Sürdürülebilir Kalkınma Amaçları

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• 2

Yazarlar

• Acet, Tuba(2)
• Aljobair, Moneera O.(1)
• Arpa Zemzemoglu, Tuba Eda(1)
• Arslanoğlu, Hasan(1)
• Aydoğmuş, Ercan(1)
• Demirel, Maruf Hurşit(1)
• Deniz, Ilhan(1)
• Eren Çakar(1)
• Gül, Abdulkadir(1)
• Gürfidan, Remzi(1)
• Kilim, Oguzhan(1)
• Mohamed Ahmed, Isam A.(1)
• Okan, Onur Tolga(1)
• Ozcan, Kadriye(1)
• Tokatli Demirok, Nazan(1)
• Tokatli, Nazli(1)
• Türkol, Melikenur(1)
• Ulusoy, Esra(1)
• Yikmis, Seydi(1)
• Yinanç, Abdullah(1)
• Zengin, Gokhan(1)
• Öz, Mehmet(1)
• Özgen, İnanç(1)

• MakaleAçık Erişim2026Scopus SJRQ1/r/gumushane/13630
  Antibacterial efficacy of pyrolysis-derived plant fractions against resistant pathogens: a comparative evaluation using nutrient and Müller–Hinton agar

  Demirel, Maruf Hurşit; Gül, Abdulkadir; Aydoğmuş, Ercan; Özgen, İnanç; Arslanoğlu, Hasan

  BACKGROUND: This study investigates the antibacterial potential of pyrolysis-derived extracts from rosehip fruit (RF), orange peel (OP), corn silk (CS), spurge root (ER) and mullein leaf (ML) against antibiotic-resistant pathogens using two different culture media. Bioactive compounds were obtained via a PID-controlled pyrolysis system, and antibacterial activity was evaluated to clarify both extract efficacy and medium-dependent effects on bacterial growth and diffusion. RESULTS: Antibacterial activities were assessed using the agar well diffusion method, with ampicillin as a positive control, against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus faecalis. A key novelty of this work is the comparative evaluation of extract performance on nutrient agar (NA) and Müller–Hinton agar (MHA). Among all samples, the ML extract exhibited the strongest antibacterial activity across all tested strains, producing inhibition zones of 18.85 mm against E. coli and 17.15 mm against E. faecalis on NA, compared with 13.05 mm and 13.60 mm on MHA, respectively. CS and ER extracts showed moderate antibacterial effects, with consistently higher inhibition zones on NA than on MHA. Ampicillin generated substantially larger inhibition zones on NA (33.35 mm for E. coli and 34.45 mm for P. aeruginosa) compared with MHA (13.80 and 27.70 mm, respectively), confirming the strong influence of culture medium composition on measurable antibacterial activity. CONCLUSION: These results indicate that both plant extracts and ampicillin exhibit higher antibacterial activity on NA than on MHA. The pronounced efficacy of the ML extract highlights pyrolysis-derived plant fractions as promising natural antimicrobials and emphasizes the critical importance of culture medium selection.

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  AtıfScopus4·WoS5·OpenAlex5

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• MakaleAçık Erişim2026Scopus SJRQ1/r/gumushane/10348
  Thermosonication improves the bioactive properties and in vitro bioaccessibility of broccoli juice through integrated RSM and metaheuristic optimization

  Arpa Zemzemoglu, Tuba Eda; Tokatli Demirok, Nazan; Türkol, Melikenur; Gürfidan, Remzi; Kilim, Oguzhan; Tokatli, Nazli; Yikmis, Seydi; Mohamed Ahmed, Isam A.; Aljobair, Moneera O.; Yinanç, Abdullah

  Broccoli juice is highly nutritious, containing phenolic compounds, chlorophyll derivatives, antioxidants, and other biologically active phytochemicals; however, conventional thermal processing may reduce their stability and bioaccessibility. The aim of this study was to analyse the impact of thermosonication on the following properties of broccoli juice: bioactivity, antioxidant capacity, phenolic profile and in vitro bioaccessibility. Thermosonication conditions were optimized using Response Surface Methodology (RSM) integrated with the Gray Wolf Optimizer (GWO) and Particle Swarm Optimization (PSO) algorithms. Broccoli juice samples were subjected to conventional pasteurization and thermosonication under different processing conditions, and total chlorophyll, ascorbic acid (AA), ferric reducing antioxidant power (FRAP), total phenolic content (TPC), and individual phenolic compounds were evaluated. Digestive stability and post-digestion bioaccessibility were also assessed using a standardized in vitro gastrointestinal digestion model. The developed quadratic models exhibited high statistical significance for TPC and FRAP responses (p < 0.001), with coefficients of determination (R2) of 0.9949 and 0.9853, respectively. The optimum thermosonication conditions were identified as 40 degrees C, 6.75 min, and 64.04% amplitude, under which experimentally validated FRAP and TPC values reached 12.86 mmol TE/L and 149.77 mg GAE/100 ml, respectively. HPLC-DAD analysis showed that gallic acid and naringin were the pre-dominant phenolic compounds, and that thermosonication promoted greater phenolic retention than conventional pasteurization. In vitro digestion results demonstrated that thermosonicated broccoli juice maintained significantly higher levels of TPC, FRAP, chlorophyll, and AA throughout gastrointestinal digestion, with higher TPC recovery (30.45%) than pasteurized samples (26.22%), indicating improved post-digestion bioaccessibility of phenolic compounds. Similar improvements were observed for antioxidant capacity and chlorophyll retention. Furthermore, PSO and GWO optimization results showed strong agreement with RSM predictions, confirming the robustness of the proposed optimization strategy. Overall, thermosonication was shown to effectively and sustainably enhance the functional quality, antioxidant properties, phenolic stability, and digestive bioaccessibility of broccoli juice.

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  AtıfScopus1·WoS1·OpenAlex1

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• Yüksek Lisans TeziAçık Erişim2025/r/gumushane/21700
  Gelişmiş ve geleneksel yöntemlerle elde edilen sinirli ot (Plantago lanceolata) bitki ekstraksiyonlarının biyoaktif bileşenlerinin incelenmesi

  Eren Çakar

  Yapılan çalışmada sinirli ot (Plantago lanceolata) bitkisinin geleneksel ve gelişmiş (mikrodalga ve ultrases) ekstraksiyon yöntemleriyle ekstraktları hazırlanmış ve bu ekstraktların biyoaktif bileşenleri incelenmiştir. Ekstraktların antioksidan aktiviteleri Radikal süpürme kapasitesi (DPPH), Ferrik İyon İndirgeme (FRAP), Radikal nötralizasyonu (ABTS) şeklinde 3 farklı test yöntemiyle belirlenmiştir. Sinirli ot bitkisinin toplam fenolik ve flavonoid madde içeriği standart gallik asit ve kuarsetin kullanılarak analiz edilmiştir. Çalışılan antioksidan test yöntemleri arasından DPPH ve ABTS yöntemlerinde laboratuvar tipi mikrodalga ekstraktının diğer ekstraktlara göre daha yüksek sonuç verdiği belirlenmiştir. Başka bir antioksidan test yöntemi olan FRAP yönteminde ise su ekstraktının diğer ekstraktlara göre daha yüksek sonuç (2.02 ± 0.02A mg/g FeSO4) gösterdiği elde edilen sonuçlar arasındadır. Sinirli ot bitkisinin en yüksek toplam fenolik madde içeriği laboratuvar tipi mikrodalga ekstraktında (2.70 ± 0.13A mg/g GAE) olduğu belirlenirken toplam flavonoid içeriği en yüksek olan ekstraktın ise metanol ekstraktı (13.01 ± 0.27A mg/g QE) olduğu söylenebilir. Yapılan çalışma sonucunda sinirli ot bitkisinde yaş örneklerinde bulunan biyoaktif bileşiklerin, gelişmiş ekstraksiyon yöntemleriyle elde edilen ekstraktlarla yapılan analizlerinde daha etkili olduğu çalışmanın en belirgin sonuçlarındandır. Aynı zamanda sinirli ot bitkisinin antimikrobiyal aktivitesi B. cereus, E. coli, Y. enterocolitica, P. aeruginosa, S. typhimurium, C. albicans'a karşı disk difüzyon yöntemiyle belirlenmiştir. Elde edilen verilere göre bütün ekstraksiyonların C. albicans'a herhangi bir antimikrobiyal aktivitesinin olmadığı, en yüksek P.aeruginosa'ya karşı (17.6  0.01 mm), en düşük ise S. typhimurium'a karşı (6.6  0.01 mm) antimikrobiyal aktivite gösterdiği belirlenmiştir. Anahtar Kelimeler: Antimikrobiyal aktivite,Antioksidan aktivite, Biyoaktif bileşikler, Ekstraksiyon yöntemleri, Plantago lanceolata

  RDL DOI10.71008/gumushane.thesis.2025.288indekslendi
  İncele
• MakaleAçık Erişim2024/r/gumushane/15873
  Evaluation of Antioxidant Properties of Wild and Cultivated Blueberry Leaves and Their Phenolic Compound

  Okan, Onur Tolga; Ulusoy, Esra; Öz, Mehmet; Deniz, Ilhan

  Aim of study: This study aimed to investigate the antioxidant activity and polyphenol and flavonoid content of blueberry leaves, which could have positive effects on human health. Area of study: The research was conducted in three cities of Turkiye's Karadeniz region, where blueberry cultivation is prevalent: Giresun, Trabzon, and Rize. Material and method: In this study, 29 blueberry leaves (27 cultivated and two wild) were selected as sample materials. The total phenolic content (Folin-Ciocalteu method), total flavonoid content (aluminum (III) chloride method), and total antioxidant capacity (DPPH and FRAP) of the samples were analyzed. Phenolic characterization was performed using HPLC. Main results: The total phenolic content varied between 8.36 and 121.61 mg GAE/g, whereas the total flavonoid content ranged from 0.91 to 3.07 mg QE/g. The results revealed that blueberry leaves had high antioxidant activity and contained considerable amounts of polyphenols and flavonoids. Chlorogenic acid was identified as the dominant compound in all leaves samples. Research highlights: These findings indicate that blueberry leaves could be a valuable source of antioxidants in the food and cosmetic industries, comparable to the fruit itself.

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  AtıfWoS2·OpenAlex2

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• MakaleYalnız künye2021Scopus SJRQ2/r/gumushane/14754
  Determining the phenolic components by using HPLC and biological activity of Centaurea triumfetti

  Acet, Tuba

  Centaurea species belonging to Asteraceae family are traditionally used herbs in treating many diseases in Anatolia. In the present study, I aimed to determine the biological activities and phenolic contents of the extracts of the aerial parts of Centaurea triumfetti collected from areas with extreme climatic conditions. The determination of antioxidant activity was performed using in vitro assays such as ABTS (2,2-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) and DPPH (1,1-diphenyl-2-picrylhydrazyl). Disc diffusion and microdilution methods were used for determine of antimicrobial activity. Besides that, the diabetes-related inhibition activities of enzymes such as alpha-glucosidase and alpha-amylase were determined using colorimetric methods. The phenolic components of the extracts were analysed by using HPLC. The biological activity of ethyl acetate extracts of the stem was found to be higher those than that of other extracts. This extract was also found to have high antimicrobial and enzyme inhibition activity. Moreover, the major component of the extract was found to be chlorogenic acid. In conclusion, these results suggest that C. triumfetti has the potential for pharmaceutical usage.

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  AtıfScopus18·WoS21·OpenAlex17

  İncele
• MakaleAçık Erişim2020Scopus SJRQ2/r/gumushane/13234
  An assessment of phenolic profiles, fatty acid compositions, and biological activities of two Helichrysum species: H. plicatum and H. chionophilum

  Acet, Tuba; Ozcan, Kadriye; Zengin, Gokhan

  In the present study, we aimed to search and compare the biological activities of the ethanol (EtOH), methanol (MeOH), and ethylacetate (EtOAc) solvent extracts of the flower, stem, and root parts of two Helichrysum plants (H. chionophilum (Hc) and H. plicatum subsp. plicatum (Hp)). The antioxidant properties were determined by using (2,2-diphenyl-1-picrylhydrazyl) (DPPH) and ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The enzyme inhibitory effects of the extracts were investigated on butyrylcholinesterase (BChE), acetylcholinesterase (AChE), α-glucosidase, and α-amylase. Palmitic acid (C 16:0) was also determined as major fatty acids in the tested oils (31.21%–67.68%). In both plants, it was found that the EtOAc extracts of the flowers had a strong antioxidant and enzyme inhibitory effect. In conclusion, the results obtained in the present study showed that H. chionophilum and H. plicatum can be seen as a promising source for the natural bioactive compounds that can be used in therapeutic applications. Practical applications: The members of the genus Helichrysum have been widely taken for therapeutic purposes in traditional medicine as well as food. In this context, we investigated the chemical characterization and biological activities of two Helichrysum species extracts (H. chionophilum and H. plicatum subsp. plicatum). Antioxidant capacity, enzyme inhibition and anti-microbial effects were tested for biological activities. Chemical characterization was identified by high performance liquid chromatography (HPLC) (for phenolic) and gas chromatography-flame ioanization detector (GC-FID) (for fatty acids). Based on our findings, the species may be valuable for designing novel food products.

  AtıfScopus13·WoS10·OpenAlex24

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