Gümüşhane ÜniversitesiGümüşhane ÜniversitesiAçık Erişim Arşivi · RDL Open

In vitro inhibition of α-carbonic anhydrase isozymes by some phenolic compounds

MakaleAçık Erişim
  • SDG 3 · Sağlık ve Kaliteli Yaşam

Özet

Carbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as antiglaucoma agents, diuretics, antiepileptics, in the management of mountain sickness, gastric and duodenal ulcers, neurological disorders or osteoporosis. We report here the inhibitory capacities of some phenolic compounds against three human CA isozymes (hCA I, hCA II, and hCA VI) and the gill carbonic anhydrase of the teleost fish Dicentrarchus labrax (European seabass) (dCA). The isozymes showed quite diverse inhibition profiles with these compounds. These data may lead to design novel CAIs with a diverse inhibition mechanism compared to sulfonamide/sulfamate inhibitors.

Anahtar Kelimeler

AntiglaucomaCarbonic anhydrasedCAhCA VIhCA-IhCA-IIInhibitionPyrogallolTannic acid
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/gumushane/13199Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.1016/j.bmcl.2011.05.071Yayıncı resmi DOI adresi
Tam Kayıt
AlanDeğerDil
dc.contributor.authorÖztürk Sarikaya, Sevim Beyza
dc.contributor.authorTopal, Fevzi
dc.contributor.authorŞentürk, Murat
dc.contributor.authorGülin, Ihami
dc.contributor.authorSupuran, Claudiu T.
dc.date.accessioned2026-10-22T10:21:03.265884872Z
dc.date.available2026-10-22T10:21:03.265884872Z
dc.date.issued2011
dc.description.abstractCarbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as antiglaucoma agents, diuretics, antiepileptics, in the management of mountain sickness, gastric and duodenal ulcers, neurological disorders or osteoporosis. We report here the inhibitory capacities of some phenolic compounds against three human CA isozymes (hCA I, hCA II, and hCA VI) and the gill carbonic anhydrase of the teleost fish Dicentrarchus labrax (European seabass) (dCA). The isozymes showed quite diverse inhibition profiles with these compounds. These data may lead to design novel CAIs with a diverse inhibition mechanism compared to sulfonamide/sulfamate inhibitors.
dc.description.sponsorshipAgri Ibrahim Cecen University Scientific Research Council, (Agri BAP- 2010/K-10)
dc.description.sponsorshipDPT, (2010K120440)
dc.description.sponsorshipTurkish Republic Prime Ministry State Planning Organization
dc.identifier.doi10.1016/j.bmcl.2011.05.071
dc.identifier.eissn1464-3405
dc.identifier.endpage4262
dc.identifier.issn1464-3405
dc.identifier.issue14
dc.identifier.pmid21669522
dc.identifier.scopus2-s2.0-79959902277
dc.identifier.startpage4259
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/gumushane/13199
dc.identifier.volume21
dc.identifier.wosWOS:000292186400030
dc.language.isoen
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofBioorganic and Medicinal Chemistry Letters
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntiglaucoma
dc.subjectCarbonic anhydrase
dc.subjectdCA
dc.subjecthCA VI
dc.subjecthCA-I
dc.subjecthCA-II
dc.subjectInhibition
dc.subjectPyrogallol
dc.subjectTannic acid
dc.subject.classificationChemistry, Medicinal
dc.subject.classificationChemistry, Organic
dc.subject.classificationPharmacology & Pharmacy
dc.subject.classificationChemistry
dc.subject.otherAnimals
dc.subject.otherBass
dc.subject.otherCarbonic Anhydrase I
dc.subject.otherCarbonic Anhydrase II
dc.subject.otherCarbonic Anhydrase Inhibitors
dc.subject.otherCarbonic Anhydrases
dc.subject.otherFish Proteins
dc.subject.otherHumans
dc.subject.otherIsoenzymes
dc.subject.otherPhenols
dc.subject.otherSulfonamides
dc.subject.otherSulfonic Acids
dc.subject.otherDicentrarchus labrax
dc.subject.otherTeleostei
dc.subject.other3 hydroxybenzoic acid
dc.subject.other4 hydroxybenzoic acid
dc.subject.otheracetazolamide
dc.subject.otheralpha resorcylic acid
dc.subject.othercarbonate dehydratase
dc.subject.othercarbonate dehydratase I
dc.subject.othercarbonate dehydratase II
dc.subject.othercarbonate dehydratase inhibitor
dc.subject.othercarbonate dehydratase vi
dc.subject.othercatechol
dc.subject.othergallic acid
dc.subject.otherhydroquinone
dc.subject.otherphenol
dc.subject.otherphenol derivative
dc.subject.otherprotocatechuic acid
dc.subject.otherpyrogallol
dc.subject.otherresorcinol
dc.subject.othersalicylic acid
dc.subject.othertannin
dc.subject.otherunclassified drug
dc.subject.otherarticle
dc.subject.othercontrolled study
dc.subject.otherdrug protein binding
dc.subject.otherenzyme inhibition
dc.subject.otherEuropean sea bass
dc.subject.otherin vitro study
dc.titleIn vitro inhibition of α-carbonic anhydrase isozymes by some phenolic compounds
dc.typeArticle
dspace.entity.typePublication
rdl.citation.openalex175
rdl.citation.scopus179
rdl.citation.wos171
rdl.departmentGumushane University, Food Engineering Department, 29000 Gumushane, Turkey
rdl.oa.statusgreen
rdl.oa.statuspreprint
rdl.oa.urlhttps://hdl.handle.net/20.500.12501/1243
rdl.sdgSDG03
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)