Sürdürülebilir Kalkınma Amaçları

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Yazarlar

• Alver, Ahmet(1)
• Atayan, Yahya(1)
• Demir, Selim(1)
• Fidan, Evren(1)
• Fidan, Sami(1)
• Hacisalihoglu, Payam(1)
• Kavgaci, Halil(1)
• Mentese, Ahmet(1)
• Sumer, Aysegul(1)
• Turan, Ibrahim(1)
• Yaman, Serap Ozer(1)

• MakaleYalnız künye2017/r/gumushane/16247
  The correlation between tissue Helicobacter pylori severity and the increase in serum neutrophil/lymphocyte ratio in patients with active chronic gastritis

  Atayan, Yahya; Hacisalihoglu, Payam

  Introduction: Helicobacter pylori are a microaerophile gram-negative bacteria and the most frequent factor of chronic gastritis. Recently, there has been an inclination to various non-invasive tests to determine the severity of H. pylori infection in the gastric tissue. The serum neutrophils/lymphocytes rate (NLR) is a simple, safe, non-invasive and active inflammation reagent. The purpose of this study is examining the correlation between the increase in the positivity/severity of H. pylori infection and the increase in the NLR. Material and method: 149 patients were included into the study by considering the Sydney criteria in accordance with H. pylori severity degrees in 3 groups; Mild (n=49), Moderate-Severe (n=67) and Severe (n=33). A Control Group was also formed (n=22) with negative H. pylori by three experienced pathologists. Result: It has been determined that the severity has increased among the groups with H. pylori positive as regard to the increase in serum NLR (r: 0.295, p: 0.017), there has been a significant correlation has been determined between the Control Group and the Moderate-Severe patients (p:0.014), the Severe patients (p:0.002). Conclusion: It is suggested that the serum NLR, which can be used in order to predict the severity of the H. pylori Infection in patients with chronic gastritis, can be a practical, inexpensive and non-invasive test.

  AtıfWoS3

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• MakaleAçık Erişim2017Scopus SJRQ3/r/gumushane/12986
  Detection of autoantibodies against carbonic anhydrase I and II in the plasma of patients with gastric cancer

  Mentese, Ahmet; Fidan, Evren; Alver, Ahmet; Demir, Selim; Yaman, Serap Ozer; Sumer, Aysegul; Fidan, Sami; Kavgaci, Halil; Turan, Ibrahim

  Cancer is the second leading cause of death and gastric cancer is the fourth most common cancer type worldwide. Investigation of autoantibodies in cancer patients has been a popular research area in recent years. The aim of the current study was to investigate carbonic anhydrase I and II (CA I and II) autoantibodies in the plasma of subjects with gastric cancer based on the information and considerations of autoimmune relation of gastric cancer. Anti-CA I and II antibody levels were investigated by ELISA in plasma samples of fifty two patients with gastric cancer and thirty five healthy peers. Anti-CA I and II antibody titers of the gastric cancer group were significantly higher compared with the control group (p = 0.004, p = 0.0001, respectively). Plasma anti-CA I levels of the metastatic group were lower than the non-metastatic group and this difference was found statistically significant (p < 0.05), but there was no statistical difference between plasma anti-CA II levels of the groups. CA I and II autoantibody titers in patients with gastric cancer were found higher compared to healthy subjects and the results suggest that these autoantibodies may be involved in the pathogenesis of gastric cancer.

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  AtıfScopus8·WoS7·OpenAlex7

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