Sürdürülebilir Kalkınma Amaçları
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- MakaleYalnız künye2017Lasting hepatotoxic effects of prenatal mobile phone exposure
Yilmaz, A.; Tumkaya, L.; Akyildiz, K.; Kalkan, Y.; Bodur, A.F.; Sargin, F.; Efe, H.; Uydu, H.A.; Yazici, Z.A.
Objective: In this study, the livers of rats born to mothers exposed to electromagnetic field (EMF) were examined 60 days postpartum for biochemical and histopathological changes. Methods: Pregnant rats were exposed to radiation (900 MHz EMF, 24 h/day for 20 days) using a digital signal generator by placing the device centrally under the cage, which formed the study (EMF) group, while untreated matching rats served as controls. Livers and blood were obtained from litters (seven males and seven females) of both groups 60 days after birth, which were used for biochemical and histopathological analyses. Results: There was a significant increase in the levels of malondialdehyde (MDA) (p <0.05) that was accompanied by a significant fall in glutathione (GSH) (p <0.01) in the liver. The serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were significantly increased (p <0.05). Histopathologically, the liver sections of the EMF group showed intense degeneration in hepatocytes with cytoplasmic eosinophilic structures, pyknotic nuclei and fibrosis. Conclusion: We demonstrate that the intrauterin harmful effects of EMF on the livers of rats persist into adulthood.
- MakaleAçık Erişim2013The effect of prenatal exposure to 900-MHz electromagnetic field on the 21-old-day rat testicle
Hanci, Hatice; Odaci, Ersan; Kaya, Haydar; Aliyazicioǧlu, Yüksel; Turan, Ibrahim; Demir, Selim; Çolakoǧlu, Serdar
The aim of this study was to investigate the effect of exposure to a 900-MHz electromagnetic field (EMF) in the prenatal term on the 21-old-day rat testicle. Pregnant rats were divided into control (CG) and EMF (EMFG) groups. EMFG was exposed to 900-MHz EMF during days 13-21 of pregnancy. Newborn CG rats were obtained from the CG and newborn EMFG (NEMFG) rats from the EMFG. Testicles were extracted at postnatal day 21. Lipid peroxidation and DNA oxidation levels, apoptotic index and histopathological damage scores were compared. NEMFG rats exhibited irregularities in seminiferous tubule basal membrane and epithelium, immature germ cells in the lumen, and a decreased diameter in seminiferous tubules and thickness of epithelium. Apoptotic index, lipid peroxidation and DNA oxidation were higher in NEMFG rats than in NCG. 21-day-old rat testicles exposed to 900-MHz EMF in the prenatal term may be adversely affected, and this effect persists after birth.