Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Demir, Selim(7)
- Turan, Ibrahim(7)
- Aliyazicioglu, Yuksel(4)
- Uzun, Sevda(4)
- Özmaya, Esma(3)
- Ayazoglu Demir, Elif(2)
- Aydin, Aydanur(2)
- Bağcivan, Gülcan(2)
- Aliyazicioglu, Rezzan(1)
- Aydın Sayılan, Aylin(1)
- Aytaç, Tufan(1)
- Budak, Burhan(1)
- Demir Doğan, Melike(1)
- Demir, Elif Ayazoglu(1)
- Demir, Sertac Timur(1)
- Demirag, Hatice(1)
- Dogan, Melike Demir(1)
- Ertin, Berkay(1)
- Hintistan, Sevilay(1)
- Kaya, Afşin Ahmet(1)
- Kulakaç, Nurşen(1)
- Kurt, Seda(1)
- Misir, Sema(1)
- Sarikaya, Sevim Beyza Ozturk(1)
- Türkmen, Nihal(1)
- Çilingir, Dilek(1)
- Özgen, Ufuk(1)
- Özkan, Aleyna(1)
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ3Impacts of Phenolic Compounds Alone and in Combination with Natural Substances or Drugs on Cancer Cells
Budak, Burhan; Sarikaya, Sevim Beyza Ozturk
Phenolic compounds (PCs) are secondary metabolites found in the root and flower parts of plants that help protect the plant from pathogens. The amount and content of the plant species and the environment in which they live vary. Because PCs have antioxidant properties, they have a preventive effect against oxidising substances. Therefore, PCs in the human diet contribute to the prevention of cancer, osteoporosis, diabetes, and many other diseases. Cancer is the most dangerous and deadly disease among these diseases today. Although many chemotherapeutic drugs are used against cancer, the tendency to use other drugs or other applications has increased because the effectiveness of chemotherapeutic drugs is low and healthy cells are damaged in the process. PCs boost the effectiveness of chemotherapeutic drugs against cancer cells while, preserving the health of other cells. In this review, in vivo and in vitro studies conducted in cancer lines, applications of PCs alone, combined applications of PCs with natural substances, and the effects of PCs with drugs were investigated and discussed. In conclusion, gallic acid, ellagic acid, caffeic acid, and ferulic acid are frequently used in cancer treatment. These findings highlight the potential of PCs as versatile adjuvants in cancer treatment, which can increase drug efficacy, protect healthy cells, and minimise toxicity. Consequently, they highlight the therapeutic potential of PCs as complementary agents in cancer treatment strategies.
AtıfOpenAlex1İncele - Derleme MakaleYalnız künye2026Scopus SJRQ1Virtual reality as a non-pharmacological adjuvant for anxiety in oncology care: a systematic review and meta-analysis
Aydin, Aydanur; Bağcivan, Gülcan; Özkan, Aleyna
Background: Despite its growing presence in healthcare settings, research on the effectiveness of virtual reality (VR) interventions for symptom experience of patients with cancer remains varied and requires a comprehensive synthesis to reach definitive conclusions. Objective: This systematic review and meta-analysis aimed to assess the effectiveness of VR interventions in managing anxiety among individuals diagnosed with cancer. Methods: A comprehensive search of Ovid MEDLINE, PubMed, CINAHL, Web of Science, and Scopus databases was conducted for studies published from 2000 to November 2025. Publications were evaluated by independent reviewers for inclusion. The methodological quality of the included studies was assessed via Joanna Briggs Institute (JBI) critical appraisal tools for randomized controlled trials and quasi-experimental studies. Results: Twenty-one publications satisfied the requirements for review inclusion. The meta-analysis demonstrated that VR-based interventions were significantly effective in the management of patients’ anxiety, yielding a moderate-to-high effect size (SMD = −0.793, 95% CI = −1.403 to −0.184; Z = −2.551; p = 0.011). Most studies reported statistically significant decreases in anxiety scores across various cancer types, including breast, prostate, and ovarian cancers. No major side effects were reported, although minor instances of cyber sickness were managed by adjusting session durations. User satisfaction was exceptionally high, with satisfaction scores reaching 4.47/5 and 7.35/10. Implications for practice: The results support the use of VR as an effective and safe non-pharmacological intervention for anxiety management. The findings highlight the potential for VR to be integrated into routine oncology nursing and palliative care to improve the patient experience during stressful treatments like chemotherapy. Conclusion: VR-based interventions are an effective, safe, and highly acceptable approach for managing anxiety in patients with cancer. Further research is needed to support wider clinical implementation and to investigate the potential benefits of VR for other physical and psychological symptoms over longer follow-up periods. Trial registration: PROSPERO International Prospective Register of Systematic Reviews CRD42022351573.
- MakaleAçık Erişim2025Scopus SJRQ1Invisible Warriors in the Struggle Against Cancer: Social Support and Spiritual Care—A Phenomenological Study on Patient Experiences †
Özmaya, Esma; Uzun, Sevda
Objective: The aim of this study is to examine the effect of social support on the mental state of cancer patients using a phenomenological approach. Materials–Methods: In this study, a phenomenological research orientation was used, and semi-structured in-depth interviews were conducted with 14 people diagnosed with cancer living in a province in central Turkey. The criterion sampling method, one of the purposeful sampling methods, was used for the sample group. The interviews continued until data saturation was achieved, and all interviews were recorded and later transcribed verbatim. The data were analyzed using thematic analysis, and the study was conducted and reported according to the COREQ checklist. Results: Two categories (effects of cancer and needs of the cancer patient (invisible components)) and five themes (psychological effects, social effects, physical effects, social support, and spiritual care) were identified in the analysis of the data. Conclusions: It has been determined that individuals are affected by cancer mentally, physically, and socially, and have difficulty coping. In particular, it has been found that social support and thinking about the purpose of life, supporting hope, and self-acceptance are quite important in increasing individuals’ spirituality.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ1The Effect of a Mindfulness-Based Stress Reduction Program on Depression and Quality of Life in Cancer Patients
Özmaya, Esma; Uzun, Sevda; Aytaç, Tufan
Mindfulness-based interventions have been receiving growing attention in cancer care. This study was performed to determine the effect of a mindfulness-based stress reduction program on depression and quality of life in cancer patients. The screenings in the study were performed in January to May 2023 through the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Web of Science, Science Direct, and YÖK Thesis Center databases. After the reviews, 14 studies were included in the study. This meta-analysis showed that mindfulness-based stress reduction programs were effective on depression (SMD: −0.363; 95% CI: −0.711 to 0.015; Z = −2.042; P = .041; I2 = 85.229%) and quality of life (SMD: 0.363; 95 CI%: 0.111-0.615; Z = 2.822; P = .005; I2 = 75.222%). The type of cancer (SMD: 0.385; CI: between 0.005 and 0.528; P = .000); duration of therapy (SMD: 0.243; CI: between 0.093 and 0.393; P = .002); the person providing therapy (SMD: 0.335; CI: between 0.133 and 0.507; P = .001); scale used (SMD: 0.290; CI: between 0.148 and 0.432; P = .000); and the origin of the study (SMD: 0.298; CI: between 0.158 and 0.438; P = .000) moderators were found to play a role in the effectiveness of a mindfulness-based stress reduction program on the quality of life of cancer patients. The mindfulness-based stress reduction program yields positive outcomes by reducing depression, enhancing the quality of life in cancer patients, and promoting overall mental well-being in individuals.
AtıfScopus1WoS1İncele - MakaleAçık Erişim2025Scopus SJRQ1Patients' Experiences With Complementary and Alternative Treatments to Manage Chemotherapy Symptoms: A Phenomenological Study
Özmaya, Esma; Uzun, Sevda
This phenomenological study aims to explore the experiences of individuals undergoing chemotherapy, focusing on their symptoms and the use of complementary and alternative treatments to cope with these challenges. Thirteen individuals diagnosed with cancer in a city in the central region of Turkey were interviewed using a semi-structured, in-depth approach in this phenomenological study. The criterion sampling method was employed to select participants, and interviews continued until data saturation was achieved. Thematic analysis was applied to the audio-recorded and transcribed interviews. The study adhered to the COREQ checklist for reporting qualitative research. The data analysis revealed 2 main categories (effects of cancer and chemotherapy on individuals, the use of complementary and alternative treatments to cope with the symptoms of patients receiving chemotherapy) and 6 themes (psychological effects, social impacts, physical effects, social practices, psychological practices, and physical practices). The study demonstrated that individuals faced significant psychological, physical, and social challenges due to cancer, posing difficulties in coping. The symptoms had a substantial negative impact on individuals. The research identified the use of various alternative methods, such as yoga, the Mediterranean diet, and music therapy, as coping strategies. It is recommended that individuals undergoing chemotherapy explore complementary and alternative treatment methods to effectively manage symptoms.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2024Scopus SJRQ2The correlation between individuals' attitudes toward cancer screening, cancer information overload, and healthy life awareness: a cross-sectional study
Dogan, Melike Demir; Kurt, Seda; Ertin, Berkay
AimsThis study was conducted to determine the correlation between individuals' attitudes toward cancer screenings, cancer information overload, and healthy life awareness.MethodsIn this cross-sectional study, data were collected from 343 people through face-to-face interviews using the socio-demographic characteristics form, attitude scale for cancer screenings, cancer information overload scale, and healthy life awareness scale.ResultsThe mean age of the participants was 47.79 +/- 11.65 and 61.8% of them were women. Older participants had lower positive attitudes toward cancer screenings and healthy life awareness. Higher education level participants displayed more positive attitudes toward cancer screenings. The higher the level of education and income, the higher the cancer information overload. When their cancer information overload increased, their positive attitudes toward cancer screenings and their healthy life awareness, in turn, decreased. As their healthy life awareness increased, they displayed more positive attitudes toward cancer screening, as well. As the participants' awareness in change, socialization, responsibility, and nutrition subscales of healthy life awareness scale increased, they had more positive attitudes toward cancer screenings.ConclusionConsequently, it was determined that the participants had a high level of positive attitudes toward cancer screenings, a moderate level of cancer information overload, and a high level of healthy life awareness.
AtıfWoS7OpenAlex9İncele - MakaleAçık Erişim2024Scopus SJRQ2Ethical Dilemmas and Coping Experiences of Nurses Caring for Patients With Hematologic Cancer A Phenomenological Study
Uzun, Sevda
The study aimed to evaluate the ethical dilemmas faced by nurses who provide care to patients with hematologic cancer and determine their coping mechanisms using a phenomenological approach. This qualitative study was conducted with 35 nurses employed in clinics specializing in hematologic cancer patient care, living in diverse regions of Turkey, using semistructured, in-depth interviews through the WhatsApp mobile application. The snowball sampling technique was utilized to identify participants, and interviews continued until data saturation was achieved. All interviews were recorded and subsequently transcribed. Data analysis was conducted using Colaizzi’s phenomenological analysis method, with the study adhering to the COREQ (Consolidated Criteria for Reporting Qualitative Research) checklist for reporting. In the analysis of the data, 2 categories (ethical dilemma situations and coping experiences) and 6 subthemes (treatment, care, professional values and beliefs, emotions, struggling with emotional burdens, and psychosocial approach) emerged. According to the results, nurses responsible for hematologic cancer patients struggle with ethical dilemmas in healthcare delivery and face challenges in effectively addressing them, which could potentially impact the quality of healthcare provided by nurses.
AtıfOpenAlex1İncele - Derleme MakaleAçık Erişim2023Scopus SJRQ3Climate change in Türkiye and its impact on oncology nurses
Kaya, Afşin Ahmet; Aydin, Aydanur; Bağcivan, Gülcan
Climate change threatens human life and health by negatively affecting the basic components of health such as clean air, safe drinking water, nutritious food supply, and safe shelter. Türkiye is a country that is largely exposed to climate change with its cosmopolitan location, which is a bridge between Asia and Europe. Due to climate change, serious effects are seen in all sectors from energy to agriculture, from the economy to health. Climate change is defined as the most important global health threat of the next century, and the problems it brings are seen as the most important pressure factor for the life opportunities of future generations. Food and fresh water availability, rising sea levels, abnormal weather events, migration, and diseases are thought to affect human health. A multidisciplinary approach is required to adapt to climate change’s health effects and reduce its negative health effects. In addition, it is predicted that diseases that are about to disappear will re-emerge and become threats. It is thought that as a result of the contamination of food and water resources with the changing ecosystem, some infections will increase and society will face them. Nurses are both affected by climate change and its effects on public health. Nurses who remain in this situation have a great role in providing effective awareness for raising public awareness. In recent years, oncology clinics have not been affected by fire, earthquakes, and pandemics in our country. In this respect, it can be stated that the health service in Turkish oncology clinics is carried out uninterruptedly and by experts in the field. We learned during the pandemic that the whole world is unprepared for the future effects of climate change. In this direction, nurses should think about solutions for the problems related to climate change in the future.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2021The Effect of Rosa pimpinellifolia Extract on the Proliferation of Human Tumor Cells
Demir, Elif Ayazoglu; Demir, Selim; Türkmen, Nihal; Turan, Ibrahim
The aim of this study was to evaluate the antioxidant properties of R. pimpinellifolia and its cytotoxic effect against human colon (WiDr), liver (HepG2) and lung (A549) cancer cells compared with a normal fibroblast (BJ) cell line. The antioxidant properties of extract was determined using spectrophotometric methods, while the cytotoxic effect of extract was evaluated using MTT assay. The total phenolic content, total flavonoid content and reducing power values of extract were calculated as 16.4 +/- 0.4 mg gallic acid equivalent, 5.2 +/- 0.2 mg quercetin equivalent and 34.3 +/- 2.4 mg trolox equivalent per g sample, respectively. Although the extract exhibits selective cytotoxic effect on three cancer cell lines in a dose-dependent manner compared to BJ cells, the highest selectivity index value (2.7-fold) was obtained for the WiDr cell line. In conclusion, this is the first study to demonstrate the cytotoxic effect of R. pimpinellifolia on cancer cells. To demonstrate the molecular mechanism of this cytotoxic effect and to carry out in vivo studies may be a guide for future clinical studies.
AtıfWoS3OpenAlex5TR Dizin1İncele - MakaleAçık Erişim2021Evaluation of Cytotoxic Effect of Onosma armeniacum Extract on Various Cancer Cells
Demir, Selim; Ayazoglu Demir, Elif; Turan, Ibrahim; Özgen, Ufuk
The aim of this study was to investigate the antioxidant properties of the root extract of Onosma armeniacum and its cytotoxic effect against human liver (HepG2), lung (A549) and colon (WiDr) cancer cell lines compared with a normal fibroblast cell line. Antioxidant properties of the extract was determined using the colorimetric methods. The cytotoxic effect of the extract were investigated using MTT assay. The total phenolic content and reducing power values of extract were 26.1 +/- 0.4 mg gallic acid equivalent and 52.6 +/- 1.1 mg trolox equivalent per g sample, respectively. The extract exhibited selective cytotoxic effect in all studied cancer cell lines, especially HepG2 (3.6-fold). The results of this study reveal that O. armeniacum, which has been found to have acceptable antioxidant and cytotoxic effects, should be examined with more comprehensive studies.
AtıfWoS8OpenAlex12TR Dizin1İncele - MakaleAçık Erişim2021Investigation of the Cytotoxic Effect of Ethyl Pyruvate on Various Cancer Cell Lines
Ayazoglu Demir, Elif; Demir, Selim; Turan, Ibrahim
Ethyl pyruvate (EP) is a simple aliphatic ester derived from pyruvic acid which is an endogenous metabolite. Although various studies have investigated the antioxidant and anti-inflammatory properties of EP, there has been only limited research into the cytotoxic effect of EP on cancer cells. The aim of this study was to determine the cytotoxic effects of EP on cells representing common cancer types. EP was purchased commercially and intermediate stock solutions were prepared with phosphate buffer saline. The cytotoxic effect of EP on human melanoma (VMM917), cervix (HeLa), breast (MCF-7), lung (A549), liver (HepG2), colon (WiDr) cancer and normal fibroblast (BJ) cells was determined using the MTT assay. Cisplatin was used as a positive control in cytotoxicity experiments. The results showed that EP exhibits selective cytotoxic effect on VMM917 (10.1-fold) and HeLa (3.04-fold) cells compared to BJ cells. This study shows for the first time that EP has a highly selective cytotoxic effect, especially on melanoma and cervix cancer cells. The mechanism of this effect needs to be elucidated by more extensive studies.
AtıfWoS2OpenAlex2İncele - MakaleAçık Erişim2021Scopus SJRQ2Relationship of Cachexia with Self-Care Agency and Quality of Life in Cancer Patients: The Case of Turkey
Demirag, Hatice; Kulakaç, Nurşen; Hintistan, Sevilay; Çilingir, Dilek
Objective: This study aims to determine the effects of cachexia, causing major problems in the world and Turkey, on self-care agency and quality of life in cancer patients. Methods: The population of this cross-sectional and relationship-seeking study consisted of cancer patients in Turkey from April 1 to April 20, 2021. Using the snowball sampling method, 174 patients were sampled. 'Patient Information Form,' 'The European Organization for Research and Treatment of Cancer C30 Cancer Quality of Life Scale,' and 'Exercise of Self-Care Agency Scale' were used as data collection tools. Results: In the study, 52 patients (29.9%) were found to have cachexia. Function, general well-being, symptom (except insomnia), and self-care agency, which are subdimensions of the quality-of-life scale, were found to be significantly lower in patients with cachexia than patients without cachexia (P < 0.001). It was determined that there was a significant negative correlation between the cachexia status of the patients and the five basic functions in the functional scale (physical, role, emotional, cognitive, and social function), general well-being, and self-care agency, and there was a significant positive correlation between the cachexia status of the patients and the symptom scale (P < 0.001). According to the results of multiple linear regression analysis, it was found that the factor that significantly affected the cachexia status of the patients was their self-care agency (P < 0.001). Conclusions: It was determined that cachexia caused significantly lower self-care agency and quality of life in cancer patients. Furthermore, quality of life was related to self-care agency.
AtıfScopus5WoS6OpenAlex6İncele - MakaleAçık Erişim2020Scopus SJRQ2Illness perception, perceived social support and quality of life in patients with diagnosis of cancer
Aydın Sayılan, Aylin; Demir Doğan, Melike
Introduction: Research has shown that social support has a significant impact on quality of life. The purpose of this cross-sectional study was to determine the relationship between perceived social support, perception of disease and quality of life, and the factors affecting these, in patients with cancer in Turkey. Methods: The study data were collected from two hospitals. Data were collected using the face-to-face interview method from patients diagnosed with cancer between March and August 2018. No sampling was performed, and the entire population was studied. Results: The mean age of the patients in the study was 61.37 ± 14.89 years. Married patients had better social support than single individuals (t = 2.129; p = 0.035). Significant negative correlation was found between the illness perception scale and total quality of life scale score (r = −0.163; p = 0.026), and physical well-being (r = −0.224; p = 0.002) and social well-being (r = −0.199; p = 0.006) subscales. Conclusion: Patients’ social support and quality of life were at moderate levels. Married participants had better social support than single participants, and operated participants had better social support than unoperated participants. As illness perception decreased, quality of life, physical well-being and social well-being increased.
AtıfScopus51WoS42OpenAlex43İncele - MakaleAçık Erişim2019Selective Cytotoxic Effect of Dorycnium pentaphyllum Extract on Human Breast, Liver, and Lung Cancer Cells
Demir, Selim; Turan, Ibrahim; Misir, Sema; Aliyazicioglu, Yuksel
Although some studies have evaluated the cytotoxic activity of different Fabaceae species, there has been only limited research into the cytotoxic effect of Dorycnium pentaphyllum. The purpose of this study was to determine the antioxidant properties and cytotoxic effect of D. pentaphyllum extract on various human cancer cells. The total phenolic content (TPC) of the extract was determined using colorimetric method. The cytotoxic effect of the extract on human lung (A549), liver (HepG2), and breast (MCF-7) cancer cells and a normal human fibroblast cells was assessed using the MTT assay. TPC value of extract was found as 140.3 +/- 1.1 mg gallic acid equivalent per g sample. Extract showed selective cytotoxicity on all studied cancer cells compared to normal fibroblast cells, and the IC50 values of the extract in the cancer cells range from 100.4 to 298.5 mu g/mL. This is the first study to reveal the cytotoxic effect of D. pentaphyllum extract on cancer cell lines. Phytomedical applications of D. pentaphyllum may represent promising approaches in the treatment of cancer.
AtıfWoS7OpenAlex7TR Dizin5İncele - MakaleAçık Erişim2019Antioxidant Properties of Primula vulgaris Flower Extract and Its Cytotoxic Effect on Human Cancer Cell Lines
Demir, Selim; Turan, Ibrahim; Aliyazicioglu, Yuksel
Primula vulgaris is a plant belonging to Primula genus, and these species are often used in traditional therapy. Although there are numerous studies on the antioxidant and cytotoxic effects of different Primula species, there are limited studies of these properties of P. vulgaris extracts. The aim of this study was to determine the antioxidant properties and cytotoxic effects of the extract prepared with dimethyl sulfoxide from P. vulgaris flowers. The total phenolic content, total flavonoid content, and reducing antioxidant power of the extract were determined using spectrophotometric methods. The cytotoxic effect of the extract on human colon (WiDr), lung (A549), liver (HepG2), breast (MCF-7), and prostate (PC-3) cancer cells and a normal human fibroblast cell line was assessed using the MTT assay. Total phenolic content and reducing power values of extract were found 33.02 +/- 0.92 mg gallic acid equivalents, and 64.86 +/- 1.18 mg trolox equivalents per g sample, respectively. Extract exhibited selective cytotoxic effect on all studied cancer cells compared to normal fibroblast cells, and the IC50 values of the extract in the cancer cell lines range from 191.8 to 375.3 mu g/mL. This work is one of the pioneering work that reveals the powerful antioxidant properties of P. vulgaris flower extract and its selective cytotoxic effect on cancer cell lines. Further studies are needed to identify the active molecules in the extract and the cytotoxic action mechanisms of these molecules.
AtıfWoS20OpenAlex22TR Dizin9İncele - MakaleAçık Erişim2018Cytotoxic Effect of Rhododendron luteum Leaf Extract on Human Cancer Cell Lines
Demir, Selim; Turan, Ibrahim; Aliyazicioglu, Yuksel
Rhododendron luteum belongs to the genus Rhododendron, members of which are frequently used in folk medicine. Various studies have investigated the cytotoxic effect of different Rhododendron species, but there have been limited studies of the cytotoxic effect of R. luteum. The aim of this study was to investigate the antioxidant properties and cytotoxic effect of R. luteum leaf extract on the human cancer cells. The total phenolic content (TPC), total flavonoid content (TFC), and reducing power of the extract were evaluated using spectrophotometric procedures. The cytotoxic effect of the extract on five cancers (human breast, colon, lung, prostate, and liver carcinoma) and human fibroblast cells was determined using the MTT assay. TPC and reducing power values of extract were found 173.2 +/- 3.97 mg gallic acid equivalents, and 629.5 +/- 3.49 mg trolox equivalents per g sample, respectively. R. luteum leaf extract exhibited selective cytotoxicity especially against colon (1.9 fold) and liver (2.2 fold) cancer cells compared to normal fibroblast cells. This is the first study to reveal the cytotoxic effect of R. luteum leaf extract. Further studies are now needed to identify the cytotoxic molecules in the extract and their mechanisms.
AtıfWoS15İncele - MakaleAçık Erişim2017Evaluation of Antioxidant and Cytotoxic Properties of Primula vulgaris Leaf Extract
Turan, Ibrahim; Demir, Selim; Aliyazicioglu, Rezzan; Aliyazicioglu, Yuksel
Primula vulgaris belongs to the genus Primula and this genus is frequently used in traditional medicine. Numerous studies reported the antioxidant and cytotoxic effects of various extracts of different Primula species but, there were limited studies of the antioxidant and cytotoxic effect of P. vulgaris. The aim of this study was to determine the antioxidant properties and cytotoxic effects of dimethyl sulfoxide extract of leaves of P. vulgaris. The total polyphenolic content (TPC), total flavonoid content (TFC) and reducing antioxidant power of extract were evaluated using spectrophotometric procedures. The cytotoxic effects of extract were revealed on human lung (A549), liver (HepG2), breast (MCF-7), prostate (PC-3), and colon (WiDr) cancer cell lines and normal fibroblast cells using thiazolyl blue tetrazolium bromide (MTT) assay. TPC and FRAP values were 1890.1 +/- 11.2 mg gallic acid equivalents and 3233.1 +/- 176.2 mg trolox equivalents per 100 g sample, respectively. The extract showed selective cytotoxic effects on all studied cancer cell lines compared to normal fibroblast cells and IC50 values ranged from 133.3-253.8 mu g/mL. This is the first study to reveal the antioxidant properties of P. vulgaris leaf extract and its cytotoxic effect on cancer cell lines. Further studies are now needed to identify the antioxidant and cytotoxic molecules in the extract and their mechanisms.
AtıfWoS15OpenAlex6İncele - MakaleYalnız künye2016Disease and Death in the Modern Culture: On Now and Eternity
Demir, Sertac Timur
This paper is basically about nowism as a representation of modernity rather than a temporal fragment, about cancer as philosophical reference rather than as a biological illness, and about death as constructive value rather than as a destructive experience. All these representation-loaded concepts are dealt with through the story of Tessa, the protagonist in the film Now is Good (2012). In the liquid modernity, on the one hand nowist orientations, tendencies and acts are wryly reduced to a cliche: Carpe diem (seize the day) and on the other hand temporal uncertainty of death implies the essential principle of memento mori (remember you will die) or Mutu qabla an tamutu (die before you die). The now is, as a worldview beyond a temporality, not merely good, but perhaps the God of the modern society. However, deadly cancer, which is an uninvited guest, nullifies this modern doctrine that commercializes the now as eternity and immortality itself. Cancer that marks death and the sense of chaos what cancer stirs are antithesis and perhaps antidote of the liquid modernity. This paper, for the very reason, unexpectedly affirms death while criticising the nowist culture.
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