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- MakaleYayıncıda açık erişim2014The evaluation of mean platelet volume levels in patients with primary and secondary Raynaud's Phenomenon
Memetoglu, Mehmet Erdem; Kutlu, Rasim; Memetoglu, Ozge Gulsum; Kehlibar, Tamer; Yilmaz, Mehmet; Günay, Rafet; Ketenci, Bulend; Güney, Mehmet Rasit; Demirtas, Mahmut Murat; Özel, Deniz
Background - Mean platelet volume (MPV) is an indicator of platelet activation. The pathophysiology of the primary and secondary Raynaud's Phenomenon (RP) have not been completely established. The aim of this study was to investigate the relationship between MPV and RP. Materials and Methods - Our study was a prospective randomized study carried out from January 2011 to March 2012. The study group consisted of 39 patients: 27 (70%) patients having primary, 12 (30%) patients having secondary RP. An age-, gender-, and body mass index-matched control group consisted of 40 healthy participants. We compared the MPV in patients with RP and control participants statistically. Results - MPV of RP group was 8.79 +/- 1.37 femtoliter (fL) while MPV of control group was 8.39 +/- 1.36 fL. Comparison of MPV of RP group and control group showed no difference (p = 0.274). The mean of MPV was significantly higher among patients with secondary RP (9.76 +/- 1.68 fl) when compared with patients with primary RP (8.37 +/- 0.96 fl) (p = 0.018). Conclusion - The results of our study suggest that MPV may be used as a marker in secondary RP.
- MakaleAçık Erişim2012Is Increased Mean Platelet Volume a Risk Factor in Patients with Acute Deep Vein Thrombosis?
Kalkan, Asim; Memetoglu, Mehmet Erdem; Bilir, Ozlem; Ersunan, Gokhan; Kutlu, Rasim; Tutar, Nuri
Objectives The purpose of this retrospective study was to compare the mean platelet volume between the patients with acute deep vein thrombosis (DVT) and control subjects. Methods Data were collected retrospectively from the patients' medical records. The study group consisted of 110 patients with newly diagnosed acute DVT in the lower extremities. An age, gender, and body mass index-matched control group consisted of 98 patients with normal duplex ultrasound findings. We compared the mean platelet volume in patients with acute DVT and control participants. Results There was no significant difference between the study and control groups in mean platelet volume (8.8 +/- 1.6 vs 8.7 +/- 1.3 fl, respectively; p>0.05). Age (p=0.899), body mass index (p=0.43), gender (p=0.466), and platelet count (p=0.886) were statistically similar in both groups. Conclusions There was no significant difference in mean platelet volume between patients with acute DVT and the control group. According to our result, we propose that mean platelet volume should not be considered as an index of acute DVT.
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