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- Derleme MakaleAçık Erişim2021COVID-19 vaccine and immune response
Hintistan, Sevilay; Demirağ, Hatice
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; βCoV), the causative agent of coronavirus disease 2019 (COVID-19), causes severe lower respiratory tract infections and acute respiratory failure syndrome (ARDS). Deaths due to the ongoing COVID-19 pandemic for more than a year are still seen worldwide. Therefore, vaccine trials have gained importance. The discovery of the genome and protein structure of SARS-CoV-2 in a short time allowed the development of nucleic acid-based vaccines (mRNA and DNA vaccines), vector vaccines, inactivated virus vaccines, protein-based vaccines, virus-like particle vaccines, and live attenuated virus vaccines. Many companies, universities, and institutes around the world continue to develop effective vaccines against SARS-CoV-2. In this review, the structural features, classification, genome, and intracellular entry of SARS-CoV-2 coronaviruses, stimulation of the immune system and immunity, COVID-19 vaccine types, and the latest status of clinical trials of these vaccines have been reviewed.
- Derleme MakaleAçık Erişim2020Vaccination Studies Against COVID-19 Agent: Current Status
Hintistan, Sevilay; Kazak, Aysun
The emergence of the new pathogenic viral strains is a constant threat to global health. The latest new coronavirus strain coronavirus-2019 (COVID-19) is the best-known example of this. COVID-19, caused by the severe acute respiratory syndrome-CoV-2 virus has quickly spread around the globe. The applications of drug and vaccine practices, and the identification of potential candidates are of high importance against this pandemic. On healthy adults, a proper evaluation of potential vaccines in parallel with vaccination studies on animal models and an enlargement of production capacity will benefit minimum risk and accelerated COVID-19 vaccine studies for human subjects. The purpose of this review is to contribute to the analysis of vaccine development strategies, vaccine development stages, phase studies and the difficulties, production stages and current status of potential vaccine studies developed to prevent COVID-19.