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- MakaleYalnız künye2022Determination of the Factors Affecting the COVID-19 Knowledge Levels and the Status of Being Diagnosed with COVID-19 in Healthcare Employees Struggling with Pandemic
Sahin, Ceyda Uzun; Kulakaç, Nurşen
The present study was conducted to determine of the factors affecting the COVID-19 knowledge levels and the status of being diagnosed with COVID-19 in healthcare employees struggling with the pandemic. This study, which was planned in cross-sectional and descriptive-correlational design. The healthcare employees working in hospitals in 6 city centers in the Black Sea Region, which has the highest number of COVID-19 cases in Turkey, were included in the study (n=385). It was determined in the present study that 33.85±9.11 (min.20, max.60), 57.9% of the participants were female, 43.4% were nurses, and 47% were infected with coronavirus. It was found that the factors that affected the coronavirus knowledge scores of health employees significantly were being diagnosed with COVID-19, presence of chronic diseases, receiving psychological support, female gender, and fighting COVID-19 in the front line. The risk factors for being infected with coronavirus disease were found to be the lack of personal protective equipment, unit worked at, and N95 mask replacement time (p<0.05). As a result of this study, ıt is recommended to provide evidence-based trainings to prevent transmission of future outbreaks and to support coping strengths since infection in healthcare employees is high.
- MakaleYalnız künye2021Effects of Aged Garlic Extracts On Caspase-3 Activity In Myeloid Cancer Cell Lines
Cengiz, Sevil; Uçar, Fahri; Uçar, Meltem; Orhan, Deger; Yigit Gerigelmez, Asuman
Garlic (Allium sativum) is a spice used for centuries for both condiment and medicinal purposes. Studies have shown that it has antibacterial, antiviral, anti-inflammatory, antifungal, antimutagenic, antioxidant, antiallergic, anti-aging, antitumoral and immunostimulatory activities. Activation of caspase3 initiates the caspase activation chain, leading to apoptosis. In this study aimed to determine the apoptotic effect of DMSO-containing aged garlic extracts (AGE) on Myoid Cancer Cell lines (HL-60). Flow cytometry method and spectrophotometric caspase-3 activity analyzes were used using human lymphocyte cells as a control group. The highest apoptotic effect on HL-60 cell lines was observed in aged garlic extracts at a concentration of 12.5 mg/mL (10.9%). It was determined that caspase-3 activity in HL-60 cell lines increased by 1.28 to 3.02 times compared to lymphocyte cells. It was concluded that aged garlic extracts triggered apoptosis by increasing the activity of caspase-3 in HL-60 cell lines. It is thought that the aging of garlic has an anticancer effect and additional studies on this subject may bring new perspectives to cancer treatment.