Gümüşhane ÜniversitesiGümüşhane ÜniversitesiAçık Erişim Arşivi · RDL Open

Cytotoxic effect of Turkish propolis on liver, colon, breast, cervix and prostate cancer cell lines

MakaleAçık ErişimScopus SJRQ4
  • SDG 3 · Sağlık ve Kaliteli Yaşam

Özet

Purpose: To investigate the total polyphenolic and flavonoid contents, antioxidant power and cytotoxic activity of ethanol extracts of Turkish propolis (EEP). Methods: The total polyphenolic and flavonoid contents of EEP were determined by spectrometric methods. Antioxidant power and cytotoxic activity of EEP were evaluated using ferric reducing antioxidant power (FRAP) and MTT assays, respectively. Results: The total polyphenolic and flavonoid contents, and FRAP value of EEP were 124.6 ± 1.5 mg gallic acid/g sample dry weight, 42.0 ± 0.8 mg quercetin/g sample dry weight and 311.0 ± 2.5 mg trolox/g sample dry weight, respectively. EEP exhibited powerful cytotoxic effects against the five human cancer cell lines. The highest cytotoxic activity of Turkish EEP was demonstrated on PC-3 cell line (IC50 = 20.7±3.4 μg/mL). Conclusion: The results demonstrate that EEP is a good source of antioxidant and a natural antitumor agent capable of reducing cancer cell proliferation.

Anahtar Kelimeler

Antioxidant activityCancer cell linesCytotoxic effectPolyphenolsPropolis
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/gumushane/15441Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.4314/tjpr.v14i5.5Yayıncı resmi DOI adresi
Atıflar
Scopus
64
WoS
60
OpenAlex
71
Her kaynağın kendi saydığı toplam atıf; aktarım ve zenginleştirme sırasında alındı.
Tam Kayıt
AlanDeğerDil
dc.contributor.authorTuran, Ibrahim
dc.contributor.authorDemir, Selim
dc.contributor.authorMisir, Sema
dc.contributor.authorKilinc, Kagan
dc.contributor.authorMentese, Ahmet
dc.contributor.authorAliyazicioglu, Yuksel
dc.contributor.authorDeger, Orhan
dc.date.accessioned2026-10-22T10:24:01.075352639Z
dc.date.available2026-10-22T10:24:01.075352639Z
dc.date.issued2015
dc.description.abstractPurpose: To investigate the total polyphenolic and flavonoid contents, antioxidant power and cytotoxic activity of ethanol extracts of Turkish propolis (EEP). Methods: The total polyphenolic and flavonoid contents of EEP were determined by spectrometric methods. Antioxidant power and cytotoxic activity of EEP were evaluated using ferric reducing antioxidant power (FRAP) and MTT assays, respectively. Results: The total polyphenolic and flavonoid contents, and FRAP value of EEP were 124.6 ± 1.5 mg gallic acid/g sample dry weight, 42.0 ± 0.8 mg quercetin/g sample dry weight and 311.0 ± 2.5 mg trolox/g sample dry weight, respectively. EEP exhibited powerful cytotoxic effects against the five human cancer cell lines. The highest cytotoxic activity of Turkish EEP was demonstrated on PC-3 cell line (IC50 = 20.7±3.4 μg/mL). Conclusion: The results demonstrate that EEP is a good source of antioxidant and a natural antitumor agent capable of reducing cancer cell proliferation.
dc.description.sponsorshipFoundation of Scientific Research of Karadeniz Technical University, Trabzon, Turkey [2007.114.001.3, 2008.114.001.5]
dc.identifier.doi10.4314/tjpr.v14i5.5
dc.identifier.endpage782
dc.identifier.issn1596-5996
dc.identifier.issue5
dc.identifier.scopus2-s2.0-84930036530
dc.identifier.startpage777
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/gumushane/15441
dc.identifier.volume14
dc.identifier.wosWOS:000355931400005
dc.language.isoen
dc.publisherUniversity of Benin
dc.relation.ispartofTropical Journal of Pharmaceutical Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidant activity
dc.subjectCancer cell lines
dc.subjectCytotoxic effect
dc.subjectPolyphenols
dc.subjectPropolis
dc.subject.classificationPharmacology & Pharmacy
dc.subject.otheralcohol
dc.subject.othercisplatin
dc.subject.otherflavonoid
dc.subject.othergallic acid
dc.subject.othernatural product
dc.subject.otherpolyphenol
dc.subject.otherquercetin
dc.subject.othertrolox C
dc.subject.otherTurkish propolis extract
dc.subject.otherunclassified drug
dc.subject.otherantioxidant activity
dc.subject.otherantioxidant assay
dc.subject.otherArticle
dc.subject.othercancer cell line
dc.subject.othercell viability
dc.subject.othercontrolled study
dc.subject.otherdrug cytotoxicity
dc.subject.otherdrug screening
dc.subject.otherhuman
dc.subject.otherhuman cell
dc.subject.otherIC50
dc.subject.otherMTT assay
dc.subject.otherphytochemistry
dc.titleCytotoxic effect of Turkish propolis on liver, colon, breast, cervix and prostate cancer cell lines
dc.typeArticle
dspace.entity.typePublication
rdl.citation.openalex71
rdl.citation.scopus64
rdl.citation.wos60
rdl.oa.statusgold
rdl.oa.urlhttps://www.ajol.info/index.php/tjpr/article/download/122908/112450
rdl.scopus.quartileQ4
rdl.sdgSDG03
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)