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- MakaleYalnız künye2025Scopus SJRQ2Chemical Composition and Bioactivities of Sideritis libanotica Labill subsp. Libanotica: LC–HRMS Phytochemical Profiling, Mineral Content, Antioxidant, Antibacterial, and Neuroprotective–Antidiabetic Enzyme Inhibitory Potentials
Öztürk Sarıkaya, Sevim Beyza; Zehiroğlu, Cuma
Sideritis libanotica Labill. subsp. libanotica (SLL) is an herbal tea used for colds, coughs, and digestive system disorders. SLL has higher antioxidant activity in methods (µg/mL) like 1,1-diphenyl-2-picrylhydrazyl (DPPH•) (40.912 ± 0.170), ABTS•+ (14.61 ± 0.331) scavenging activity, and Fe3+ (0.872 ± 0.052) and Cu2+ (0.840 ± 0.013) reduction capacity compared to other Sideritis species. It is rich in essential minerals, such as Ca, Mg, and P, with the highest content of mineral K (14 203.97 mg/kg). Zone values in the range of 9–11 mm were obtained from Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Pseudomonas putida, and Klebsiella pneumoniae strains, which is an indicator that the plant has antibacterial activity. Among 33 secondary metabolites, sinapinic acid, rutin, and hispidulin have high values, whereas the one with the highest value is verbascoside (274 483 mg/kg), a pharmacologically active compound. It showed an inhibitory effect (mg/mL) on some enzymes targeting neurodegenerative and metabolic disorders. (IC50; acetylcholinesterase [AChE]: 0.065, butyrylcholinesterase [BChE]: 0.086, α-glucosidase: 0.014).
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2024Exploring the Impacts of Angelica purpurascens Extracts on Anticholinergic, Antidiabetic, Antibacterial Potential, and Antioxidant Capacity
Topal, Meryem; Topal, Fevzi; Yilmaz, Fırat
In Kars-Sarıkamış-Soğanlı, Angelica purpurascens (A. purpurascens) emerges as a promising natural antioxidant source. Extracts from its leaves, branches, and flowers underwent thorough bioanalytical assessments. The leaf extract exhibited the highest concentrations of herbal flavonoids (45.22 µg QE/mg extract) and total phenolics (28.96 µg GAE/mg extract). Branch extracts demonstrated significant enzymatic activity against AChE and BChE with IC50 values of 37.26 mg/mL and 9.08 mg/mL respectively. The flower extract displayed notable antibacterial properties. This study sheds light on the therapeutic potential of A. purpurascens ethanol extracts, suggesting benefits for Alzheimer’s, cell damage-induced diseases, and diabetes mellitus. It pioneers new enzymatic and antioxidant insights and contributes to understanding this abundant Türkiye species. A. purpurascens holds promise for pharmaceutical exploration, offering potential solutions for challenging health conditions.
AtıfScopus1OpenAlex3TR Dizin2İncele - MakaleYalnız künye2023Scopus SJRQ2Endemic Mountain Tea (Sideritis dichotoma Huter): Antioxidant and Antibacterial Activities, Mineral Content by ICP-MS and Phytochemical Content by LCHR-MS
Öztürk Sarıkaya, Sevim Beyza; Zehiroğlu, Cuma
Endemic Sideritis dichotoma Huter, herbal tea, is used for colds, coughs and digestive ailments. Since at least 25 % of the active ingredients of pharmacological drugs are obtained from plants, it is important to investigate many plants, both traditionally used and whose potential hasnt yet been discovered, before they disappear. When the results compared to other Sideritis species, it has better antioxidant activity in DPPH⋅ scavenging activity, Fe3+ and Cu2+ reducing capacity methods and is also rich in minerals, necessary for human body, K, Mg, Ca, P, S. Zone values (10–19,5 mm) obtained on S. aureus, P. aeruginosa, E. coli, S.enteritidis, E. faecalis, P. putida and K. pnemoniae strains are an indication that the plant has antibacterial activity. 27 secondary metabolites were identified by LC-HRMS. Verbascoside, pharmacologically active compound known to have antitumor effect, cytotoxic selectivity and anticancer activity, is the most abundant phenolic in ethanol extract (49297.13 mg/kg).
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