pavement (RAP) materials are an alternative to natural aggregate (NA) because they reduce environmental pollution and provide energy and cost savings. In many countries abroad, the usage of RAP materials in road pavement layers are permissible at certain rates. However, the mechanical properties of RAP materials are dependent on; the materials are derived from the in which pavement layer, the service life and construction characteristics of the road it is milled, the properties of the materials used (bitumen and aggregate) in the layer and the characteristics of the milling machine. In this study, two types of RAP materials (RAP(1) and RAP(2)) obtained from the degraded wearing layers of two different roadway using milling machine were mixed with NA in different rates (0%, 15%, 30%, 45%, 60%, 100%). Some of the characteristics of the mixtures were examined with reference to 100% NA mixture values by performing laboratory tests such as bitumen ratio, sieve analysis, modified proctor and California bearing ratio (CBR) on the mixtures obtained. According to the results, maximum rates of RAP(1) and RAP(2) which can be used in plant-mix base type-1 layer as an alternative material to NA is determined according to Turkey Highway Technical Specification. In addition, in the case of using RAP materials, the profit rates of material costs to be reduced by the reduction of the need for NA material are also determined by cost analysis.
- MakaleAçık Erişim2020Can Zeolite Application Decrease the Need for Nitrogen in Silage Corn?
Gül, Zeynep; Tang, Mustafa; Yolcu, Halil
The effects of applications of zeolite, nitrogen and zeolite + nitrogen on yield, quality and some morphological traits of silage corn was researched at the Research Station of the Agriculture Faculty, University of Ataturk, Eastern Turkey, during 2012 and 2013. Treatments included a control, three zeolite (Z(1): 500, Z(2): 1000, Z(3): 1500 kg ha(-1)), three nitrogen (N-1: 50, N-2: 100, N-3: 150 kg ha(-1)) and nine combinations of zeolite + nitrogen. The experimental design was randomized complete blocks with three replications. The application of zeolite + nitrogen application enhanced silage yield by 5.8-18.9%, dry matter yield by 4.5-21.4%, corncob rate by 6.6%, plant height by 3.0-16.1% and leaf rate by 17.5%. Further, the application of zeolite + medium or low nitrogen application produced similar silage yield, dry matter yield, dry matter rate, crude protein content, ADF, NDF, corncob rate, stem rate, plant height and leaf rate in comparison to the highest level nitrogen application. The results indicate that the application of zeolite + nitrogen can be used to increase efficiency of nitrogen and to decrease nitrogen requirements in silage corn for yield and other parameters.
- BildiriYalnız künye2011Scopus SJRQ2PERCUTANEOUS TREATMENT OF A GIANT ILIAC ARTERY PSEUDOANEURYSM IN BEHCET'S DISEASE
Memetoglu, M. E.; Kalkan, A.; Tas, M.; Kacar, E.
- MakaleAçık Erişim2020Bladder Sparing Surgical Treatment in a Patient with Pelvic Lipomatosis
Tarhan, Fatih; Kayukoglu, Ovunc; Can, Utku; Özgül, Aydin
Pelvic lipomatosis is an uncommon benign disease characterized by the excessive growth of mature fat tissue in the perivesical and perirectal areas. A 61-year-old male patient, who was admitted with voiding difficulty, underwent bladder-sparing surgery with excision of adipose tissue for pelvic lipomatosis. The case is presented and discussed with the relevant literature.
- MakaleAçık Erişim2024Physicochemical, sensory and antimicrobial properties of the ice cream containing lavender (Lavandula angustifolia) essential oil
Ürkek, Bayram; Aktas, Haktan; Öztug, Mirac Ozer; Yeniçeri, Esra; Öztug, Pinar
In this study, lavender essential oil (LEO) was added to ice creams as ingredient at 0, 0.02, 0.05 and 0.1% ratios. Some physicochemical, viscosity, rheological, colorimetric, sensory properties, and pathogen inhibition, including L. monocytogenes ATCC 7644 and S. aureus ATCC 29213, of the ice cream samples with the LEO were investigated. It was determined that the melting rate of the ice creams with the LEO was lower (P<0.05) and the overrun values were higher (P<0.05) than the control sample. The highest L* and a* values were determined in the control samples and the sample with 0.1% LEO, respectively. While C* value of the sample with 0.02% LEO was higher than the other samples (P<0.05), the highest white index (WI) value was determined in the control and the sample with 0.01% LEO. The sample containing 0.01% LEO had the highest viscosity values at 20 and 50 rpm. It was determined that there was no statistically significant difference in the consistency coefficients of the samples (P>0.05) and all samples had pseudolplastic flow. The control sample had the highest sensory score, followed by the sample with 0.02% LEO. It was determined that the LEO addition only had a decreasing effect on the count of S. aureus ATCC 29213.
AtıfWoS2OpenAlex5İncele - BildiriAçık Erişim2013Scopus SJRQ1In Coronary Artery Disease Comparison of Turkey and Europe According to Kyrgyzstan and Euroaspire III Results
Kutlu, Rasim; Memetoglu, Mehmet Erdem; Muratalievic, Tolkun Murataliev
- MakaleYalnız künye2020Economic Analysis of the Use of Reclaimed Asphalt Pavement (RAP) Materials in Plant-Mix Base Courses
Seferoglu, Aysegul Gunes; Seferoglu, Mehmet Tevfik; Akpinar, Muhammet Vefa; Çelik, Muhammet
The aim of this study is to determine the financial benefits to be gained based on the percentages of reclaimed asphalt pavement (RAP) material suitable for use in plent-mix courses (PBCs) to be designed according to the specification of Turkey Department of Transportation. Cost analysis of all RAP mixtures were made considering the construction of the plant-mix base course and the transportation costs of the materials, it was researched that the use of RAP would be an economical application in terms of how far the RAP material was taken. As a result of the study, it has been determined that the use of 100% RAP material in PBC is possible with cement reinforcement and it provides a profit of more than 16% in terms of costs in case of using virgin aggregate (VA) instead. RAP material is an alternative to virgin aggregate and is a more economical material in terms of cost.
AtıfWoS1İncele - BildiriYalnız künye2011Scopus SJRQ2MANAGEMENT OF DEEP VEIN THROMBOSIS IN EVLT
Memetoglu, M. E.; Kalkan, A.; Kurtcan, S.; Kara, V.; Ertas, G.; Cetinkaya, A. S.; Talay, S.
- MakaleAçık Erişim2020The Healing Effect of Resveratrol on Ischemic Tissue Injury in an Experimental Carbon Monoxide Poisoning Model
Sahin, Aynur; Pasli, Sinan; Cicek, Mustafa; Karahan, Suleyman Caner; Mentese, Ahmet; Yulug, Esin; Karaca, Yunus; Tatli, Ozgur
Purpose: To investigate the healing effect of resveratrol on ischemia, inflammation and oxidative injury in brain and heart tissue of rats in an experimentally induced carbonmonoxide (CO) intoxication model. Methods: Twenty-eight mature female Spraque Dawley rats were randomized into four groups of seven animals each. Groups I and II inhaled room air for 60 minutes. Groups III and IV inhaled a high concentration of a 5000 ppm CO gas mixture at 4 L/min until loss of consciousness. Blood CO levels were measured from 1 mL blood specimens collected from the tail vein. Groups I and III received 1 mL of normal saline while groups II and IV received 25 mg/kg resveratrol intraperitoneally. At the end of 48 hour, the rats were sacrified and later blood, brain and heart tissue samples were taken for histopathological and biochemical evaluation. Neuron damage scores, percentages of degenerate neurons and apoptosis rates in the cortex and hypothalamus were calculated in brain tissues. Myocyte degeneration, vascular congestion and myocyte apoptosis rates were calculated in heart tissues. Total antioxidant (TAS), total oxidant (TOS) and oxidative stress index (OSI) levels were also calculated from the tissue samples. Results: Histopathological evaluation revealed that resveratrol significantly reduced tissue damage in the brain when groups III and IV were compared (p<0.05). Resveratrol also reduced cardiac myocyte degeneration and myocyte apoptosis rate in heart tissue (p=0.004 and p=0.002). No positive effect was determined at analysis of antioxidant parameters. Conclusion: The results of this study investigated that resveratrol administration in experimental setting may be beneficial in healing injury secondary to CO intoxication in brain and heart tissue.
AtıfWoS2OpenAlex2İncele - MakaleYalnız künye2013Scopus SJRQ3A rare cause of acute respiratory failure: spontaneous pneumomediastinum due to cocaine use
Memetoglu, Mehmet Erdem; Kalkan, Asim; Tutar, Nuri; Kurtcan, Serpil; Gündüz, Abdulkadir
Spontaneous pneumomediastinum is defined as free air in mediastinum without any underlying pulmonary pathology. Although spontaneous pneumomediastinum is a rarely seen clinical entity, it is one of the most common reasons of sudden pleuritic chest pain in healthy young individuals. Cocaine inhalation is also associated with the development of spontaneous pneumomediastinum. Our case having spontaneous pneumomediastinum was referred to our emergency service with the complaint of acute respiratory failure due to cocaine abuse, and the etiology, clinical presentation and the treatment of the disease were evaluated in our study.
AtıfWoS2OpenAlex4İncele - BildiriAçık Erişim2017The Relationship between Types of Bullying experienced by Primary School Students and Their Anxiety, State-Trait, Self-Esteem And Certain Socio-Demographic Characteristics
Demirbag, Birsel Canan; Çiçek, Zeynep; Yigitbas, Cagla; Özkan, Cigdem Gamze; Dinçer, Ahmet
Bullying experienced by children causes negative emotions which lead to failure in their lives. This study aims to determine the relationship between types of bullying and anxiety, state-trait, self-esteem and certain socio-demographic characteristics of primary school students who exposed to bullying at least two times. A primary school in the city center of eastern part of Turkey was selected by simple random sampling method. A socio-demographic questionnaire, which was developed by the researchers, and state-trait anxiety inventory and self-esteem scales were provided to 595 students in this school by explaining how to fill out the questionnaires between January 1 and January 31, 2015. The most common types of bullying expressed by children were kicking and slapping in the physical bullying 11.7%, kidding in the verbal bullying 14.1%, discrimination in the emotional bullying 7.3% and sexually explicit expressions in the sexual bullying type 4.2%. (C) 2017 The Authors. Published by Elsevier Ltd.
AtıfWoS5OpenAlex12İncele - MakaleAçık Erişim2021Evaluation of Cytotoxic Effect of Onosma armeniacum Extract on Various Cancer Cells
Demir, Selim; Ayazoglu Demir, Elif; Turan, Ibrahim; Özgen, Ufuk
The aim of this study was to investigate the antioxidant properties of the root extract of Onosma armeniacum and its cytotoxic effect against human liver (HepG2), lung (A549) and colon (WiDr) cancer cell lines compared with a normal fibroblast cell line. Antioxidant properties of the extract was determined using the colorimetric methods. The cytotoxic effect of the extract were investigated using MTT assay. The total phenolic content and reducing power values of extract were 26.1 +/- 0.4 mg gallic acid equivalent and 52.6 +/- 1.1 mg trolox equivalent per g sample, respectively. The extract exhibited selective cytotoxic effect in all studied cancer cell lines, especially HepG2 (3.6-fold). The results of this study reveal that O. armeniacum, which has been found to have acceptable antioxidant and cytotoxic effects, should be examined with more comprehensive studies.
AtıfWoS8OpenAlex12TR Dizin1
İncele - MakaleAçık Erişim2021Men's Choice of Contraception Method
Ozcan, Handan; Yigitbas, Cagla; Karaca, Mucahit Talha
Objective: The aim of this study is to examine the contraception choices of men, aged between 18-60 and living in the center of a province in the Gumushane. Methods: The study is of a descriptive type. As a data collection form, an Individual Information Form consisting of a total of 32 questions was used. This form questions the demographic-physical-biological-social-health histories of the participants and their knowledge, attitudes, behaviors about contraception methods. Averages were given together with standard deviations. Results: 20.8 % of the participants are aged between 26-33. It was seen that 25.3% of the participants had knowledge about contraception methods and 64.7% did not use any methods. When the variables of the age and the marital status are approached in terms of having sufficient knowledge about contraception and still using contraception methods, there is a statistical significance between the variable of 'is the use of contraception methods harmful to health?' with the status of still using contraception methods. A statistical significance is also found between the variable of being sexually active with the status of having sufficient knowledge about contraception and still using contraception methods (p<0.05). Conclusion: In this study, It has been determined that men who had sufficient information about contraceptions had higher age and higher education levels, were sexually active and married. It has been seen that the age, the marital status, the perception of contraception as harmful to health, the status of being sexually active did not affect receiving any training about contraception.
