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- MakaleAçık Erişim2026Potentially Toxic Metal Levels in Cheeses Produced in Türkiye: Regional Variation, Milk Source, Ripening Stage, Production Type, and Associated Dietary Exposure and Health Risk
Gürmeriç, Hüseyin Ender; Şengül, Mustafa; Basaran, Burhan
This study investigated potentially toxic metal (PTM) levels in cheeses produced in different regions of Türkiye and evaluated the associated dietary exposure and non-carcinogenic health risk. A total of 84 cheese samples were collected from seven geographical regions and classified according to milk source, ripening stage, and production type. After microwave-assisted acid digestion, PTM levels were quantified by inductively coupled plasma mass spectrometry (ICP-MS), and exposure and non-carcinogenic risk were evaluated using Estimated Daily Intake (EDI), Target Hazard Quotient (THQ), and Hazard Index (HI). Aluminium (Al), iron (Fe), and zinc (Zn) ranged from <0.00215 to 7.29,<0.00769 to 38.8, and 0.68 to 56.6 mg/kg wet weight, respectively, whereas chromium (Cr), nickel (Ni), copper (Cu), selenium (Se), cadmium (Cd), and lead (Pb) ranged from <0.58 to 244, <1.26 to 369, <1.88 to 4067, <0.91 to 1378, <0.06 to 12.3, and <2.19 to 1754 µg/kg wet weight, respectively. Values marked with “<” represent concentrations below the limit of quantification (LOQ). Arsenic (As) was not detected in any sample. Significant differences were observed for selected PTMs according to ripening stage, milk source, production type, and region (p<0.05). The toxicological contribution (TC) values for nutritional PTM exposure were low. THQ and HI values remained below 1, suggesting a low overall non-carcinogenic risk; however, Pb exceedances in some samples indicate the need for continued PTM monitoring.
- MakaleYayıncıda açık erişim2025The Effect of Heavy Metals in Mining Emissions on Worker’s Blood Lead Levels: A Case Study of The Gumushane Zn-Pb Mine, Turkey
Bozbeyoğlu, Pınar; Doğan, Onur; Budak, Burhan
The wastewater from mining facilities contains toxic elements such as arsenic (As), cadmium (Cd), chromium (Cr), manganese (Mn), zinc (Zn), and lead (Pb). If not disposed of correctly, it can lead to environmental pollution in case of accidents or overflow. Lead-zinc mining activities pose a significant risk of high blood lead levels (BLLs) among workers. Therefore, monitoring the blood lead levels of workers exposed to these heavy metals, especially lead, is crucial. This study aims to determine the levels of potentially harmful elements in the wastewater dam of the largest Zn-Pb mine in the Black Sea Region. It also seeks to assess the environmental and human health risks comprehensively. Additionally, the study aims to establish a relationship between the levels of lead in the mining wastewater in Gumushane and the lead levels accumulated in the blood of workers exposed to this metal. The study analyzed heavy metals such as As, Zn, Cu, Sb, and Pb in mining wastewater using Inductively Coupled Plasma – Mass Spectrometer (ICP-MS). The results indicated high levels of Pb in the studied wastewater. Furthermore, the blood lead levels of workers in the mining area (n=30; mean: 7.42 μg/dL) exceeded background levels (>40 μg/dL). These results suggest a significant relationship between the presence of lead in wastewater and high lead levels in the blood of individuals with high exposure to concentrated lead.
- MakaleYalnız künye2021Determination of Angelica archangelica’s Antioxidant Capacity and Mineral Content
Topal, Meryem; Ozturk Sarıkaya, S. Beyza; Topal, Fevzi
The aim of this study was to determine the mineral contents by ICP-MS and the antioxidant capacity of Angelica archangelica plant, which is not well known in the literature. For this purpose, ethyl alcohol extracts of the branches and leaves of the plant; different bioanalytical methods such as reducing capacity by Fe3+−Fe2+ transformation method, Fe3+-TPTZ reducing capacity by FRAP method, Cu2+-Cu+ reducing capacity by CUPRAC method, the ferric ions (Fe2+) chelating activity by using bipyridyl reagent, DPPH (1,1-diphenyl-2-picryl-hydrazyl) free radical, DMPD (N,N-dimethyl-p-phenylenediamine), ABTS (2,2’-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical scavenging activities, total antioxidant activity determination according to thiocyanate method, total phenolic and total flavonoid activity were used. As standard, BHT, BHA, α-Tocopherol, Trolox were used. A. archangelica branches and leaves demonstrated 88.13 % and 93.90 % inhibition of linoleic acid emulsion peroxidation at 20 mg mL−1 concentration. Also, it was determined that both leaves and branches of A. archangelica plant were dense with P, Mg, Ca and K minerals with ICP-MS device. It is considered that the results of the manuscript will guide the antioxidant studies, medicine, cosmetics, pharmacology and food sector.