When Should Antibiotic Prophylaxis Be Performed to Prevent Surgical Side Infections? A Systematic Review

The systematic review was planned to examine the application time of antibiotic prophylaxis to prevent surgical side infections. The keywords, “antibiotic application time”, “antibiotic prophylaxis” and “surgical side infections”, were searched both in Turkish and English in Google Scholar, PUBMED, and EBSCO databases. A total of 5969 studies published between 2009 and 2019 were screened. After the literature review, 5 related studies that met the inclusion criteria were included in the study. Preoperative antibiotic prophylaxis and antibiotic application times were examined. In a study included in the study, it was shown that the risk of developing surgical site infection was reduced in patients who received antibiotics for proclactic purposes 60 minutes before incision line formation. In the remaining four studies, it was stated that prophylactic antibiotherapy applied 30 minutes before surgery minimizes the development of surgical site infection. It was revealed that the application of prophylactic antibiotherapy 30 minutes before the incision line minimizes the risk of infection in the surgical area and the literature should be supported by studies on the time of antibiotic administration.