Sürdürülebilir Kalkınma Amaçları

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Yazarlar

• Bonnin, Remy A.(1)
• Ceylan, Aysenur(1)
• Cicek, Aysegul Copur(1)
• Duzgun, Azer Ozad(1)
• Iraz, Meryem(1)
• Nordmann, Patrice(1)
• Sandalli, Cemal(1)
• Saral, Aysegul(1)

• MakaleYalnız künye2014/r/gumushane/10597
  Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey

  Iraz, Meryem; Duzgun, Azer Ozad; Cicek, Aysegul Copur; Bonnin, Remy A.; Ceylan, Aysenur; Saral, Aysegul; Nordmann, Patrice; Sandalli, Cemal

  Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), extensively-drug resistant (n = 5), or pan-drug resistant (n = I). PCR and DNA sequence analysis revealed that 1 strain possessed the bla(GES-5) and another carried a novel bla(VIM) variant, named VIM-38. This new gene exhibited 1 amino acid substitution (Ala265Val) in comparison to its closest variant, VIM-5. Both VIM encoding genes were clones and demonstrated similar susceptibility profile when expressed in identical background. The presence of VIM-38 increases the diversity of carbapenemases in Turkey. (C) 2014 Elsevier Inc. All rights reserved.

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