Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleYayıncıda açık erişim2014The evaluation of mean platelet volume levels in patients with primary and secondary Raynaud's Phenomenon
Memetoglu, Mehmet Erdem; Kutlu, Rasim; Memetoglu, Ozge Gulsum; Kehlibar, Tamer; Yilmaz, Mehmet; Günay, Rafet; Ketenci, Bulend; Güney, Mehmet Rasit; Demirtas, Mahmut Murat; Özel, Deniz
Background - Mean platelet volume (MPV) is an indicator of platelet activation. The pathophysiology of the primary and secondary Raynaud's Phenomenon (RP) have not been completely established. The aim of this study was to investigate the relationship between MPV and RP. Materials and Methods - Our study was a prospective randomized study carried out from January 2011 to March 2012. The study group consisted of 39 patients: 27 (70%) patients having primary, 12 (30%) patients having secondary RP. An age-, gender-, and body mass index-matched control group consisted of 40 healthy participants. We compared the MPV in patients with RP and control participants statistically. Results - MPV of RP group was 8.79 +/- 1.37 femtoliter (fL) while MPV of control group was 8.39 +/- 1.36 fL. Comparison of MPV of RP group and control group showed no difference (p = 0.274). The mean of MPV was significantly higher among patients with secondary RP (9.76 +/- 1.68 fl) when compared with patients with primary RP (8.37 +/- 0.96 fl) (p = 0.018). Conclusion - The results of our study suggest that MPV may be used as a marker in secondary RP.
- MakaleYalnız künye2014Relationship between platelet indices and international normalized ratio in patients with non-valvular atrial fibrillation
Arik, Osman Ziya; Özkan, Bugra; Kutlu, Rasim; Karal, Huseyin; Sahin, Durmus Yildiray; Kaypakli, Onur; Özel, Deniz; Çayil, Murat
Atrial fibrillation (AF) is the most common sustained arrhythmia and associated with adverse outcomes and increased risk for thromboembolic events. Warfarin is still the most extensively prescribed oral anticoagulant in AF to prevent ischemic complications. We aimed to determine the differences at platelet indices with warfarin usage layered by International Normalized Ratio (INR). A total of 250 patients with permanent non-valvular AF (mean age 70.2 +/- 9.1; 153 female) were divided into two groups. Group 1 included 125 patients whose INR is between 2.0 and 3.0 (called as effective'') and Group 2 included 125 patients whose INR is <2.0 (called as ineffective''). Also 123 age- and sex-matched individuals in sinus rhythm enrolled as control group (Group 3). After physical and echocardiographic examination, complete blood counts and INR were studied. There was no statistically significant difference in age, sex, co-morbidities and medications, also hemoglobin, white blood cell and platelet counts among the groups. The CHA(2)DS(2)-VASc scores were similar between Groups 1 and 2. The mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) were significantly higher in Group 2 than Groups 1 and 3 and similar between Groups 1 and 3. MPV was positively correlated with PDW and PCT and also inversely correlated with INR value and platelet count. On multivariate logistic regression analysis, MPV, PDW and PCT were independent predictors of ineffectiveness of INR. The results of this study showed that MPV, PDW and PCT are increased in patients with non-valvular AF without effective warfarin treatment. Warfarin usage adjusted by INR is associated with lower values of these platelet indices, even lower as the values of subjects in sinus rhythm. MPV, PDW and PCT are independent predictors of INR ineffectiveness and seem to be useful parameters for monitoring the effectiveness of warfarin treatment.
- MakaleAçık Erişim2013The prevalence of chronic bronchitis in adults living in the center of Gumushane
Tutar, Nuri; Yesilkaya, Selma; Memetoglu, Mehmet Erdem; Özel, Deniz; Bosnak, Emre
Introduction: Chronic bronchitis and emphysema are major components of chronic obstructive pulmonary diseases (COPD). The aim of this study was to determine the prevalence of chronic bronchitis 20 years and over living in the center of Gumushane and to analyze the risk factors. Materials and Methods: The study is targeted to reach 373 people who represent the center of Gumushane, 368 (98.6%) people have been reached. Participants were filled modified version of the questionnaire created by the Medical Research Council by face-to-face interview technique. Results: The prevalence of chronic bronchitis was 14.1%. The average age was in the chronic bronchitis group and nonchronic bronchitis group was respectively 43.2 +/- 12.9, 39.3 +/- 11.6, and the differance was statistically significant (p<0.05). Considering the relationship between cigarette smoking with chronic bronchitis, it was more frequent in smokers than nonsmokers (p<0.001, OR 4.74, 95% CI 2.47-9.17). Chronic bronchitis was observed in passive smokers than in non-smokers (p=0.004, OR 2.86, 95% CI 1.36-6.03). Occupational exposure to dust, fumes and history of childhood pulmonary diseases were increased chronic bronchitis prevalence (respectively, p<0.001, OR 9.53, 95% CI 4.56-19.94; p<0.001, OR 12.14, 95% CI 5.87-25.12). Male gender, low income level and to warm up with stove were found statistically significant by univariate logistic regression analysis but these risk factors were not statistically significant in the multivariate analysis. Educational level was not found statistically significant in both analysis (p>0.05). Conclusion: The prevalence of chronic bronchitis was 14.1% in 20 years and older adults living in the center of Gumushane. Old age (especially over the age of 50), active or passive smoking, occupational history of dust, fumes and history of childhood pulmonary diseases were found to be risk factors for chronic bronchitis.
- MakaleYalnız künye2012Endovenous ablation with a 940 nm laser for the treatment of great saphenous vein insufficiency: short- to mid-term results
Memetoglu, Mehmet Erdem; Kurtcan, Serpil; Erbasan, Ozan; Özel, Deniz
PURPOSE We aimed to present the short- to mid-term results of endovenous laser ablation (EVLA) procedures that were used to treat great saphenous vein (GSV) insufficiency. MATERIALS AND METHODS This prospective study was conducted between December 2009 and January 2011. A total of 112 incompetent GSVs were treated using EVLA with a 940 nm wavelength laser. Ninety patients were treated for varicose veins with saphenous reflux, including 36 females (40%) and 54 males (60%). These patients' ages ranged from 17 to 79 years (median, 48 years). After the EVLA, the patients were monitored using duplex ultrasonography and were assessed clinically at 1 week and 1, 3, 6, and 12 months after the surgery. The patients were scheduled for a three-day examination after the EVLA to assess the level of pain that each patient was experiencing in each limb. RESULTS At the end of a one-year follow-up period, the postprocedural duplex scans revealed a total occlusion of the treated GSVs in 88 (97%) patients and a sub-total occlusion in two (2%) patients. The average modified clinical, etiological, anatomical, and pathological score was significantly decreased at 12 months. The following complications were observed in the present study: hypoesthesia (11%), swelling and induration (5%), skin pigmentation (5%), deep vein thrombosis (1%), erythema (1%), and bleeding (1%). The mean visual analog pain score for the entire procedure was 3.14 +/- 1.06. CONCLUSION Our short- and mid-term results of the EVLA procedure were satisfactory, and the results of this study reaffirmed the safety and effectiveness of an EVLA using a 940 nm wavelength for the treatment of GSV insufficiency.
- MakaleAçık Erişim2010Combination technique of tumescent anesthesia during endovenous laser therapy of saphenous vein insufficiency
Memetoglu, Mehmet Erdem; Kurtcan, Serpil; Kalkan, Asim; Özel, Deniz
Objective: This study aimed at evaluating the efficiency of applying tumescent anesthesia before an ablation procedure and continuously during endovenous laser treatment (EVLT) (combined tumescent technique) of saphenous vein insufficiency to reduce the patients pain and discomfort. Methods: Twenty-five patients with 31 duplex-confirmed great saphenous vein insufficiency underwent endovenous laser (940 nm) varicose vein treatment between December 2009 and April 2010. The patients were randomized in two groups. In group A (15 patients) tumescent anesthesia was used before the ablation procedure and in group B (10 patients) tumescent anesthesia was used before and continuously during the procedure. Patients were scheduled for a three-day examination after EVLT to assess the level of pain experienced. Results: According to the statistic analysis we observed that the mean level of pain score for the patients given classical tumescent anesthesia showed a higher level (P=0.003) compared with the patients given tumescent anesthesia in the combined procedure. Conclusion: Combination technique of administering tumescent anesthesia before ablation and continuously during the EVLT procedure may be an alternative way to reduce the patient's peroperative pain and discomfort. (C) 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.