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Yayınlar
- Yüksek Lisans TeziAçık Erişim2019Gümüşhane'de bulunan Astragalus microcephalus Willd. ve Astragalus plumosus Wild. bitkilerinin oksidatif hasara karşı koruyucu ve antidiyabetik etkilerinin incelenmesi
Ayşe Arslan
Gümüşhane ilimiz bulunduğu coğrafi konumdan dolayı farklı iklimlerin etkisi altında kalmıştır. Bu durum ilimizin bitki örtüsü bakımından zengin olmasına ve çeşitli Astragalus türlerine ev sahipliği yapmasına sebep olmuştur. Astragalus cinsi Fabaceae familyasına dahil olup Astragalus türlerinin antioksidan, anti-inflamatuar, antimikrobiyal, antidiyabetik, yaşlanmayı geciktirici ve antiviral etkinlikleri belirlenmiştir. Söz konusu bu etkilerinin bitkilerin içeriğinde bulunan fenolik bileşikler ve saponinlerden kaynaklandığı bildirilmektedir. Bu türlerin yaprak ekstraktlarının, kimyasal ve biyoaktif özellikleri toplam polifenolik içerik, toplam flavonoid içerik, demir indirgeyici güç, hemoliz inhibisyonu, alfa-glukozidaz inhibisyonu ile serumda oksidatif hasar analizleri spektrofotometrik yöntemler kullanılarak belirlendi. Çalışılan bitki ekstraktlarının en yüksek toplam polifenol içeriği gram örnek başına Astragalus plumosus'un etanollü esktraktında 13.9 mg, Astragalus microcephalus'un etanollü ekstraktında ise 14.8 mg gallik asit eşdeğeri olarak bulundu. Bitkilerin en yüksek toplam flavonoid içerikleri gram örnek başına A. plumosus'un PBS'li ektraktında 4.19 mg, A. microcephalus'un sulu ekstraktında 6.18 mg kuersetin eşdeğeri olarak bulundu. Bitkilerin en yüksek demir indirgeyici güç aktivitesine gram örnek başına A. plumosus'un PBS'li ekstraktında 13 mg, A. microcephalus'un sulu ekstraktında 13.8 mg troloks eşdeğeri olarak bulundu. Bitki ekstraktlarının en yüksek DPPH radikalini giderme aktivitesi A. plumosus'un sulu ekstraktında %14.6 ve A. microcephalus'un PBS'li ekstraktında %19 olarak bulundu. A. plumosus ve A. microcephalus 25 mg/mL etanol ekstraktlarının en yüksek alfa glukozidaz inhibisyonu A. plumosus ekstraktında %39.9 olarak bulundu. A. plumosus ve A. microcephalus bitkilerinin üç farklı konsantrasyonda hazırlanan PBS'li ekstraktlarındaki en yüksek hemoliz ihhibisyonu değeri A. plumosus ekstraktında %97.7 olarak bulundu. A. plumosus ve A. microcephalus bitkilerinin PBS'li ekstraktlarında TAS değerleri sırasıyla 1.41 ve 1.44 mmol troloks eşdeğeri şeklinde, TOS değerleri 25.8 ve 24.7 µmol H2O2 eşdeğeri olarak OSİ değerleri ise sırasıyla 1.83 ve 1.71 µmol H2O2 Eq/L şeklinde verildi. Yapılan bu çalışma sonucunda bitki ekstraktlarımızın alfa glukozidaz enzim inhibisyonu ve hemoliz inhibisyonunu sağladığı, serumda oluşturulan oksidatif hasarın bitki ektraktları tarafından giderildiği sonucuna varıldı. Bu sonuçlar doğrultusunda bitkilerimizin biyoteknoloji alanında alternatif, tamamlayıcı bir ürün olarak oksidatif hasarın sebep olduğu hastalıkların tedavisinde gıda ve ilaç olarak kullanılabileceği öngörülmektedir.
- Derleme MakaleAçık Erişim2019Scopus SJRQ2The importance of antioxidants and place in today’s scientific and technological studies
Zehiroglu, Cuma; Ozturk Sarikaya, Sevim Beyza
Antioxidants have become scientifically interesting compounds due to their many benefits such as anti-aging and anti-inflammatory. Today, it is still used in many areas. In food technology, antioxidants are added to many foodstuffs in order to enrich the foods and eliminate the problems. Therefore, studies to determine the antioxidant activities of natural foods and their components are also continuing rapidly. Antioxidants have also been replaced in the encapsulation studies used for the preservation and stabilization of food components. Of course, preservation of foods is as important as their production. The latest packaging techniques for food preservation are edible films and coatings. The protective function of edible films and coatings can be improved by the addition of antioxidants. Unlike these, studies on plants and animals have been investigated in vivo in terms of how the antioxidant activity changes as a result of metabolic activities. The role of antioxidant enzymes in these studies is quite large. Many results have been found for the elimination of diseases by either in vivo or in vitro studies regarding antioxidants. Thus, the importance of antioxidants increased with the use in pharmacology, cosmetics and medicine. In this study, we tried to bring a current perspective to antioxidants played an active role in many fields by combining the technological applications and scientific studies of antioxidants. In order to further customize the issue, we have done this especially for the food and health field and we have tried to emphasize the importance of antioxidants in this way.
AtıfScopus252WoS190OpenAlex273İncele - MakaleYalnız künye2017Scopus SJRQ1An on-line HPLC system for detection of antioxidant compounds in some plant extracts by comparing three different methods
Arslan Burnaz, Nesibe; Küçük, Murat; Akar, Zeynep
Echinacea (Echinacea purpurea), green tea (Camellia sinensis) and yaylacayi (Thymus praecox OPIZ subsp. grossheimii (Ronniger) Jalas) are herbs used in traditional medicine because of their beneficial health effects. A high performance liquid chromatography (HPLC) post-column method was developed by coupling HPLC with on-line antioxidant assays using diode array (DAD) and ultraviolet (UV) detectors. Thus antioxidant compounds and fifteen phenolic standards were detected in echinacea, green tea and yaylacayi methanol extracts simultaneously. Later on, the developed on-line HPLC coupled system was used to compare three different antioxidant methods, ABTS [2,2′-Azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid)], DPPH (2,2-diphenyl-1-picrylhydrazyl and FRAP (Ferric reducing antioxidant power). Eight compounds with antioxidant activity were identified as gallic acid, protocatechuic aldehyde, p-OH benzoic acid, chlorogenic acid, caffeic acid, vanillin, ferulic acid, and rosmarinic acid. For validation purposes, LOD (limit of detection) (0.36–14.68 μg/mL) and LOQ (limit of quantification) (1.35–48.92 μg/mL) values were calculated for six standards. The results showed that while the post-column ABTS and FRAP assays were repeatable, sensitive and supportive of each other, the post-column DPPH assay did not provide reliable results. Also due to the base-line noise and drifts in post-column DPPH assay, identification and quantitation of analytes could not be done accurately.
AtıfScopus46WoS42OpenAlex52İncele - Derleme MakaleAçık Erişim2016Scopus SJRQ1Higher PUFA and n-3 PUFA, conjugated linoleic acid, α-tocopherol and iron, but lower iodine and selenium concentrations in organic milk: a systematic literature review and meta- and redundancy analyses
Srednicka-Tober, Dominika; Baranski, Marcin; Seal, Chris J.; Sanderson, Roy; Benbrook, Charles; Steinshamn, Havard; Gromadzka-Ostrowska, Joanna; Rembialkowska, Ewa; Skwarlo-Sonta, Krystyna; Eyre, Mick
Demand for organic milk is partially driven by consumer perceptions that it is more nutritious. However, there is still considerable uncertainty over whether the use of organic production standards affects milk quality. Here we report results of meta-analyses based on 170 published studies comparing the nutrient content of organic and conventional bovine milk. There were no significant differences in total SFA and MUFA concentrations between organic and conventional milk. However, concentrations of total PUFA and n-3 PUFA were significantly higher in organic milk, by an estimated 7 (95% CI -1, 15)% and 56 (95% CI 38, 74) %, respectively. Concentrations of alpha-linolenic acid (ALA), very long-chain n-3 fatty acids (EPA + DPA + DHA) and conjugated linoleic acid were also significantly higher in organic milk, by an 69 (95% CI 53, 84) %, 57 (95% CI 27, 87)% and 41 ( 95% CI 14, 68) %, respectively. As there were no significant differences in total n-6 PUFA and linoleic acid (LA) concentrations, the n-6:n-3 and LA: ALA ratios were lower in organic milk, by an estimated 71 (95% CI -122, -20)% and 93 (95% CI -116, -70) %. It is concluded that organic bovine milk has a more desirable fatty acid composition than conventional milk. Meta-analyses also showed that organic milk has significantly higher alpha-tocopherol and Fe, but lower I and Se concentrations. Redundancy analysis of data from a large cross-European milk quality survey indicates that the higher grazing/conserved forage intakes in organic systems were the main reason for milk composition differences.
AtıfScopus197WoS154OpenAlex212İncele - MakaleYayıncıda açık erişim2014Scopus SJRQ1Characterization of rosehip (Rosa canina L.) seed and seed oil
Ilyasoǧlu, Huri
In this study, the nutritional composition and phytochemical composition of the rosehip seed, and the fatty acid and sterol compositions of the seed oil were investigated. The rosehip seed contained valuable phytochemicals such as phenolic compounds (2554 μg/g), carotenoids (2.92 μg/g), and ascorbic acid (1798 μg/g). Furthermore, the rosehip-seed oil was rich in polyunsaturated fatty acids, linoleic acid (54.05%), linolenic acid (19.37%), and phytosterols, mainly β-sitosterol (82.1%). The rosehip seed and seed oil were found to have antioxidant activity measured by trolox equivalent antioxidant capacity assay. It can be concluded that the rosehip seed and seed oil may be utilized as a source of phytonutrients.
AtıfScopus106WoS96OpenAlex111İncele - MakaleYalnız künye2011Scopus SJRQ3Effects of kale (Brassica oleracea L. var. acephala DC) leaves extracts on the susceptibility of very low and low density lipoproteins to oxidation
Kural, Birgül Vanizor; Küçük, Nurçin; Yücesan, Fulya Balaban; Örem, Asim
Of Brassicaceous plants, kale (Brassica oleraceae L. var. acephala DC) contains polyphenols, flavonoids, isoflavones and glucosinolates and so has antioxidant and anticarcinogenic properties. Antioxidants inhibit negative effects of free radicals and may, therefore, protect tissues against oxidative damage. Oxidation of lipoproteins is a key event in the development of atherosclerosis. In the current study, the levels of total phenolic and flavonoid contents and total antioxidant capacity of methanolic and aqueous extracts of kale leaves were determined. In addition, the susceptibility of isolated lipoproteins - very low density lipoprotein (VLDL) and low density lipoprotein (LDL) to the Cu 2+-induced oxidation with various concentrations of metanolic and aqueous extracts was evaluated as t-lag values. Although aqueous extract had higher total antioxidant capacity, methanolic extract had higher total phenolic and flavonoid content (P<0.05). On the other hand, both extracts inhibited lipid peroxidation in both isolated VLDL and LDL. Inhibitory effect of extracts or increasing t-lag values, mainly in methanolic extract was found to be related to increasing the concentration of extracts. It was concluded that because of high antioxidant capacity and phenolic content, kale showed a protective effect on the oxidation of lipoproteins. Therefore, it may be speculated that kale consumption may play an important protective role in the cardiovascular and other related diseases resulting from imbalance of oxidant and antioxidant status.
AtıfScopus16WoS13İncele