Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Kaya, Elif Çelenk(5)
- Durmuş, Mahmut(2)
- Kantekin, Halit(2)
- Bulut Atalay, Esra(1)
- Dakoǧlu, Asuman(1)
- Elmali, Ayhan(1)
- Ersoy, Sibel(1)
- Güzel, Emre(1)
- Kahriman, Nuran(1)
- KantekiN, Halit(1)
- Karabulut, Mevlut(1)
- Karabulutlu, Nur(1)
- Karadeniz, Hülya(1)
- Kaya, A. A.(1)
- Kaya, Afşin Ahmet(1)
- Kaya, Ahmet Afşin(1)
- Koca, Atif(1)
- Koçyiğit, Ümit Muhammet(1)
- Sökmen, Atalay(1)
- Topal, Fevzi(1)
- Topal, Meryem(1)
- Yanmaz, Ekrem(1)
- Yilmaz, Fırat(1)
- Yuksek, Mustafa(1)
- Çelenk Kaya, Elif(1)
- Öksüz, Sümeyra(1)
- Şişik, Hanife(1)
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ3Investigation of the enzyme-inhibitory, antibacterial, and anticancer properties of metal phthalocyanines
Topal, Meryem; Topal, Fevzi; Yilmaz, Fırat; Bulut Atalay, Esra; Koçyiğit, Ümit Muhammet; Güzel, Emre
In this study, the enzyme inhibitory, antibacterial, and anticancer activities of a phthalonitrile derivative and its metal phthalocyanines (Pcs; indium, zinc, copper, cobalt, and manganese; 1–6) were investigated. The cobalt and manganese Pcs were synthesized for the first time in this study. The inhibitory activities of the symmetric Pcs, which were expected to interact with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) via their 4-(isopropylbenzyl)oxy substituents through host–guest interactions, were investigated. More selective inhibition of AChE than BChE was observed for these compounds. For AChE, CoPc was identified as the most potent inhibitor (IC50 = 14.81 nM), whereas for BChE, InPc was identified as the most potent inhibitor (IC50 = 56.35 nM). The Ki values indicated that most compounds exhibited competitive inhibition; copper phthalocyanine (CuPc) showed particularly strong inhibition against AChE (Ki = 3.08 nM ± 1.12), whereas the lowest Ki value against BChE was observed for MnPc (Ki = 25.98 ± 1.97 nM). Most compounds exhibited competitive inhibition; however, CuPc showed competitive inhibition toward AChE but a noncompetitive inhibition pattern toward BChE. Dual inhibition of AChE and BChE by these compounds may be promising for addressing cholinergic deficits associated with Alzheimer’s disease. In addition, the acceptability of compounds 1–6 with respect to pharmacological drug-likeness criteria was assessed based on predicted absorption, distribution, metabolism, excretion (ADME) outcomes. In antibacterial tests, varying levels of inhibition were observed against selected bacterial strains. In anticancer assays, all compounds exhibited high cytotoxicity against the MCF-7 breast cancer cell line. Higher antiproliferative activity was observed for CuPc than for the other compounds. Morphological changes were induced in cancer cells by CuPc and MnPc. Overall, these compounds may have potential as enzyme inhibitors and as antibacterial and anticancer agents.
AtıfScopus2WoS2OpenAlex2
İncele - MakaleYalnız künye2019Scopus SJRQ1Enhancing of the nonlinear absorption and optical limiting performances of the phthalocyanine thin films by adding of the single walled carbon nanotubes in poly(methyl methacrylate) host
Yuksek, Mustafa; Kaya, Elif Çelenk; Karabulutlu, Nur; Kaya, Ahmet Afşin; Karabulut, Mevlut; Elmali, Ayhan
Unlike the earlier nonlinear optical studies of single walled carbon nanotubes (SWCNTs) which were generally carried out as solvent, in this study, we established to deposit the unsoluble SWCNTs as homogeneous thin films by blending them with phthalocyanines in PMMA host. The structural and morphological features of the thin films were studied by SEM and TEM imaging techniques while the linear, nonlinear-absorptions and carrier dynamic properties of the thin films were investigated with the UV–Vis spectrophotometer, open aperture Z-scan experiments and pump-probe technique, respectively. In addition, the optical limiting performances of the samples were calculated from nonlinear absorption spectra. It was observed that the linear- and nonlinear-absorptions and optical limiting performance of the thin films increased with the mixing of the SWCNT sample with the Pcs complexes. We have clearly explained the mechanisms contributing to the nonlinear optical absorption and optical limiting performances.
AtıfScopus12WoS11OpenAlex10İncele - MakaleAçık Erişim2018Scopus SJRQ4Synthesis of fluorine-containing phthalocyanines and investigation of the photophysical and photochemical properties of the metal-free and zinc phthalocyanines
Çelenk Kaya, Elif; Ersoy, Sibel; Durmuş, Mahmut; Kantekin, Halit
4-(3-(Trifluoromethyl)benzylthio)phthalonitrile (1) was synthesized. Metal-free phthalocyanine 2, zinc(II) phthalocyanine 3 and cobalt(II) phthalocyanine 4 were synthesized starting with dinitrile compound 1. Photodynamic therapy properties of 2 and 3 were studied.
AtıfScopus8WoS7OpenAlex5İncele - MakaleYalnız künye2015Synthesis, characterization and thermal behaviour of novel phthalocyanines bearing chalcone groups on peripheral positions
Kaya, A. A.
A new nickel, zinc, cobalt, copper and metal-free phthalocyanine was synthesized by nucleophilic aromatic substitution reaction of (E)-3-(3-hydroxyphenyl)-1-phenylprop-2-en-1-one with 4-nitrophthalonitrile and cyclotetramerisation of (E)-4-(3-(3-oxo-3-phenylprop-1-enyl)phenoxy) phthalonitrile. The new compounds were characterized by a combination of IR, H-1 NMR, C-13 NMR, UV-Vis, elemental analysis and MS spectral data. The thermal stabilities of the phthalocyanine compounds were determined by thermogravimetric analysis.
AtıfWoS2İncele - MakaleAçık Erişim2014Scopus SJRQ3Synthesis and spectral and thermal characterization of new metal-free and metallophthalocyanines: Investigation of their photophysical, photochemical, and thin film properties
Kaya, Elif Çelenk; Durmuş, Mahmut; Yanmaz, Ekrem; KantekiN, Halit
Novel tetrasubstituted metal-free (2), zinc (II) (3), cobalt (II) (4), and copper (II) (5) phthalocyanines bearing 2-phenylethanolate groups on the peripheral positions were synthesized by the cyclotetramerization reaction of the phthalonitrile derivative 1. The new compounds were characterized by a combination of IR, 1H NMR, 13 C NMR, UV-Vis, elemental analysis, and MS spectra data. The thermal stabilities of the phthalocyanine compounds were determined by thermogravimetric analysis. For metal-free (2) and zinc (3) phthalocyanines, photochemical (photodegradation and singlet oxygen quantum yields) and photophysical (fluorescence quantum yields and fluorescence lifetimes) properties were analyzed in dimethylsulfoxide (DMSO). The cobalt (4) and copper (5) phthalocyanines were not evaluated for this purpose because of their paramagnetic behavior. The metal-free (2) and zinc (3) phthalocyanines' fluorescence quenching behaviors were also investigated. The new phthalocyanine compounds' fluorescence emissions were effectively quenched by 1,4-benzoquinone in DMSO. The thin films of the cobalt phthalocyanine compound (4) were grown by electron beam evaporation technique. Crystalline CoPc (4) thin films were investigated by X-ray diffraction spectroscopy. Surface morphology of the CoPc (4) thin films was characterized by SEM.
AtıfScopus13WoS11OpenAlex15İncele - MakaleYalnız künye2012Scopus SJRQ3Synthesis and characterisation of new metallophthalocyanines containing four 12-membered diazadithia-macrocyclic moieties
Kaya, Elif Çelenk; Kantekin, Halit; Kaya, Afşin Ahmet; Dakoǧlu, Asuman; Öksüz, Sümeyra; Şişik, Hanife
Tetrasubstituted zinc, cobalt, nickel, copper and lead phthalocyanines bearing four 12-membered diazadithia macrocyclic moieties on peripheral positions have been synthesised by cyclotetramerisation reaction of 1,10-ditosyl-1,2,3,5,6,8,9,10-octahydrobenzo[h][1,4,7,10] dithiadiazacyclododecine-12,13-dicarbonitrile and corresponding anhydrous metal salts under microwave irradiation. The thermal stabilities of the phthalocyanine compounds have determined by thermogravimetric analysis.
AtıfScopus1WoS2OpenAlex1İncele - MakaleAçık Erişim2012Scopus SJRQ3Synthesis and antimicrobial activity of new phthalocyanine complexes and electrochemical and spectroelectrochemical behaviour of cobaltphthalocyanine
Kaya, Elif Çelenk; Karadeniz, Hülya; Koca, Atif; Kahriman, Nuran; Sökmen, Atalay
A novel phthalocyanine bearing oxygen donor atoms on the peripheral positions has been synthesised by cyclotetramerisation of (E)-4-(4- cinnamoylphenoxy) phthalonitrile and its nickel, zinc, cobalt, copper and lead derivatives prepared. The thermal stabilities of the phthalocyanine compounds have been determined and their possible biological activities (antibacterial, anticandidal and antifungal) studied. The effects of substituent on the electrochemical and in situ spectroelectrochemical behaviour of cobaltphthalocyanine have been investigated and an in situ electrocolorimetric method was applied to investigate the colour of the electrogenerated anionic and cationic forms of the complex.
AtıfScopus5WoS4OpenAlex4İncele - MakaleAçık Erişim2012Scopus SJRQ4Synthesis and characterization of new metallophthalocyanines bearing macrocyclic N 3O 2 groups on peripheral positions
Kaya, Elif Çelenk
The synthesis and characterization of new zinc(II) 3 , nickel(II) 4 and cobalt(II) 5 phthalocyanines complexes carrying macrocyclic N 3 O 2 groups on peripheral positions are described. The compounds were characterized by elemental analysis, IR, 1 H and 13 C NMR, UV-Vis and MS spectral data.
AtıfScopus1WoS1OpenAlex1İncele