Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Abdullah Yılmaz, Mustafa(1)
- Bayrakdaroglu, Serdar(1)
- Behçet, Lutfi(1)
- Cakir, Oguz(1)
- Ceylan, Halil Ibrahim(1)
- Cherappurath, Nafih(1)
- Elayaraja, Masilamani(1)
- Gülçin, Ilhami(1)
- Ilyasoǧlu, Huri(1)
- Izol, Ebubekir(1)
- Kabeer, Dilshith A.(1)
- Kayaoglu, Esma(1)
- Mavritsakis, Nikolaos(1)
- Muharrem Ural(1)
- Muntean, Raul Ioan(1)
- Navaf, Muhammed(1)
- Necip, Adem(1)
- Perumbalath, Shamshadali(1)
- Satheesan, Saranya T.(1)
- Sunooj, Kappat Valiyapeediyekkal(1)
- Thoompenthodi, Muhammed Ali(1)
- Turhan, Münire(1)
- Yapici, Ismail(1)
- Yapıcı, İsmail(1)
- Yilmaz, Mustafa Abdullah(1)
- Zengin, Gökhan(1)
- İzol, Ebubekir(1)
Yayınlar
- MakaleYalnız künye2025Scopus SJRQ2Phytochemical Profile, Antioxidant Capacity, Acetylcholinesterase, and Butyrylcholinesterase Enzyme Inhibition Properties of Myosotis amoena Boiss
Yapici, Ismail; Kayaoglu, Esma; Izol, Ebubekir; Yilmaz, Mustafa Abdullah; Behçet, Lutfi; Cakir, Oguz; Gülçin, Ilhami
Myosotis amoena Boiss. (Turkish name: Ho & scedil; boncukotu) is a perennial herbaceous plant that produces blue flowers during the spring. Phytochemicals, which are secondary metabolites distributed across plants, fungi, microorganisms, and even animal tissues, play crucial roles in health through their antioxidant and bioactive properties. Their antioxidant capacity largely arises from hydroxyl groups and aromatic ring structures that stabilize free radicals via electron delocalization. Enzyme inhibition is a therapeutic strategy in several diseases, including Alzheimer's disease (AD), where acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors are employed to manage symptoms. This study investigated the phytochemical composition (via LC-MS/MS), total phenolic content, antioxidant capacity, and AChE/BChE inhibitory effects of the ethanol extract of M. amoena using four in vitro methods. The CUPRAC assay demonstrated that M. amoena (1.070) exhibited higher antioxidant activity than Trolox (0.894), although its activity in FRAP, ABTS, and Fe3+ reduction assays was lower compared to standard antioxidants. The extract contained 53.03 mg GAE/g extract of total phenolics, with rosmarinic acid being the predominant compound (15.27 mg/g). Furthermore, the extract strongly inhibited AChE and BChE, with IC50 values of 3.9 and 19.8 mu g/mL, respectively. These findings highlight, for the first time, the significant bioactive potential of M. amoena as a natural source of antioxidants and cholinesterase inhibitors, supporting its prospective use in the prevention or management of neurodegenerative conditions.
AtıfWoS4OpenAlex8
İncele - MakaleAçık Erişim2025Scopus SJRQ2Research of Peganum harmala: Phytochemical Content, Mineral Profile, Antioxidant, Antidiabetic, Anticholinergic Properties, and Molecular Docking
İzol, Ebubekir; Turhan, Münire; Yapıcı, İsmail; Necip, Adem; Abdullah Yılmaz, Mustafa; Zengin, Gökhan
Peganum harmala is a significant medicinal, aromatic plant used in traditional medicine and the subject of many studies. In this study, the phytochemical compound and mineral profile of the plant's ethanol extract were identified quantitatively. Antioxidant properties were determined by total phenolic and flavonoid content, FRAP, DPPH, CUPRAC, ABTS, metal chelating, and phosphomolybdenum assays. Antidiabetic, anticholinergic, and skin care properties were specified by the inhibition of tyrosinase, α-glucosidase, α-amylase, butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) enzymes, respectively. In addition, binding interactions of major phytochemicals with all enzymes were investigated by molecular docking studies. The phytochemical compound of the extract contained significant bioactive components such as acacetin, gentisic acid, p-coumaric acid, quinic acid, rutin, apigenin, and chrysin, while the mineral profile was rich in salt elements. AChE, BChE, tyrosinase, α-amylase, and α-glycosidase enzyme inhibitor results were determined as 2.99 mg GALAE/g, 4.14 mg GALAE/g, 35.8 mg KAE/g, 2.76 mmol ACAE/g, and 1.20 mmol ACAE/g, respectively. As a result, it was identified that it had antioxidant properties and strongly inhibited all enzymes except tyrosinase. The docking scores of major bioactive phytochemicals were found to be high. The best binding pose was obtained by docking acacetin into the active site of AChE (PDB: 4EY7), BChE (PDB: 4BDS), α-glucosidase (PDB: 3WY1), α-amylase (PDB: 6GXV) and tyrosinase (PDB: 2Y9X) receptors. Docking score values were calculated as −10.4, −9.2, −8.8, −7.8, and −7.4 kcal/mol, respectively. Thus, it was revealed that P. harmala has an important potential in drug research and treatment of some diseases.
AtıfScopus14WoS13OpenAlex18
İncele - Derleme MakaleAçık Erişim2025Scopus SJRQ1Synergistic Effects of Exercise and Nano-Curcumin Supplementation in Women with Lifestyle-Related Diseases: A Scoping Review
Cherappurath, Nafih; Navaf, Muhammed; Ceylan, Halil Ibrahim; Elayaraja, Masilamani; Sunooj, Kappat Valiyapeediyekkal; Satheesan, Saranya T.; Thoompenthodi, Muhammed Ali; Perumbalath, Shamshadali; Bayrakdaroglu, Serdar; Muntean, Raul Ioan
Background/Objectives: Lifestyle-related diseases such as obesity, diabetes, hypertension, metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), and osteoarthritis disproportionately affect women due to hormonal, metabolic, and socio-cultural factors. Emerging evidence suggests that combining structured exercise with nano-curcumin, a bioavailable phytochemical formulation with potent antioxidant and anti-inflammatory properties, may provide synergistic benefits. This scoping review systematically synthesizes available evidence on the combined effects of nano-curcumin supplementation and exercise interventions on health outcomes in women with lifestyle-related diseases. Methods: Following the Joanna Briggs Institute methodology and the PRISMA-ScR framework, a comprehensive database search was conducted in March 2025 and updated in June 2025. Records were retrieved from Scopus (n = 30), Web of Science (n = 22), PubMed (n = 18), and other sources (n = 71), yielding a total of 141 studies. After screening and deduplication, eight studies met the inclusion criteria and were included in this review. All the studies were conducted in Iran with small sample sizes (12-53 participants) and short intervention durations (6-16 weeks). Therefore, the current evidence is geographically and demographically limited. Results: Across the included trials, the combined interventions produced additive or synergistic improvements in oxidative stress markers, inflammatory cytokines, lipid and glucose metabolism, cardiovascular function, pulmonary capacity, muscle fitness, and psychological outcomes (e.g., depression). When paired with nano-curcumin supplementation at different concentrations, high-intensity interval training, aerobic exercise, Pilates, and resistance training consistently outperformed exercise or supplementation alone in modulating antioxidant defenses, reducing systemic inflammation, and improving metabolic risk factors. Conclusions: The integration of exercise and nano-curcumin supplementation appears to confer superior benefits for women with lifestyle-related diseases compared with either approach alone. These findings highlight the potential of combining phytochemicals with lifestyle interventions to optimize women's health outcomes. However, most available evidence originates from small, short-term studies in single geographic regions. Large-scale, multicenter, randomized controlled trials with diverse populations are warranted to establish standardized protocols and optimal dosing strategies, and to assess long-term safety and efficacy.
AtıfScopus2WoS2OpenAlex1İncele - Yüksek Lisans TeziAçık Erişim2022Yerli ve yabancı bazı kışlık ekmeklik buğday çeşitlerinin erken dönem kuraklık stresine katlanma bakımından değerlendirilmesi
Muharrem Ural
ÖZET Yapılan çalışmada, 10 yerli ve 10 yabancı olmak üzere, 20 kışlık ekmeklik buğday (Triticum aestivum L.) çeşidinin, erken dönemde meydana gelebilecek kuraklık stresine karşı morfo-fizyolojik ve fito-kimyasal özellikleri incelenmiştir. Bu anlamda, %100 tarla kapasitesinde ve %25 tarla kapasitesinde tutularak, laboratuvar ortamında sera koşulları oluşturulmuştur. Çalışmalar, uygulamalar (su stressiz kontrol ve su stresli kurak koşullar) ana parsellere ve çeşitler alt parsellere yerleştirilmek suretiyle, üç tekrarlamalı olarak tesadüf parsellerinde bölünmüş parseller deneme desenine göre yürütülmüştür. Çalışma kapsamında, yaprak en, boy ve en/boy oranı, yaprak klorofil-a, klorofil-b, toplam klorofil ve klorofil-a/b, kök yaş ağırlığı, taç yaş ağırlığı, kök/taç yaş ağırlıklar oranı, ELWR (kesilen yaprak su tutma kapasitesi), MTS (membran kararlılığı), ortam-yaprak sıcaklığı farkı (OYSF), yaprak kül içeriği, yaprak potasyum (K+) içeriği, karotenoid içeriği, prolin ve toplam fonolik bileşik içeriği gibi morfo-fizyolojik ve fito-kimyasal özellikler incelenmiştir. Ayrıca, uygulamaların ve çeşitlerin, çoğu özellikler bakımından; yine uygulama×çeşit interaksiyonlarının bakımından çoğu özelliklerin istatistiksel anlamda değişim gösterdiği belirlenmiştir. Yapılan analizler sonucunda; kuraklık stresi ile birlikte yaprak eni ve boyunda, klorofil-b ve klorofil a/b, kök ve taç yaş ağırlığında, MTS, OYSF, yaprak kül içeriği ve yaprak K+ içeriğinde azalmalar gözlenmiştir. Yaprak en/boy, klorofil-a, toplam klorofil, kök/taç oranı, ELWR, karotenoid, prolin ve toplam fenolik içeriğinde ise artış olduğu saptanmıştır. Sonuç olarak, denemede incelenen özellikler, erken dönemde yaşanabilecek kuraklık veya diğer abiyotik stres çalışmalarında, verime giden yolda birer morfo-fizyolojik ve fitokimyasal ıslah kriteri olarak kullanılmasının yanısıra; gerek genotip sayısı ve gerekse uygulama sayısının arttırılarak tarla denemeleri ve buna benzer sera denemelerinin birlikte yürütülmesi çalışmaların kesinliği ve sağlığı açısından daha yerinde olacaktır. Ayrıca, çalışmada incelenen çeşitlerden Miranda'nın kuraklık stresinde, çoğu özellikler yönünden ıslah çalışmalarında ebeveyn olarak rahatlıkla kullanılabileceği anlaşılmaktadır.
- MakaleYayıncıda açık erişim2014Scopus SJRQ1Characterization of rosehip (Rosa canina L.) seed and seed oil
Ilyasoǧlu, Huri
In this study, the nutritional composition and phytochemical composition of the rosehip seed, and the fatty acid and sterol compositions of the seed oil were investigated. The rosehip seed contained valuable phytochemicals such as phenolic compounds (2554 μg/g), carotenoids (2.92 μg/g), and ascorbic acid (1798 μg/g). Furthermore, the rosehip-seed oil was rich in polyunsaturated fatty acids, linoleic acid (54.05%), linolenic acid (19.37%), and phytosterols, mainly β-sitosterol (82.1%). The rosehip seed and seed oil were found to have antioxidant activity measured by trolox equivalent antioxidant capacity assay. It can be concluded that the rosehip seed and seed oil may be utilized as a source of phytonutrients.
AtıfScopus106WoS96OpenAlex111İncele