Gümüşhane ÜniversitesiGümüşhane ÜniversitesiAçık Erişim Arşivi · RDL Open

Evaluation of Cytotoxic Effect of Onosma armeniacum Extract on Various Cancer Cells

MakaleAçık Erişim
  • SDG 3 · Sağlık ve Kaliteli Yaşam

Özet

The aim of this study was to investigate the antioxidant properties of the root extract of Onosma armeniacum and its cytotoxic effect against human liver (HepG2), lung (A549) and colon (WiDr) cancer cell lines compared with a normal fibroblast cell line. Antioxidant properties of the extract was determined using the colorimetric methods. The cytotoxic effect of the extract were investigated using MTT assay. The total phenolic content and reducing power values of extract were 26.1 +/- 0.4 mg gallic acid equivalent and 52.6 +/- 1.1 mg trolox equivalent per g sample, respectively. The extract exhibited selective cytotoxic effect in all studied cancer cell lines, especially HepG2 (3.6-fold). The results of this study reveal that O. armeniacum, which has been found to have acceptable antioxidant and cytotoxic effects, should be examined with more comprehensive studies.

Anahtar Kelimeler

Antioxidant activityCancerCell cultureCytotoxicityOnosma armeniacum
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/gumushane/16277Resmi atıflarda kullanılan kalıcı adres
Atıflar
WoS
8
OpenAlex
12
TR Dizin
1
Her kaynağın kendi saydığı toplam atıf; aktarım ve zenginleştirme sırasında alındı.
Tam Kayıt
AlanDeğerDil
dc.contributor.authorDemir, Selim
dc.contributor.authorAyazoglu Demir, Elif
dc.contributor.authorTuran, Ibrahim
dc.contributor.authorÖzgen, Ufuk
dc.date.accessioned2026-10-22T10:29:09.967127322Z
dc.date.available2026-10-22T10:29:09.967127322Z
dc.date.issued2021
dc.description.abstractThe aim of this study was to investigate the antioxidant properties of the root extract of Onosma armeniacum and its cytotoxic effect against human liver (HepG2), lung (A549) and colon (WiDr) cancer cell lines compared with a normal fibroblast cell line. Antioxidant properties of the extract was determined using the colorimetric methods. The cytotoxic effect of the extract were investigated using MTT assay. The total phenolic content and reducing power values of extract were 26.1 +/- 0.4 mg gallic acid equivalent and 52.6 +/- 1.1 mg trolox equivalent per g sample, respectively. The extract exhibited selective cytotoxic effect in all studied cancer cell lines, especially HepG2 (3.6-fold). The results of this study reveal that O. armeniacum, which has been found to have acceptable antioxidant and cytotoxic effects, should be examined with more comprehensive studies.
dc.identifier.doi10.18016/ksutarimdoga.vi.729814
dc.identifier.eissn2619-9149
dc.identifier.endpage259
dc.identifier.issue2
dc.identifier.startpage252
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/gumushane/16277
dc.identifier.volume24
dc.identifier.wosWOS:000639677000001
dc.language.isoen
dc.publisherKAHRAMANMARAS SUTCU IMAM UNIV REKTORLUGU
dc.relation.ispartofKSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidant activity
dc.subjectCancer
dc.subjectCell culture
dc.subjectCytotoxicity
dc.subjectOnosma armeniacum
dc.subject.classificationAgriculture, Multidisciplinary
dc.subject.classificationAgriculture
dc.subject.otherRADICAL-SCAVENGING ACTIVITY
dc.subject.otherDORYCNIUM-PENTAPHYLLUM
dc.subject.otherPHYTOCHEMICAL ANALYSIS
dc.subject.otherANTIOXIDANT PROPERTIES
dc.subject.otherTURKISH PROPOLIS
dc.subject.otherCYCLE ARREST
dc.subject.otherNAPHTHOQUINONES
dc.subject.otherANTIBACTERIAL
dc.subject.otherAPOPTOSIS
dc.subject.otherBREAST
dc.titleEvaluation of Cytotoxic Effect of Onosma armeniacum Extract on Various Cancer Cells
dc.typeArticle
dspace.entity.typePublication
rdl.citation.openalex12
rdl.citation.trdizin1
rdl.citation.wos8
rdl.oa.statusgold
rdl.oa.urlhttp://dogadergi.ksu.edu.tr/en/download/article-file/1079772
rdl.sdgSDG03
rdl.source.indexWOS
rdl.source.indexTRDIZIN
rdl.wos.indexEmerging Sources Citation Index (ESCI)