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Yazarlar

• Aliyazicioglu, Rezzan(1)
• Barlak, Yasam(1)
• Deger, Orhan(1)
• Erem, Cihangir(1)
• Kural, Birgul Vanizor(1)
• Turan, Ibrahim(1)
• Yücesan, Fulya Balaban(1)

• MakaleAçık Erişim2013/r/gumushane/16115
  Sequence Variant in the LPIN1 gene in Patients with Metabolic Syndrome

  Kural, Birgul Vanizor; Deger, Orhan; Erem, Cihangir; Yücesan, Fulya Balaban; Barlak, Yasam; Turan, Ibrahim; Aliyazicioglu, Rezzan

  Objective: Metabolic syndrome (MetS) is a complex disease characterized by insulin resistance, abdominal obesity, hyperglycemia, hypertension, hypertriglyceridemia and low HDL-cholesterol level. The aim of the study was to evaluate the sequence variations in the LPIN1 gene in MetS. This gene codes lipin-1 protein which functions as Mg-dependent phosphatidic phosphatase enzyme and transcriptional coactivator. Material and Methods: The study groups included 73 MetS (19 M/54 F) and 56 non-MetS (16 M/40 F). Sequence variation in exons 2, 4, 5 and 14 of the LPIN1 gene were investigated by DNA sequencing method. Results: c.696 G>C variant (p.S232S) in exon 5 was observed in only one women with MetS. But this variation is not important because of coding same amino acid. Conclusion: Any important sequence variant was not detected in exons 2, 4, 5 and 14 in the LPIN1 gene in MetS.

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