Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleAçık Erişim2026Impacts of Phenolic Compounds Alone and in Combination with Natural Substances or Drugs on Cancer Cells
Budak, Burhan; Sarikaya, Sevim Beyza Ozturk
Phenolic compounds (PCs) are secondary metabolites found in the root and flower parts of plants that help protect the plant from pathogens. The amount and content of the plant species and the environment in which they live vary. Because PCs have antioxidant properties, they have a preventive effect against oxidising substances. Therefore, PCs in the human diet contribute to the prevention of cancer, osteoporosis, diabetes, and many other diseases. Cancer is the most dangerous and deadly disease among these diseases today. Although many chemotherapeutic drugs are used against cancer, the tendency to use other drugs or other applications has increased because the effectiveness of chemotherapeutic drugs is low and healthy cells are damaged in the process. PCs boost the effectiveness of chemotherapeutic drugs against cancer cells while, preserving the health of other cells. In this review, in vivo and in vitro studies conducted in cancer lines, applications of PCs alone, combined applications of PCs with natural substances, and the effects of PCs with drugs were investigated and discussed. In conclusion, gallic acid, ellagic acid, caffeic acid, and ferulic acid are frequently used in cancer treatment. These findings highlight the potential of PCs as versatile adjuvants in cancer treatment, which can increase drug efficacy, protect healthy cells, and minimise toxicity. Consequently, they highlight the therapeutic potential of PCs as complementary agents in cancer treatment strategies.
- MakaleYayıncıda açık erişim2025The Effect of Heavy Metals in Mining Emissions on Worker’s Blood Lead Levels: A Case Study of The Gumushane Zn-Pb Mine, Turkey
Bozbeyoğlu, Pınar; Doğan, Onur; Budak, Burhan
The wastewater from mining facilities contains toxic elements such as arsenic (As), cadmium (Cd), chromium (Cr), manganese (Mn), zinc (Zn), and lead (Pb). If not disposed of correctly, it can lead to environmental pollution in case of accidents or overflow. Lead-zinc mining activities pose a significant risk of high blood lead levels (BLLs) among workers. Therefore, monitoring the blood lead levels of workers exposed to these heavy metals, especially lead, is crucial. This study aims to determine the levels of potentially harmful elements in the wastewater dam of the largest Zn-Pb mine in the Black Sea Region. It also seeks to assess the environmental and human health risks comprehensively. Additionally, the study aims to establish a relationship between the levels of lead in the mining wastewater in Gumushane and the lead levels accumulated in the blood of workers exposed to this metal. The study analyzed heavy metals such as As, Zn, Cu, Sb, and Pb in mining wastewater using Inductively Coupled Plasma – Mass Spectrometer (ICP-MS). The results indicated high levels of Pb in the studied wastewater. Furthermore, the blood lead levels of workers in the mining area (n=30; mean: 7.42 μg/dL) exceeded background levels (>40 μg/dL). These results suggest a significant relationship between the presence of lead in wastewater and high lead levels in the blood of individuals with high exposure to concentrated lead.
- Derleme MakaleAçık Erişim2022Spirulina: Özellikleri, Faydaları ve Sağlık-Besin İlişkisi
Sarikaya, Sevim Beyza Ozturk; Budak, Burhan
Spirulina, antioksidanlar, esansiyel amino asitler, yüksek kaliteli proteinler ve esansiyel doymamış yağlar gibi birçok faydalı içeriği nedeniyle bilimsel olarak birçok alanda kullanılan doğal bir üründür. Spirulina, A, C, E ve B vitaminleri ve kalsiyum, çinko, magnezyum ve selenyum gibi birçok mineral içeriğine sahip olduğu için besleyiciliği yoğun bir gıda olarak bilinir. Özellikle selenyum ve C vitamini antioksidan özelliklere sahip vitaminlerdir ve hücrelerimizi ve dokularımızı olası hasarlara karşı korurlar. Bu özelliklerinden dolayı Spirulina gıda, kozmetik ve tıp alanlarında kullanılmaktadır. Antioksidan özellikler içerdiğinden artrit, diyabet, anemi, kanser ve kardiyovasküler hastalıklar gibi çeşitli hastalıklarda kullanılır. Birçok çalışmada Spirulina'nın özellikleri araştırılmış ve olumlu sonuçlar elde edilmiştir. Ayrıca, Spirulina'nın farmakoloji, kozmetik, tıp ve gıda gibi alanlarda kullanımıyla da önemi artmıştır. Bu çalışmada, sayısız faydası bulunan bu mikroalglerin önemi günümüz yaklaşımlarıyla ve biyokimya, biyoteknoloji ve tıp alanlarında yapılan çalışmalarla vurgulanmaya çalışılmıştır.