Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleYayıncıda açık erişim2014The evaluation of mean platelet volume levels in patients with primary and secondary Raynaud's Phenomenon
Memetoglu, Mehmet Erdem; Kutlu, Rasim; Memetoglu, Ozge Gulsum; Kehlibar, Tamer; Yilmaz, Mehmet; Günay, Rafet; Ketenci, Bulend; Güney, Mehmet Rasit; Demirtas, Mahmut Murat; Özel, Deniz
Background - Mean platelet volume (MPV) is an indicator of platelet activation. The pathophysiology of the primary and secondary Raynaud's Phenomenon (RP) have not been completely established. The aim of this study was to investigate the relationship between MPV and RP. Materials and Methods - Our study was a prospective randomized study carried out from January 2011 to March 2012. The study group consisted of 39 patients: 27 (70%) patients having primary, 12 (30%) patients having secondary RP. An age-, gender-, and body mass index-matched control group consisted of 40 healthy participants. We compared the MPV in patients with RP and control participants statistically. Results - MPV of RP group was 8.79 +/- 1.37 femtoliter (fL) while MPV of control group was 8.39 +/- 1.36 fL. Comparison of MPV of RP group and control group showed no difference (p = 0.274). The mean of MPV was significantly higher among patients with secondary RP (9.76 +/- 1.68 fl) when compared with patients with primary RP (8.37 +/- 0.96 fl) (p = 0.018). Conclusion - The results of our study suggest that MPV may be used as a marker in secondary RP.
- MakaleYalnız künye2014Relationship between platelet indices and international normalized ratio in patients with non-valvular atrial fibrillation
Arik, Osman Ziya; Özkan, Bugra; Kutlu, Rasim; Karal, Huseyin; Sahin, Durmus Yildiray; Kaypakli, Onur; Özel, Deniz; Çayil, Murat
Atrial fibrillation (AF) is the most common sustained arrhythmia and associated with adverse outcomes and increased risk for thromboembolic events. Warfarin is still the most extensively prescribed oral anticoagulant in AF to prevent ischemic complications. We aimed to determine the differences at platelet indices with warfarin usage layered by International Normalized Ratio (INR). A total of 250 patients with permanent non-valvular AF (mean age 70.2 +/- 9.1; 153 female) were divided into two groups. Group 1 included 125 patients whose INR is between 2.0 and 3.0 (called as effective'') and Group 2 included 125 patients whose INR is <2.0 (called as ineffective''). Also 123 age- and sex-matched individuals in sinus rhythm enrolled as control group (Group 3). After physical and echocardiographic examination, complete blood counts and INR were studied. There was no statistically significant difference in age, sex, co-morbidities and medications, also hemoglobin, white blood cell and platelet counts among the groups. The CHA(2)DS(2)-VASc scores were similar between Groups 1 and 2. The mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) were significantly higher in Group 2 than Groups 1 and 3 and similar between Groups 1 and 3. MPV was positively correlated with PDW and PCT and also inversely correlated with INR value and platelet count. On multivariate logistic regression analysis, MPV, PDW and PCT were independent predictors of ineffectiveness of INR. The results of this study showed that MPV, PDW and PCT are increased in patients with non-valvular AF without effective warfarin treatment. Warfarin usage adjusted by INR is associated with lower values of these platelet indices, even lower as the values of subjects in sinus rhythm. MPV, PDW and PCT are independent predictors of INR ineffectiveness and seem to be useful parameters for monitoring the effectiveness of warfarin treatment.
- BildiriYalnız künye2013Relationship Between Platelet Indices and International Normalized Ratio In Patients With Non-Valvular Atrial Fibrillation
Arik, Osman Ziya; Özkan, Bugra; Kutlu, Rasim; Karal, Huseyin; Memetoglu, Mehmet Erdem; Sahin, Durmus Yildiray; Tekin, Kamuran; Kaypakli, Onur; Uçak, Haci Ali; Çayli, Murat
- BildiriAçık Erişim2013In Coronary Artery Disease Comparison of Turkey and Europe According to Kyrgyzstan and Euroaspire III Results
Kutlu, Rasim; Memetoglu, Mehmet Erdem; Muratalievic, Tolkun Murataliev
- BildiriAçık Erişim2013The Pharmacoeconomic Efficacy of Ivabradine and Nebivolol Treatment of Stable Angina Pectoris in Patients with Left Ventricular Dysfunction
Kutlu, Rasim; Memetoglu, Mehmet Erdem
- MakaleAçık Erişim2013Evaluation of cardiovascular risk factors among university students in Turkey: a cross-sectional survey
Kutlu, Rasim; Memetoglu, Mehmet Erdem
Background - Recent data indicate increasing rates of mortality from cardiovascular (CV) disease in Turkey. This study aimed to evaluate CV disease risk factors among university students in Northern Turkey. Methods - In this cross sectional descriptive study, 302 students were randomly recruited (171 females (57%) and 131 males (43%), mean age of 20 +/- 2.1 years). Blood glucose, cholesterol profile (total, high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterols), triglyceride, glycosylated haemoglobin, resting blood pressure, and body mass index were measured using standard protocols. All participants were asked to complete a questionnaire including questions on lifestyle, genetic predisposition, smoking habit, and psychosocial factors. Results - The mean systolic and diastolic blood pressure of students were 127.1 +/- 13.5 mmHg and 78.3 +/- 12.4 mmHg. The mean values were 98.4 +/- 14.2 mg/dL for fasting blood glucose value, 5.4 +/- 0.4 for HbA(1c), 80.0 +/- 10.3 beats/min for heart rate, for total cholesterol 199.1 +/- 24.6 mg/dL, 43.8 +/- 9.9 mg/dL for HDL, 114.7 +/- 24.1 mg/dL for LDL, 199.1 +/- 24.6 mg/dL for trygliceride, 24.8 +/- 3.6 kg/m(2) for body mass index, 97.6 +/- 17.9 cm for waist circumference. No significant difference was observed between gender according to CV risk factors' values statistically. It was observed that 111 (36.8%) students were overweight, 32 (10.6%) were obes. About 135 (44.0%) of students had abnormally unacceptable WC value. Smoking habit was seen in 130 (43.0%) students [73 (24.2%) male and 57 (18.9%) female]. Conclusion - A substantial proportion of Turkish students were overweight or obese, and had smoking habit. Our results underscore the need to implement health promotion programmes and perform large-scale epidemiological studies within the general Turkish young adult population.
- BildiriAçık Erişim2013Evaluation of Cardiovascular Risk Factors Among University Students in Northern Turkey: A Cross-sectional Survey
Kutlu, Rasim; Memetoglu, Mehmet Erdem
- MakaleAçık Erişim2013Comparison of the safety and efficacy of ivabradine and nebivolol mono- and combination therapies in the treatment of stable angina pectoris patients with left ventricular dysfunction
Kutlu, Rasim; Memetoglu, Mehmet Erdem; Muratalievic, Tolkun Murataliev
We aimed to investigate the pharmacoeconomic efficacy of ivabradine and nebivolol in treatment of stable angina pectoris patients with left ventricular dysfunction prospectively. Pharmacoeconomic analysis was performed by using cost minimization analysis, and cost effectiveness analysis. After 6 months' treatment LVEF for the nebivolol group (17 patients, 50%) improved by (38 +/- 6.5) to (41 +/- 3.2), (p>0.05) and for the ivabradine group (17 patients, 50%) (37 +/- 5.4) to (41 +/- 2.3), (p>0.05), mean MET value in the nebivolol group increased from (3.7 +/- 1.2) to (5.5 +/- 1.6), (p>0.05), versus from (3.6 +/- 1.5) to (5.5 +/- 1.4), (p>0.05) in the ivabradine group, cost minimization analysis results showed a difference in the total cost of treatment was US$ 5288.7 in favor of nebivolol. The findings suggest that nebivolol is more cost-effective than ivabradine in the treatment of patients with left ventricular dysfunction.
- MakaleAçık Erişim2012Is Increased Mean Platelet Volume a Risk Factor in Patients with Acute Deep Vein Thrombosis?
Kalkan, Asim; Memetoglu, Mehmet Erdem; Bilir, Ozlem; Ersunan, Gokhan; Kutlu, Rasim; Tutar, Nuri
Objectives The purpose of this retrospective study was to compare the mean platelet volume between the patients with acute deep vein thrombosis (DVT) and control subjects. Methods Data were collected retrospectively from the patients' medical records. The study group consisted of 110 patients with newly diagnosed acute DVT in the lower extremities. An age, gender, and body mass index-matched control group consisted of 98 patients with normal duplex ultrasound findings. We compared the mean platelet volume in patients with acute DVT and control participants. Results There was no significant difference between the study and control groups in mean platelet volume (8.8 +/- 1.6 vs 8.7 +/- 1.3 fl, respectively; p>0.05). Age (p=0.899), body mass index (p=0.43), gender (p=0.466), and platelet count (p=0.886) were statistically similar in both groups. Conclusions There was no significant difference in mean platelet volume between patients with acute DVT and the control group. According to our result, we propose that mean platelet volume should not be considered as an index of acute DVT.