Sürdürülebilir Kalkınma Amaçları

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Yazarlar

• Koçak, Tevfik(2)
• Acar-Tek, Nilufer(1)
• Akin, Meleksen(1)
• Arslan, Neslihan(1)
• Atuk Kahraman, Tutku(1)
• Bayraktar, Bulent(1)
• Bektemur, Güven(1)
• Borlu, Murat(1)
• Bozkır, Eda(1)
• Eker, Hasan Hüseyin(1)
• Ergün, Mehmet Ali(1)
• Icer, Yusuf(1)
• Karaalp, Musa(1)
• Kaya, Hacer(1)
• Konyalıgil Öztürk, Nurefşan(1)
• Kurtbeyoğlu, Emine(1)
• Mercan, Sümeyye(1)
• Mucaz, Meltem(1)
• Ozkaya, Emin(1)
• Sahinoz, Saime(1)
• Taşdemir, Mustafa(1)
• Tekce, Emre(1)
• Turunc, Eylul(1)
• Yesil, Suleyman(1)
• Yilmaz, Birsen(1)
• Çiçek, Betül(1)
• Çınar, Salih Levent(1)

• MakaleYalnız künye2025Scopus SJRQ3/r/gumushane/11291
  The interaction between the Mediterranean diet, obesity, and disease severity: A case–control study on psoriatic patients

  Konyalıgil Öztürk, Nurefşan; Kurtbeyoğlu, Emine; Atuk Kahraman, Tutku; Çiçek, Betül; Çınar, Salih Levent; Borlu, Murat

  Background: Psoriasis is a chronic inflammatory disease that can be influenced by nutritional status and dietary habits. In particular, adherence to the Mediterranean diet, known for its anti-inflammatory properties, is increasingly being investigated in relation to disease severity and nutritional status. Aims: This case–control study, including 50 psoriatic patients and 40 healthy controls, aimed to examine the correlation between adherence to the Mediterranean diet and disease severity, nutritional status, and disease presence in patients with psoriasis. Methods: The clinical severity of psoriasis was assessed using the Psoriasis Area and Severity Index (PASI) score. Anthropometric measurements were taken, and body composition was determined using bioelectrical impedance analysis. All participants’ Mediterranean Diet Adherence Screener (PREDIMED) scores and 24-h food consumption records were evaluated. Results: The body weight (BW), waist circumference (WC), hip circumference (HC), and fat mass (FM) values of psoriatic patients were found to be significantly higher than those of the healthy control group (p < 0.05). The PREDIMED score of psoriatic patients was found to be significantly lower than that of the control group (p < 0.001). A negative correlation was observed between the PREDIMED score and BW, FM, and HC (p < 0.05). PASI levels decreased as PREDIMED scores increased (r = −0.314, p = 0.048). According to logistic regression analysis, after adjusting for age and sex, the likelihood of being healthy was approximately 6.363 times higher in those with high adherence to the Mediterranean diet (p < 0.001). Conclusion: When psoriatic patients were compared with healthy controls, significant differences were observed in PREDIMED scores. Notably, greater adherence to the Mediterranean diet was associated with reduced disease severity, suggesting a potential mitigating effect even in the presence of obesity.

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  AtıfScopus1

  İncele
• MakaleAçık Erişim2025Scopus SJRQ2/r/gumushane/10402
  Could GSTP1, PTEN and NKX3.1 gene expression be novel markers in the relationship between prostate cancer and epigenetics?

  Koçak, Tevfik; Acar-Tek, Nilufer; Yesil, Suleyman; Ergün, Mehmet Ali; Icer, Yusuf

  Background: Although numerous treatment modalities exist for Prostate Cancer (PCa) with a complex pathophysiology, a significant worldwide health concern for males, early identification remains the paramount factor influencing disease prognosis. Proposed new biomarkers, including GSTP1, PTEN, and NKX3.1, may provide predictive and prognostic functions, hence enhancing the efficacy of PSA in diagnosing prostate cancer. Epigenetic variables associated with nutrition influence the blood gene expression levels of the new biomarkers GSTP1, PTEN, and NKX3.1. This study aimed to elucidate the correlation between nutrition-related epigenetic variables and the expression of the tumor suppressor genes GSTP1, PTEN, and NKX3.1 in benign prostate and prostate cancer patients. Methods: This study was conducted with 41 newly diagnosed prostate cancer and 42 benign prostate patients, all aged 40 years and older. Participants had specific anthropometric measurements taken, and seven-day food records were kept. Serum levels of novel biochemical markers GSTP1, PTEN, and NKX3.1 were measured using an Enzyme-Linked Immunosorbent Assay (ELISA) method. Expression analyses of tumor-protective GSTP1, PTEN, and NKX3.1 genes were performed on prostate tissues obtained from fresh prostate biopsies taken from the groups and were associated with nutritional status. Results: A significant relationship was found between the serum levels of GSTP1, PTEN, and NKX3.1, which are important in the formation and treatment of prostate cancer, and Gleason grade, tumor stage, and surgical margin status (p < 0.05). However, significant relationships were found between many macro and micronutrients obtained from the dietary pattern and effective in epigenetic pathways and GSTP1, PTEN, and NKX3.1 gene expressions (p < 0.05). Conclusions: The findings of this investigation corroborated the notion that prospective novel markers, including GSTP1, PTEN, and NKX3.1, may serve predictive and prognostic functions in prostate cancer, hence enhancing the efficacy of PSA in its diagnosis. Dietary trends may influence the optimization of many epigenetic processes. Targeted therapeutic nutritional interventions designed to enhance gene expression will facilitate the formulation of prostate cancer prevention methods.

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  İncele
• Derleme MakaleYayıncıda açık erişim2024Scopus SJRQ1/r/gumushane/14102
  From Garden to Pillow: Understanding the Relationship between Plant-Based Nutrition and Quality of Sleep

  Arslan, Neslihan; Bozkır, Eda; Koçak, Tevfik; Akin, Meleksen; Yilmaz, Birsen

  The effect of diet on sleep quality has been addressed in many studies; however, whether/how plant-based diets (PBDs) impact sleep-related parameters has not been explored in detail. This review aims to give an overview of the components of PBDs and the possible mechanisms through which PBDs may improve sleep quality. Studies have indicated that diets such as PBDs, which are typically high in fruits, vegetables, nuts, seeds, whole grains, and fiber, are associated with better sleep outcomes, including less fragmented sleep and improved sleep duration. Several mechanisms may explain how PBDs impact and/or improve sleep outcomes. Firstly, PBDs are characteristically rich in certain nutrients, such as magnesium and vitamin B6, which have been associated with improved sleep patterns. Secondly, PBDs are often lower in saturated fats and higher in fiber, which may contribute to better overall health, including sleep quality. Additionally, plant bioactive compounds like phytochemicals and antioxidants in fruits, vegetables, and herbs may have sleep-promoting effects. According to available data, PBD and Mediterranean diet elements promise to enhance sleep quality; however, it is crucial to note that diets should be customized based on each person’s needs.

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  AtıfScopus20·WoS17·OpenAlex21

  İncele
• MakaleAçık Erişim2020Scopus SJRQ2/r/gumushane/14786
  The impact of dietary tarragon (Artemisia dracunculus) on serum apelin, brain-derived neurotrophic factor, cardiac troponin concentrations and histopathology of liver tissue in laying hens housed at different stocking densities

  Bayraktar, Bulent; Tekce, Emre; Kaya, Hacer; Karaalp, Musa; Turunc, Eylul

  Due to its association with several other stress factors (poultry house gases, inadequate ventilation, heat, cold and poor hygiene), the high stocking density is a major stress factor that adversely affects the health and performance of poultry and the quality of the poultry products. Therefore, this experimental study was aimed at analysing the impact of different doses of dietary tarragon (Artemisia dracunculus) on the serum apelin, plasma brain-derived neurotrophic factor (p-BDNF), and cardiac troponin I (cTnI) concentrations, and the correlation between these indicators in laying hens housed at different stocking densities. The aim of this study is to investigate the effects of adding tarragon in different ratios to laying hen rations in the 2ndovulation period on the cTnI, apelin, and BDNF hormone concentrations and the liver histopathology. The experiment was carried out over a period of eight weeks, with 192 Lohman Brown commercial hybrids at 50 weeks of age. Eight groups (four replicates each), composed of laying hens of equal body weight, which were housed at stocking densities of 580 cm2/hen and 810 cm2/hen and received 0, 1, 5 and 10 mmol/kg of tarragon (Artemisia dracunculus) in the feed, were established. At the end of the trial, 96 of the housed egg-laying hens (3 birds in each subgroup, a total of 12 birds in each group) were randomly selected and blood samples were taken from the vena subcutanea ulnaris. The samples collected were analysed for the apelin, p-BDNF, and cTnI contents. The analysis results demonstrated that tarragon supplementation had no effect on the serum apelin, p-BDNF and cTnI concentrations (P > 0.05). The Sub-Groups ST1, ST1.2, and ST6 presented with severe hyperaemia of the sinusoidal, portal and acinar blood vessels, whilst the hyperaemia of these blood vessels was moderate in Sub-Group ST12. Apelin, BDNF, and cTnI can act as protective factors against negative consequences of stress (e.g., stocking density or heat stress).

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  AtıfScopus5·WoS7·OpenAlex2

  İncele
• MakaleAçık Erişim2018Scopus SJRQ2/r/gumushane/15029
  Obesity in adolescents and the risk factors

  Eker, Hasan Hüseyin; Taşdemir, Mustafa; Mercan, Sümeyye; Mucaz, Meltem; Bektemur, Güven; Sahinoz, Saime; Ozkaya, Emin

  Objectives: This study aims to investigate the frequency of obesity and to identify possible risk factors affecting obesity in adolescents. Materials and methods: This cross-sectional study included a total of 1,357 adolescents between March 2011 and May 2012 in Beyoglu district of Istanbul province of Turkey. The questionnaire including 38 questions which was developed based on the Youth Risk Behavior Survey, which is used by the Center for Disease Control and Prevention (CDC), was used for the data collection. The weight and height of the participants were measured and their body mass index (BMI) values were calculated. Results: Of all participants, 54.8% were females, 5% of them were underweight, 12.6% were overweight, and 2.6% were obese. Among the male participants, the BMI values were higher (21.06±3.32 kg/m2) than females (20.26±2.88 kg/m2) (p<0.0001). The obesity ratio was higher in males (p<0.0001) and in children of highly educated parents (p<0.05). Of the participants, 23.5% were physically active. Physical activity level was higher in males, compared to females (p<0.0001). The rate of breakfast habit was higher in males than females (p=0.002). Healthy diets and losing weight in a healthy way were more commonly accepted by the students in the public schools, compared to those in private schools (p<0.0001). Conclusion: Obesity is an important public health problem and proper eating habits and regular physical activity should be encouraged. High-income families should also encourage their children to become more aware of the importance of physical activity. The right time for this is childhood and adolescence, in which permanent habits can be easily acquired.

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  AtıfScopus17·WoS9·OpenAlex21

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