Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Akay, Seref(2)
- Baltaci, Cemalettin(2)
- Baltacı, Cemalettin(2)
- Bozbeyoğlu, Pınar(2)
- Ejder, Nebahat(2)
- Gül, Abdulkadir(2)
- Karpuz, Ömer(2)
- Özad Düzgün, Azer(2)
- Akar, Bülent(1)
- Akar, Zeynep(1)
- Akay, Şeref(1)
- Akdogan, Arda(1)
- Akmese, Osman(1)
- Aydoğan, Nebahat(1)
- Demir, Semra(1)
- Gedikli, Hasan(1)
- Gülen, Jale(1)
- Hammoudeh, Rama(1)
- Hasan Gedikli(1)
- Karpuz, Omer(1)
- Kobya, Havva N.(1)
- Sefaoğlu, Melike(1)
- Yüksel, Gamze(1)
Yayınlar
- MakaleAçık Erişim2026GREEN SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF IRON OXIDE NANOPARTICLES FROM ROBINIA PSEUDOACACIA L. FRUITS FOR DYE REMOVAL FROM AQUEOUS SOLUTIONS
Demir, Semra; Akar, Bülent; Baltaci, Cemalettin
In this study, iron oxide nanoparticles were produced and characterized using a green synthesis method with Robinia pseudoacacia fruits. The structural and functional properties of the nanoparticles were investigated using XRD, TEM/EDX, and FTIR analyses. The results indicated that the produced iron oxide nanoparticles had nanoscale particle sizes and exhibited a poorly crystalline (predominantly amorphous) structure according to XRD analysis. The comparative adsorption performance of the synthesized FeONPs and fruit powder in the removal of malachite green (MG), phenol red (PR) and methylene blue (MB) from aqueous solutions was evaluated. According to the results, the adsorption capacity followed the order MB> MG > PR. FeONPs exhibited consistently higher Qₑ values across all dye systems compared to the fruit powder. High removal efficiencies were obtained at low and moderate initial concentrations, while increasing the adsorbent dose enhanced the overall removal but resulted in a reduction in the adsorption capacity per unit mass. The obtained findings indicate that biosynthesized iron oxide nanoparticles can be used as an efficient and environmentally friendly adsorbent for eliminating environmental pollutants.
- MakaleYalnız künye2026Green Synthesis of Multifunctional Ag/ZnO Nanoparticles Using Vitis labrusca L. Extract: Bioactivity, Malachite Green Adsorption, and HMF Removal
Hammoudeh, Rama; Bozbeyoğlu, Pınar; Karpuz, Ömer; Gül, Abdulkadir; Ejder, Nebahat; Baltacı, Cemalettin
In this study, Ag/ZnO nanoparticles (Ag/ZnO NPs) were synthesized via a green route using Vitis labrusca L. extract and evaluated for their bioactive, environmental performance. BM-1 and BM-2 were prepared under different precursor/extract ratios and pH conditions to assess the influence of synthesis parameters. UV–Vis, FT-IR, XRD, HRTEM, DSC, and EDX analyses indicated the successful formation of Ag/ZnO nanostructures with distinct physicochemical features. HRTEM analysis determined that BM-1 exhibited an average particle diameter of 23.18 ± 11.84 nm, while BM-2 demonstrated a mean size of 6.14 ± 1.30 nm. The corresponding relative size-dispersion values were 0.261 for BM-1 and 0.045 for BM-2, indicating a more uniform particle size distribution for BM-2. Antioxidant assays showed that BM-2 exhibited the strongest overall antioxidant performance in DPPH, ABTS•⁺, Fe3+, and Cu2+ assays. Both NPs exhibited antibacterial activity against Gram-positive and Gram-negative bacteria and showed stronger effects than the grape extract alone. Cytotoxicity assays revealed dose-dependent inhibition in A549 and HeLa cancer cells, while lower toxicity was observed in normal ARPE-19 cells, suggesting cell-type-dependent biological response. In adsorption experiments, the NPs effectively removed malachite green, with isotherm analysis providing stronger support for the Langmuir model for BM-1 and comparable Langmuir and Freundlich fits for BM-2, while the pseudo-second-order model provided the best description of the adsorption kinetics. The maximum dye adsorption capacities were 85.5 mg/g for BM-1 and 101.3 mg/g for BM-2. Under optimum conditions (5.0 g/L NPs, 240 min), the highest HMF removal efficiencies reached 44.49% for BM-2 in standard aqueous solutions, whereas competitive matrix interactions in apple juice limited the maximum efficiency to 29.27%. Overall, this study highlights the value of integrating green synthesis, bioactivity, dye adsorption, and food-related contaminant removal within a single Ag/ZnO nanoplatform.
- MakaleAçık Erişim2025Green synthesis of iron and silver nanoparticles from aqueous extract of buckwheat husk waste: antibacterial, cytotoxic, and dye decolorization properties
Karpuz, Ömer; Baltacı, Cemalettin; Gül, Abdulkadir; Gülen, Jale; Bozbeyoğlu, Pınar; Aydoğan, Nebahat
Iron oxide (BHFeNP) and silver nanoparticles (BHAgNP) were produced using a green synthesis method through the extract of buckwheat husk (BH) waste to remove dye pollutants from water bodies in this study. The BHFeNP and BHAgNP were characterized by TEM, SEM, XRD, EDX, and FTIR techniques. Then, the methylene blue (MB) removal performance of the synthesized nanoparticles (NPs) was investigated. MB adsorption experiments showed that BHFeNPs were more dependent on temperature, adsorbent amount, and pH, while BHAgNPs notably depended on adsorbent amount, initial MB concentration, and pH. BHAgNPs had higher adsorption rates than BHFeNPs, and the Langmuir isotherm was more suitable for the adsorption process. BHAgNP and BHFeNP were shown to have the maximum adsorption capacities of 96.3 and 53.4 mg/g at pH 8 and 25 °C, respectively, in the presence of 0.25 g/L NP. Kinetic and thermodynamic calculations revealed that MB adsorption was spontaneously endothermic and supported the pseudo-second-order kinetic model. The antibacterial potentials of BHFeNPs and BHAgNPs were investigated against two gram-negative (Escherichia coli and Pseudomonas aeruginosa) and two gram-positive (Enterococcus faecalis and Staphylococcus aureus) bacterial strains. BHAgNPs exhibited a higher antibacterial activity against the strains used. In cytotoxicity studies with ARPE-19, A549, HeLa, and DU-145 cell lines, it was observed that BHAgNP had a greater cell growth inhibition effect than BHFeNP and BH extract. Examining the morphological changes in the cells exhibited that BHAgNP significantly inhibited A549 and ARPE-19. Reusability studies of the generated NPs revealed MB removal capabilities of 92.5% and above after the fifth stage. The present study demonstrates that BHAgNP and BHFeNPs are viable nanoadsorbents for the elimination of environmental pollution due to their excellent removal performances and stable adsorbent characteristics.
- MakaleAçık Erişim2024Investigation of Antibiofilm and Antibacterial Properties of Green Synthesized Silver Nanoparticles from Aqueous Extract of Rumex sp.
Akay, Seref; Yüksel, Gamze; Özad Düzgün, Azer
The decrease in the effectiveness of conventional drugs as a result of the growth of resistance to antibiotics has increased the need for innovative tools to control the infections. At this point, metallic nanoparticles, in particular silver nanoparticles, have appeared as a promising method. In the current study, the extract of Rumex sp. (Labada, dock) leaves was used as a reducing agent for the formation of silver nanoparticles. Unlike similar studies, in this study the synthesis conditions were optimized by changing the extract ratio and silver nitrate concentration. Morphological investigations of synthesized silver nanoparticles showed that spherical homogeneous particles at size under 100 nm had been produced. SEM/EDS and FTIR analyses showed that plant components are involved in the synthesis of nanoparticles. It was also determined that higher extract ratio reduced nanoparticle size. The antimicrobial effects of the synthesized nanoparticles against Gram-positive and Gram-negative bacteria were tested, and it was determined that all nanoparticles exhibited activity against both groups. Rumex sp. silver nanoparticles (NPs) were revealed to exhibit antibiofilm activity against three different isolates with moderate and strong biofilm-forming ability. The NPs reduced the biofilm-forming capacity of Acinetobacter baumannii and Klebsiella pneumonaie by 2.66-fold and 3.25-fold, whereas they decreased the Escherichia coli biofilm-forming capacity by 1.25-fold. The investigation of microbial biofilm could play an important role in developing new strategies for treatment options. Our results suggest that Rumex sp. silver NPs may have a high potential for use in the treatment of pathogenic strains.
- Derleme MakaleAçık Erişim2024Aflatoxin Detoxification by Biosynthesized Iron Oxide Nanoparticles Using Green and Black Tea Extracts
Gedikli, Hasan; Akdogan, Arda; Karpuz, Omer; Akmese, Osman; Kobya, Havva N.; Baltaci, Cemalettin
Researchers have recently been interested in employing nanoparticles (NPs) obtained from herbal extracts through green synthesis for various applications. This study investigated the detoxification of aflatoxins, which are toxic substances produced by molds Aspergillus flavus and Aspergillus parasiticus. The present work examined the levels of aflatoxins in hazelnut and peanut puree. Turkish black tea extract (BTE), Turkish green tea extract (GTE), green synthesized black tea-based iron oxide nanoparticles (BTFeONPs), and green tea-based iron oxide nanoparticles (GTFeONPs) were produced for aflatoxin removal. Characterizations and various antioxidant and antimicrobial activities of the tea extracts and iron oxide nanoparticles (FeONPs) were investigated. The aflatoxin levels of hazelnut puree used for this study were 6.57 ± 0.06 µg/kg for aflatoxin B1 and 13.03 ± 0.16 µg/kg for total aflatoxin, whereas the aflatoxin levels of (AFLB1) peanut puree were 7.79 ± 0.15 µg/kg for AFLB1 and 15.21 ± 0.12 µg/kg for total aflatoxin. Using soluble BTE resulted in a 40 to 50% decrease in aflatoxin levels in hazelnut and peanut purees, while soluble GTE led to a 30 to 45% decrease. Meanwhile, using BTFeONPs and GTFeONPs resulted in a 33 to 48% and 40 to 50% decrease, respectively, in aflatoxin levels in hazelnut and peanut purees.
- MakaleAçık Erişim2024Determination of the Cytotoxicity and Antibiofilm Potential Effect of Equisetum arvense Silver Nanoparticles
Akar, Zeynep; Akay, Seref; Ejder, Nebahat; Özad Düzgün, Azer
This study aimed to synthesize and characterize silver nanoparticles (AgNPs) by green synthesis from Equisetum arvense (Ea) extracts and to investigate their cytotoxicity, antibiofilm activity, and α-glucosidase enzyme inhibition. Diverse characterization techniques were applied to verify the production of nanoparticles. SEM examination confirmed that the size of nanoparticles is in the range of 40–60 nm. Also, interactions between silver and natural compounds of plant extract were confirmed through FT-IR and EDX analyses. It was determined that Equisetum arvense silver nanoparticles had antibiofilm activity against three different clinical strains with high biofilm-forming ability. AgNPs reduced the biofilm-forming capacity of clinical A. baumannii isolate with strong biofilm-forming capacity by approximately twofold, while the capacity of clinical K.pneumonaie and E.coli isolates decreased by 1.5 and 1.2 fold, respectively. The α-glucosidase enzyme inhibition potential of the AgNPs, which is determined as 93.50%, was higher than the plant extract with, and the α- 30.37%. MTT was performed to assess whether incubation of nanoparticles with A549 and ARPE-19 cell lines affected their viability, and a dramatic reduction in cell growth inhibition of both A549 and ARPE-19 cells was observed. It has been shown that A549 cells treated with 200 and 150 µg/mL nanoparticles had less cell proliferation compared to control cells at 24-h and 48-h incubation time. According to these results, Ea-derived AgNPs appear to have potential anticancer activity against A549 cancer cells. Investigating the effects of green synthesis nanoparticles on microbial biofilm and various tumors may be important for developing new therapies. The outcomes of this study have showed that Ea-AgNPsmay have a high potential both in the treatment of pathogenic strains that form biofilms, as well as in anticancer therapy use.
- Yüksek Lisans TeziAçık Erişim2022Türk siyah ve yeşil çayı ekstraklarının ve bu ekstraklardan yeşil sentez yoluyla üretilen demir nano parçacıklarının bazı gıdalarda aflatoksinlerin azaltılması üzerine bir araştırma
Hasan Gedikli
Aflatoksinler, başlıca Aspergillus flavus ve Aspergillus parasiticus küfleri tarafından oluşturulan toksik maddelerdir. Aflatoksinlerin detoksifikasyonu fiziksel, kimyasal ve biyolojik yöntemler ile gerçekleştirilmektedir. Bu biyolojik yöntemlerde bitkisel ekstrakların kullanımı önemli bir rol oynamaktadır. Bu bitkisel ekstraklardan yeşil sentez yolu ile elde edilen nanoparçacıklar son zamanlarda araştırmacıların dikkatini çekmektedir. Bu araştırmada, Türk siyah ve yeşil çaylarından elde edilen ekstraklar kullanılarak aflatoksinlerin fındık ve fıstık püresindeki azalma seviyeleri incelenmiştir. Siyah ve yeşil çay ekstraklarından yeşil sentez yolu ile demir nanoparçacıklar üretilmiştir. Üretilen bu nanoparçacıklar kullanılarak fındık ve fıstık pürelerinin aflatoksin seviyelerinin azalması amaçlanmıştır. Bu çalışma için kullanılan fındık püresinin aflatoksin düzeyleri aflatoksin B1 için 6.57±0.06 µg/kg ve toplam aflatoksin için 13.03±0.16 µg/kg'dır. Fıstık püresinin aflatoksin düzeyleri aflatoksin B1 için 7.79±0.15 µg/kg ve toplam aflatoksin için 15.21±0.12 µg/kg'dır. Bu çalışma sonucunda, siyah çayın çözünebilir ekstraktı ile muamele edilmiş fındık ve fıstık pürelerinin aflatoksin düzeylerinde %40-50 azalma, yeşil çayın çözünebilir ekstraktı ile muamele edilmiş fındık ve fıstık pürelerinin aflatoksin düzeylerinde %30-45 azalma, siyah çay demiroksit nanoparçacıklar ile muamele edilmiş fındık ve fıstık pürelerinin aflatoksin düzeylerinde %33-48 azalma, yeşil çay demiroksit nanoparçacıklar ile muamele edilmiş fındık ve fıstık pürelerinin aflatoksin düzeylerinde %40-50 azalma gözlenmiştir.
- MakaleAçık Erişim2021Production and characterization of zinc oxide nanoparticles in microsystems via green synthesis; [Yeşil sentez yoluyla mikrosistemlerde çinko oksit nanopartiküllerin üretimi ve karakterizasyonu]
Akay, Şeref; Sefaoğlu, Melike
Nanoparticles (NP), which can be produced for many different fields and purposes; are at size vary from nanometer to a micrometer. These particles can be prepared by different approaches such as chemical, physical and biological methods. However, the biological approach is the most promising approach among other methods due to its simplicity and environmentally friendly conditions. The production of the nanoparticle by means of a biological approach does not require any high temperature, acidic/basic conditions and hazardous chemicals. Therefore, this method is named “green synthesis”. Development in microtechnology has had profound effects in many areas such as drug discovery, biology, diagnosis, and tissue engineering. Microfluidics which focuses on the processing of liquids in microscale systems has attracted wide attention in the production process of nanoparticles due to precise control and fast mixing. The main purpose of this study is to produce and characterize metal nanoparticles by combining microsystems and green synthesis approaches. For this purpose, in the first step, the design of microsystems that suitable for the flow of different phases was performed. In the second step, ZnO nanoparticle synthesis was carried out using the red cabbage (Brassica oleracea var.capitata f. Rubra) extracts. The synthesis of nanoparticles achieved by optimizing different parameters such as; extract: zinc ratio, zinc solution concentration, flow rates, and flow rates ratio in the microsystem and temperature. The results showed that the herbal red cabbage components can be used for the green synthesis of ZnO nanoparticles.