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- MakaleAçık Erişim2025Biological activities and phenolic content of endemic Helichrysum artvinense P.H. Davis et Kupicha (Asteraceae)
Acet, Tuba; Özcan, Kadriye; Kalmuk, Nursen Aksu
Species from the Asteraceae family have been extensively utilized in traditional medicine and as food sources for centuries. They also exhibit important biological activities attributed to their diverse array of phytochemical compounds. This research aimed to determine total phenolic and flavonoid contents of ethanol (EtOH) and methanol (MeOH) extracts of endemic Helichrysum artvinense and to reveal its antioxidant, antimicrobial enzyme inhibitory (α-glucosidase, α-amylase, and tyrosinase) and DNA protective activities. In addition, phenolic compound analyses were conducted using high-performance liquid chromatography (HPLC), establishing a correlation with the aforementioned biological activities. Based on the obtained data, the ethanol (EtOH) extract of the plant demonstrated greater prominence in terms of the screened biological activities. This extract was found to contain significant phenolic components, including epicatechin, chlorogenic acid, and luteolin. Consequently, it appears that the plant has the potential to serve as a natural alternative in both food and pharmacological applications. However, further studies to elucidate the mechanisms underlying the observed biological activities would be beneficial for the product development phase.
- MakaleAçık Erişim2020RP-HPLC-UV Analysis of the Phenolic Compounds, Antimicrobial Activity Against Multi-Drug Resistant Bacteria and Antioxidant Activity of Fruit and Seed of Diospyros lotus L.
Akar, Zeynep; Karakurt, Aylin; Okumus, Funda; Cinemre, Sedanur; Duzgun, Azer Ozad; Akar, Bulent; Can, Zehra
The object of the present study was to investigate the antioxidant, antimicrobial activity and phenolic compounds of fruit and seeds of Diospyros lotus L. The fruits consumed by humans as nutrients were harvested from the plants that grow naturally in the province of Trabzon-Akçaabat, Eastern Black Sea Region of Turkey. The antioxidant activities of fruit and seeds of Diospyros lotus were determined by using four methods (% DPPH radical scavenging activity, FRAP antioxidant power determination, CUPRAC reducing antioxidant activity and total phenolic content (TPC) in five different proportion of methanol-water extracts. All extracts of fruit and seeds of D. lotus analyzed through whole antioxidant analysis methods showed significant antioxidant activity. In addition, antimicrobial activity of fruit and seeds extracted with DMSO was determined against seven standard bacteria and three multi-drug resistance clinical strains. Although fruit extracts did not have the antimicrobial activity against bacteria, seeds showed antimicrobial effect to both standard strains (Gram-negative and Gram-positive) and antibiotic resistance clinical isolates (Klebsiella pneumoniae carrying blaKPC, Acinetobacter baumannii, harboring blaOXA-23 gene and resistance to colistin, and multi-drug resistant Pseudomonas aeruginosa). MICs’ value of plant seed extracts for standard strains was 0.75-25 mg/mL and antibiotic resistant clinical bacteria were 12.5 and 25 mg/mL. Additionally, phenolic compounds in methanol extracts of fruit and seeds were also determined in by HPLC using 19 standards. Gallic acid and chrysin phenolic compounds were the major phenolic compounds in fruit and seeds, respectively.
- MakaleAçık Erişim2020Some Quality Criteria of Valerian (Valeriana dioscoridis Sm.) Growing in Different Environments
Uçar, Esra; Ataş, Mehmet; Çilesiz, Yeter; Çinbilgel, İlker; Eruygur, Nuraniye; Oral, İrem Zeynep; Karaköy, Tolga
Valerian (Valeriana dioscoridis Sm.) is a perennial herb of the Caprifoliaceae family. The genus Valeriana L. is represented by 14 species (15 taxa) in Turkey. This plant contains flavone glycosides, iridoids and lignans. Among these components, the medically important active ingredient is valerianic acid. Essential oils from valerian roots and rhizomes are used for the treatment of various diseases, including insomnia, mental illness, anxiety, menstrual cramps and physical stress conditions. In this study, evaluations were made of the root and rhizome of valerian plants grown in a natural environment and in greenhouse condition. The macro and micro nutrient contents of the powdered plant samples, and the antioxidant and antimicrobial activity values of the extracts were reported. Except for some macro and micro elements, it was determined that antioxidant and antimicrobial activities of plants cultivated and grown in nature were not different. The major components of both the natural and cultivated forms were determined to be 9-Borabicyclo [3.3.1] nonane, 9-[3-(dimethylamino) propyl]- (17.55% and 22.65%, respectively). The heavy metales such as Fe (415.21±47.8 mg/kg), Cu (50.9±0.2 mg/kg) and Mn (274.6±9.5 mg/kg), were obtained above limit values in grown plants of natural environment conditions.
- DergiInternational Journal of Secondary Metabolite