The Effect of Jet Lidocaine on Pain and Anxiety During Peripheral Venous Access: A Systematic Review and Meta-Analysis

Objective: – The aim of this study was to determine the effect of jet lidocaine on pain and anxiety during peripheral venous access. Methods: – A comprehensive literature search was conducted in PubMed, Web of Science, EBSCOhost, Google Scholar, and the YÖK Thesis Center without year limitation. Five randomized controlled trials that met the inclusion criteria were included in the analysis. Data extraction and methodological quality assessment were performed using the Joanna Briggs Institute (JBI) Critical Appraisal Tools, and study selection was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. The findings were synthesized using meta-analysis and narrative synthesis. Results: – The pooled analysis demonstrated that jet lidocaine significantly reduced anxiety related to peripheral venous access (standardized mean difference: −1.031; 95% confidence interval: −1.653 to −0.409; Z = −3.249; P =.001; I2 = 89.98%). However, its effect on pain was not statistically significant (standardized mean difference: −0.817; 95% confidence interval: −1.817 to 0.182; Z = −1.602; P =.109; I2 = 96.57%). Conclusion: – Jet lidocaine may be an effective option for reducing anxiety during peripheral venous access; however, its effect on pain was not statistically significant. Further high-quality randomized controlled trials with standardized protocols and larger sample sizes are needed to clarify its analgesic effectiveness and clinical outcomes.