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- Gulcin, Ilhami(5)
- Topal, Fevzi(5)
- Topal, Meryem(4)
- Aygül, İmdat(3)
- Gülçin, Ilhami(3)
- Supuran, Claudiu T.(3)
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- Balci, Neslihan(2)
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- Fidan, Muhammed Said(2)
- Keskin, Ali(2)
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- Yagi, Sakina(2)
- Yapici, Ismail(2)
- Yildiztugay, Evren(2)
- Zengin, Gokhan(2)
- Çelik, Murat(2)
- Öz, Mehmet(2)
- AKMEŞE, Osman(1)
- AYGÜL, İmdat(1)
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- Akşit, Berfin(1)
- Alwasel, Saleh H.(1)
- Aslan, Kubra(1)
- Atmaca, Ufuk(1)
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Yayınlar
- MakaleAçık Erişim2015Scopus SJRQ1N-Acylsulfonamides strongly inhibit human carbonic anhydrase isoenzymes i and II
Yildirim, Alper; Atmaca, Ufuk; Keskin, Ali; Topal, Meryem; Çelik, Murat; Gülçin, Ilhami; Supuran, Claudiu T.
Sulfonamides represent a significant class of biologically active compounds that inhibit carbonic anhydrase (CA, EC.: 4.2.1.1) isoenzymes involved in different pathological and physiological events. Sulfonamide CA inhibitors are used therapeutically as diuretic, antiglaucoma, antiobesity and anticancer agents. A series of new sulfonamides were synthesized using imides and tosyl chloride as starting materials. These N-acylsulfonamides efficiently inhibited the cytosolic human carbonic anhydrase isoenzymes I, and II (hCA I, and II), with nanomolar range inhibition constants ranging between 36.4 ± 6.0-254.6 ± 18.0 and 58.3 ± 0.6-273.3 ± 2.5 nM, respectively.
AtıfScopus158WoS155
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