Sürdürülebilir Kalkınma Amaçları

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Alt birimler

• Eczane Hizmetleri Bölümü
• Terapi ve Rehabilitasyon Bölümü
• Tıbbi Hizmetler ve Teknikler Bölümü

Araştırmacılar(18)

• Aydın, Fatma
• Bahar, Betül
• Balcı, Neslihan
• Duran, Secil
• Kaya, Kübra
• Özen, Derya Öztürk
• Palaz, İlknur
• Perçin, Alper
• Sarı, Emre
• Tas, Ahmet
• Taş, Muhammed Üsame
• Tekin, Hatice
• Tuna, Merve
• Turhan, Esra Seda
• Türkel, Nagihan
• Varan, Emre
• Yalçınkaya, Dilek
• Yıldırım, Emrullah

• MakaleAçık Erişim2026/r/gumushane/16775
  INVESTIGATION OF THE EFFECT OF INSTRUMENT-ASSISTED SOFT TISSUE MOBILIZATION IN INDIVIDUALS WITH LUMBAR DISC HERNIATION: A RANDOMIZED CLINICAL TRIAL

  Tas, Muhammed Usame; Usgu, Gunseli

  Purpose: This research evaluated the effects of the instrument-assisted soft tissue mobilization (IASTM) technique in individuals with lumbar disc herniation (LDH). Methods: Forty LDH patients were randomly assigned to a control group or an IASTM group (20 patients in each group). The IASTM group underwent a treatment protocol consisting of two IASTM sessions per week in addition to classic physiotherapy methods (hotpack, transcutaneous electrical nerve stimulation, ultrasound and exercise) over a four week period. The treatment specifically targeted the paraspinal muscles, gluteus maximus, gluteus medius and hamstring muscles. All participants were assessed before treatment, immediately after treatment and two months post-treatment using various measures, including pain intensity visual analog scale, straight leg raise (SLR) test, slump test (measuring knee extension from 90 degrees flexion), 6-minute walking test (6-MWT), range of motion (ROM) and the Short Form-36 (SF-36) questionnaire. Results: Both groups experienced a significant decrease in pain immediately after treatment (p=0.002). However, although both groups showed improvements in post-treatment SLR, slump test, 6-MWT, ROM, and SF-36 scores, no significant correlations were found (p=0.208). However, the IASTM group experienced greaterclinical improvement across all parameters. Conclusion: The findings suggest that incorporating IASTM techniques into physiotherapy programs for individuals with LDH can enhance rehabilitation outcomes.

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• MakaleAçık Erişim2026/r/gumushane/19431
  Attitudes Toward Artificial Intelligence Among Physiotherapy and Rehabilitation Students: A Cross-Sectional Study

  Candiri, Büşra; Yılmaz, Ramazan Cihad; Perçin, Alper; Karaoba, Dilan Demirtaş

  Purpose: The aim of this study was to investigate the attitudes of Physiotherapy and Rehabilitation students towards Artificial Intelligence (AI) and to compare the attitudes towards AI according to sociodemographic variable. Methods: 212 students participated in this study. Participants’demographic data were recorded using a sociodemographic data form. Students’ attitudes toward AI were surveyed with the General Attitudes toward Artificial Intelligence Scale (GAAIS). This study was designed as a cross-sectional study. Results: Positive attitude scores differed significantly according to daily internet use duration (Kruskal–Wallis H = 17.934, p = 0.001), with higher scores observed among students using the internet more than four hours per day (47.04 ± 7.83). Negative attitude scores differed significantly by accommodation type (ANOVA F = 2.26, p = 0.003) and source of scholarship income (Kruskal–Wallis H = 2.772, p = 0.028). No significant differences were found according to age, gender, class level, type of high school graduated, perceived income status, and parental education level (p > 0.05). Conclusion: Students had positive attitudes toward AI. Moreover, while students’ attitudes were not affected by sociodemographic variables. However, greater use of the internet and AI was associated with more positive attitudes.

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• MakaleAçık Erişim2025/r/gumushane/19576
  Examination of awareness, knowledge and beliefs on pelvic floor and pelvic floor muscle training in pregnant women

  Ankarali, Handan; Özengin, Nuriye; Bakar, Yesim; Topcuoglu, Mehmet Ata; Bahar, Betül

  Aim: This study aimed to determine the awareness, knowledge, and beliefs of pregnant women on pelvic floor and pelvic floor muscle training. Methods: A total of 250 volunteer women with gestational weeks ranging between 5 to 40 weeks were included in this study. After the physical and socio-demographic characteristics of the pregnant women were recorded, they were asked to complete the questionnaire assessing their awareness, knowledge and beliefs on pelvic floor and pelvic floor muscle training. Results: It was determined that 70.4% of the pregnant women had not heard of the pelvic floor muscles before, 95.2% did not get information about pelvic floor muscles, 90.8% did not know why they needed pelvic floor muscles. It was found that 47.6% of the pregnant women believed that urinary incontinence during pregnancy was normal. In addition, 98% of the pregnant women did not think that they had sufficient information about pelvic floor muscles. It was found that knowledge, awareness and beliefs about pelvic floor and pelvic floor muscles were similar between gestational trimesters (p> 0.05). Conclusion: As a result, pregnant women had insufficient awareness and knowledge levels, maladaptive beliefs about pelvic floor muscles and training. It is essential for pregnant women to know potential problems, preventive and therapeutic methods in this process which they are at risk for various pelvic floor dysfunctions. Therefore, it can be recommended that pregnant women should be routinely informed about the pelvic floor by health professionals and encouraged to participate in pelvic floor muscle training.

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• MakaleAçık Erişim2025/r/gumushane/16059
  An Investigation into the Impact of Influencers Producing Technological Content on Instagram on Customers' Purchasing Decisions

  Çelik, Kamil; Tas, Ahmet

  Nowadays, social media influencers play a significant role in the world of marketing. Social media influencers reach large audiences by producing content on social media platforms, and they exert considerable impact on these audiences. The literature suggests that social media users form parasocial relationships, and these relationships develop based on the influencer's characteristics, such as attractiveness, expertise, credibility, and similarity. It has also been proven in various studies that social media influencers have a strong effect on increasing the purchasing intentions of their followers. In this study, the effects of social media influencers on parasocial relationships and the purchasing intentions of their followers were examined. The research was conducted among Instagram users in Turkey, and the data were collected using a survey method. The survey included statements aimed at measuring elements such as parasocial relationships, attractiveness, expertise, credibility, and similarity. Because of the data analysis, it was found that characteristics such as influencers' attractiveness and expertise strengthen parasocial relationships, and these relationships positively influence followers' purchasing intentions. Additionally, the perception of fairness also had a significant impact on these relationships. These findings suggest that social media influencers can be an effective tool in marketing strategies.

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• MakaleYalnız künye2025/r/gumushane/13533
  Inhibition Effect of Cordyceps sinensis (C. sinensis) Mycelium on Some Metabolic Enzymes and Investigation of Antioxidant Properties

  Balcı, Neslihan

  Cordyceps sinensis (CS), a traditional medicinal fungus, is a rich source of bioactive metabolites with pharmacological potential. This study investigated the inhibitory effects of CS mycelium on human carbonic anhydrase isoenzymes I and II (hCA I and hCA II) and acetylcholinesterase (AChE), as well as its antioxidant properties. Enzyme inhibition was assessed using spectrophotometric methods, whereas antioxidant capacity was evaluated by DPPH, ABTS, CUPRAC, FRAP, and Fe3⁺-reducing assays. LC-MS/MS analysis identified key secondary metabolites, including apigenin, apigenin-7-glucoside, (+)-taxifolin, dihydrokaempferol, p-coumaric acid, salicylic acid, and L-theanine, with apigenin as the major constituent. CS strongly inhibited hCA I (IC50 = 1.11 µg/mL) and hCA II (IC50 = 1.77 µg/mL), exceeding the potency of acetazolamide, and also showed relevant AChE inhibition (IC50 = 8.00 µg/mL), comparable to tacrine. Antioxidant assays revealed moderate DPPH activity but strong ABTS and CUPRAC reducing capacities, indicating the structural contributions of flavonoids and phenolic acids. These findings suggest that CS possess dual bioactivity through enzyme inhibition and antioxidant effects, highlighting its therapeutic potential against neurodegenerative and oxidative stress–related diseases.

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• MakaleAçık Erişim2025/r/gumushane/12426
  Evaluation of Antioxidant and Enzyme Inhibition Properties of Siran Propolis: Correlations With Phenolic Content Determined by LC–MS/MS

  Balci, Neslihan; Aslan, Kubra; Erturk, Adem; Gulcin, Ilhami

  This study evaluates the antioxidant activity, enzyme inhibition potential, and phenolic composition of ethanolic Siran propolis extract. Antioxidant capacity was measured using reducing power (CUPRAC, FRAP, and Fe3+-reducing) and radical scavenging (DPPH·, ABTS·+, and DMPD·+) assays. The extract showed strong reducing ability, surpassing standard antioxidants in CUPRAC and FRAP assays, correlating with high ferulic acid (40.40 mg/g) and p-coumaric acid (88.60 mg/g) levels identified by LC–MS/MS. While it demonstrated notable DPPH· scavenging (IC50: 30.14 μg/mL), ABTS·+ activity was weaker (IC50: 272.44 μg/mL). Enzyme inhibition assays indicated effective inhibition of α-glycosidase, AChE (IC50: 2.15 μg/mL), hCA I, and hCA II. Notably, AChE inhibition was stronger than the standard tacrine inhibitor (IC50: 8.82 μg/mL), suggesting neuroprotective potential. The observed bioactivities are attributed to synergistic effects of phenolic acids and flavonoids, including quercetin, luteolin, taxifolin, and resveratrol. These findings highlight Siran propolis as a promising natural antioxidant and enzyme inhibitor source with potential therapeutic applications and food formulations.

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• MakaleAçık Erişim2025/r/gumushane/12209
  Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs

  Öztürk, Cansu; Balci, Neslihan; Aslan, Osman Nuri; Kalay, Erbay

  Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects millions of individuals worldwide. Treatment strategies for AD vary depending on cognitive and behavioral symptoms, with cholinergic replacement therapy using acetylcholinesterase (AChE) inhibitors being one of the primary approaches. Recent studies have also identified human carbonic anhydrases (hCAs) as significant therapeutic targets for AD, offering new opportunities for the development of innovative treatments. Carbonic anhydrase inhibitors have been shown to prevent early mitochondrial damage and inhibit H2O2 production, thereby reducing amyloid plaque formation. Building on the promising potential of hydrazones particularly sulfonyl hydrazones as anticholinesterase agents, we synthesized 12 novel chlorine-substituted sulfonyl hydrazone compounds containing aryl sulfonate ester groups. These compounds were evaluated for their inhibitory effects on AChE, hCA I, and hCA II enzymes. The synthesized compounds exhibited low nanomolar inhibitory activity, with Ki values ranging from 9.58 ± 2.22 to 104.04 ± 23.82 nM for AChE, 9.12 ± 2.21 to 477.63 ± 218.52 nM for hCA I, and 17.54 ± 7.74 to 564.62 ± 213.98 nM for hCA II. Notably, compound 6 showed strong inhibitory activity against hCA I (Ki = 9.12 ± 2.21 nM; acetazolamide (AZA) = 26.54 ± 3.11 nM) and hCA II (Ki = 17.54 ± 7.74 nM; AZA = 21.73 ± 2.42 nM), whereas compound 4 exhibited superior AChE inhibition (Ki = 9.58 ± 2.22 nM; TAC = 23.12 ± 2.05 nM). The chemical structures of the synthesized compounds were characterized using advanced spectroscopic techniques, including FT-IR, 1H-NMR, and 13C-NMR spectroscopy.

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• MakaleAçık Erişim2025/r/gumushane/11776
  Psychometric evaluation and cultural adaptation of the Turkish version of the needs assessment tool: progressive disease-heart failure (NAT: PD-HF)

  Kiliç, Betülay; Palaz, Ilknur; Gürel, Tugba Yardimci

  Heart failure (HF) is a progressive, life-limiting condition that often leads to complex physical, emotional, and social needs. This study aimed to translate, culturally adapt, and validate the Turkish version of the Needs Assessment Tool: Progressive Disease-Heart Failure (NAT: PD-HF) to facilitate the timely identification of palliative care needs. A total of 98 patients with chronic HF, 91 caregivers, and 25 healthcare professionals participated in this single-centre validation study. The tool underwent forward-backward translation and pilot testing. Internal consistency was good (Cronbach’s α = 0.812), and inter-rater and test-retest reliabilities were high (PABAK: 0.908–1.000). Most patients (84.7%) found the tool understandable, and 67.7% felt it enhanced care. Healthcare professionals from cardiology, intensive care, and palliative care rated it as clinically relevant and feasible. The Turkish NAT: PD-HF is a valid, reliable, and culturally appropriate tool for identifying the palliative care needs of patients with HF and their caregivers. This tool can be integrated into routine clinical practice to facilitate early identification of palliative care needs.

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• MakaleAçık Erişim2025/r/gumushane/11585
  Inhibition Effect of Diosmin Flavanoid on Some Metabolic Enzymes and Investigation of Antioxidant Properties

  Balci, Neslihan

  Diosmin is a natural flavonoid obtained by dehydrating flavanone glycoside hesperidin. This study evaluated the inhibition effects of diosmin flavonoid on human carbonic anhydrases (hCA I and hCA II) and acetylcholinesterase (AChE) enzymes, which are linked to various health issues, and compared the results with standard drugs. The antioxidant potential was assessed using five assays, namely DPPH, ABTS, FRAP, CUPRAC and Fe3+ reducing assays. The results determined that diosmin didn’t exhibit strong antioxidant activity. Additionally, the inhibition effects of diosmin on hCA I, hCA II, and AChE enzymes were examined. It effectively inhibited hCA I and hCA II enzymes with Ki values of 3.84±0.63 nM and 15.64±1.90 nM, respectively (Table 1). For comparison, the Ki values of the standard drug AZA were 1.44 ± 0.32 nM for hCA I and 3.66 ± 0.25 nM for hCA II. On the other hand, diosmin effectively inhibited AChE enzymes with Ki values of 9.31±2.40 nM. The Ki values of the standard drug Tacrine was 6.22±1.95 nM for AChE. These findings suggest that diosmin may serve as a selective enzyme inhibitor, particularly for hCA I, but has limited antioxidant capacity. Diosmin exhibited relatively weak antioxidant activity compared to standard antioxidants.

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• MakaleYalnız künye2024/r/gumushane/19872
  Examination of The Relationship Between Consumers' Digital Footprint Awareness and Their Decision-Making Styles in Digital Marketing With The Structural Equality Model

  Taş, Ahmet; Bulbul, Halil Ibrahim

  The integration of digital technology with the internet has brought up various subjects and concepts. Individuals using the Internet create their digital footprints with their activities in the digital environment. With the help of digital footprint, political views, personality traits, potential beliefs, etc. can be predicted. This study was prepared to determine the level of impact of individuals' digital footprint awareness on their decision-making style when purchasing products online. The data were collected through an online survey and analyzed using SPSS and AMOS programs. The sample of the study included 607 individuals from different groups, and after eliminating outliers at the structural equation model stage, data from 461 participants were analyzed. As a result of the analysis, it was seen that participants were aware that their activities on the internet environment could affect them, they made decisions as they wished, some sub-dimensions had differences between genders, and generally there was no difference in demographic characteristics in terms of digital footprint awareness. Additionally, an analysis of demographic variables showed that there was a relationship between conscious awareness and digital footprint, and some sub-dimensions of consumer decision-making style and digital footprint.

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