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- MakaleAçık Erişim2025The Protective Effect of Boric Acid Against High Fructose-Induced Liver and Kidney Damage in Rats
Yüksel, Duygu; Başeğmez, Mehmet; Kan, Fahriye
This study aimed to determine the protective role of boric acid (BA) in high fructose (HF)-induced liver and kidney toxicity in a young rat model. High-fructose consumption causes serious damage to liver and kidney tissue in healthy individuals and contributes to the emergence of various metabolic diseases. Thirty-two healthy female Wistar albino rats (250–300 g weight and 3–4 months) were randomly distributed into four equal groups (n = 8): control, high fructose % 20 (HF), boric acid 20 mg/kg (BA), and HF + BA. High fructose was freshly prepared and administered to the rats as 20 g of d-fructose dissolved in 100 mL of tap water daily for a duration of 30 days. Boric acid (20 mg/kg) was administered through gastric gavage throughout the 30-day study period. At the end of study, blood, liver, and kidney were collected from rats. The results indicated that high fructose induced increased glucose, total cholesterol, triglyceride, and urea levels in rat serum. Boric acid administration significantly decreased glucose, total cholesterol, triglyceride, and urea levels in HF + BA groups. The results indicated that high fructose-induced oxidative stress by increasing the level of MDA and by decreasing GSH levels, and CAT activity in the liver and kidney of rats. However, oral BA administration significantly decreased MDA levels and increased GSH levels, and CAT activity (p < 0.05). Furthermore, BA significantly reduced high fructose-induced histopathological and Immunohistochemistry alteration in the liver and kidney tissues. In conclusion, BA may prevent the oxidative imbalance and histopathological and immunohistochemical damage caused by high fructose in liver and kidney tissues in rats.
- MakaleAçık Erişim2025The Effect of Boric Acid on Oxidative Stress, Inflammation, and Apoptosis in Embryonic and Fetal Tissues Damage Caused by Consumption of High-Fructose Corn Syrup in Pregnant Rats
Başeğmez, Mehmet; Yüksel, Duygu
This study aimed to determine the protective role of boric acid in a pregnant rat model of high fructose corn syrup consumption. Consumption of high fructose corn syrup has been associated with adverse health outcomes in humans and animals. Twenty-eight healthy female Wistar albino rats (250–300 g weight and 16–24 weeks old) were randomly distributed into four equal groups (n = 7): Control, Boric acid (BA), High Fructose Corn Syrup (HFCS), HFCS + BA. Boric acid (20 mg/kg) was administered to pregnant rats via oral gavage every day during pregnancy. The prepared 30% HFCS (F30) solution (24% fructose, 28% dextrose) was added to the drinking water throughout pregnancy. At the end of pregnancy (day 19), blood, placenta, uterus, and fetuses were collected from rats. The results indicated that HFCS increases oxidative stress by increasing the level of MDA and decreasing GSH, SOD, and CAT activity in the blood of maternal. However, BA administration significantly decreased MDA levels and increased GSH levels, SOD, and CAT activity (p < 0.05). In addition, HFCS consumption significantly increased plasma TNF-α, IL-6, and leptin levels compared to control, BA, and HFCS + BA groups (p < 0.05). However, BA administration significantly decreased plasma TNF-α, IL-6, and leptin levels (p < 0.05). Furthermore, BA (20 mg/kg) significantly decreased HFCS-induced histopathological and immunohistochemical alterations in the placenta, uterus, and fetal tissue. In conclusion, BA may prevent HFCS toxicity in maternal and fetal tissues, as it regulates oxidative imbalance in pregnant rat and alleviates histopathological and immunohistochemical changes. The findings indicate a need for further studies to assess the potential of boron in preventing or mitigating the effects of HFCS during pregnancy.
- MakaleYalnız künye2018Determination of certain properties of scotch pine (Pinus sylvestris L.) wood which is impregnated with boron compounds and Quechua
Sen, Selim; Said Fidan, M.; Alkan, Elif; Sadiye Yaşar, S.
As the industrialisation and technological developments increase; the search for functional material which is environment-friendly, non-toxic, flame resistant, with a broad applicability and with high-temperature endurance also increases. Even though the wood material corresponds most of these features, its possession of an organic structure causes it to be affected negatively by damages occurring under proper conditions in the outdoor environment. Due to this reason, this study is conducted to prevent damages (biotic, abiotic pests, fire, etc.) caused by the environment to the wooden material, and to determine some physical and mechanical properties of wooden material impregnated with quechua, borax and boric acid, which are used to extend the usage life. Those features are needed in an outdoor environment. The Scotch pine (Pinus sylvestris L.) test specimens are prepared with borax, boric acid, borax+boric acid, from borax compounds, which have a great potential in Turkey, and with quechua, one of the natural impregnation substances. Then these samples are impregnated with three different (1%, 3%, 5%) solution concentrations according to ASTM 1413-76 standards and some physical-mechanical property changes are investigated. After impregnation, samples are tested and compared with control samples. According to the test results; the lowest oven dried density change is obtained in borax as 0.46 g . cm -3 in terms of boron compounds and the retention amount is determined to be highest with 3.83 kg.m -3 in the samples impregnated with boric acid. The bending strength and elastic modulus are found to be highest with 83.53 MPa and 10281 MPa in the samples impregnated with boric acid. When examined at the concentration level, it is determined to be highest with 81.89 MPa in samples with 3% concentration. There are statistical discrepancies with 55.77 MPa in the comprehensive strength parallel to grain in boric acid in terms of boron compounds.