Sürdürülebilir Kalkınma Amaçları

• 2

Yazarlar

• Sandalli, Cemal(2)
• Alitntop, Yasemin Ay(1)
• Balci, Pervin Özlem(1)
• Bonnin, Remy A.(1)
• Ceylan, Aysenur(1)
• Cicek, Aysegul Copur(1)
• Dal, Tuba(1)
• Duzgun, Azer Ozad(1)
• Düzgün, Azer Özad(1)
• Firat, Mehmet(1)
• Iraz, Meryem(1)
• Kayman, Tuba(1)
• Nordmann, Patrice(1)
• Saral, Aysegul(1)
• Saral, Ayşegül(1)
• Tosun, Ismail(1)
• Yazici, Yelda(1)
• ÇIzmecI, Zeynep(1)
• ÇIÇek, Ayşegül Çopur(1)
• Çalişkan, Ahmet(1)

• MakaleYalnız künye2014Scopus SJRQ1/r/gumushane/10597
  Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey

  Iraz, Meryem; Duzgun, Azer Ozad; Cicek, Aysegul Copur; Bonnin, Remy A.; Ceylan, Aysenur; Saral, Aysegul; Nordmann, Patrice; Sandalli, Cemal

  Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), extensively-drug resistant (n = 5), or pan-drug resistant (n = I). PCR and DNA sequence analysis revealed that 1 strain possessed the bla(GES-5) and another carried a novel bla(VIM) variant, named VIM-38. This new gene exhibited 1 amino acid substitution (Ala265Val) in comparison to its closest variant, VIM-5. Both VIM encoding genes were clones and demonstrated similar susceptibility profile when expressed in identical background. The presence of VIM-38 increases the diversity of carbapenemases in Turkey. (C) 2014 Elsevier Inc. All rights reserved.

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  AtıfScopus27·WoS24·OpenAlex24

  İncele
• MakaleAçık Erişim2013Scopus SJRQ2/r/gumushane/13127
  Detection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkey

  ÇIÇek, Ayşegül Çopur; Düzgün, Azer Özad; Saral, Ayşegül; Kayman, Tuba; ÇIzmecI, Zeynep; Balci, Pervin Özlem; Dal, Tuba; Firat, Mehmet; Tosun, Ismail; Alitntop, Yasemin Ay

  Objective: To investigate the antibiotic resistance genes inserted into class 1 and class 2 integrons in Acinetobacter baumannii (A. baumannii) isolates obtained from nine different cities in Turkey. Methods: A collection of 281 A. baumannii clinical isolates were collected from nine diferent state hospitals in Turkey and were confirmed as A. baumannii by conventional biochemical, API testing and bla-OXA-51 specific PCR. The isolates were examined by PCR for existence of class 1 and 2 integron gene cassettes. Results: They were characterized by antimicrobial susceptibility testing and the highest resistance rates were determined for piperacillin (90.03%), ciprofloxacin (87.54%), cefepime and trimethoprim/sulfamethoxazole (81.13%). The lowest resistance rates was for cefotaxime (3.55%). class I integrons were detected in 6.4% (18/281) of A. baumannii strains and no class 2 integron was detected. The gene cassettes of class 1 integrons AacC1-AAC(3) I-aadA1, AacC1-aadA1, AAC(3)-I, AAC(3)-I -AAC(3)-I -aadA1, TEM-1, AAC(3)-I-aadA1 - AAC(3)-I -AAC(3)-I, AAC(3)-I -AAC(3)-I -AAC(3)-I -aadA1, AAC(3)-I - aadA1, AAC(3)-I-AAC(3)-I, AAC(3)-I-aadA1-AAC(3)-I-aadA1, AAC(3)-I-AAC(3)-I-aadA1-AAC(3)-I-aadA1 were detected in eighteen strains. The aac genes family were most frequently found integrated into the class 1 integrons and it was followed by aadA genes and TEM-1 genes. Conclusions: This is an extensive study on the distribution of class 1 integron among A. baumannii in Turkey. In addition to these, two new alleles were observed. Their percentage rates of similarity to other cassettes are 95% aadA1 (TKA18) and 89% aadA1 (ANKA3).

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  AtıfScopus25·OpenAlex24

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