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- MakaleYalnız künye2022Evaluation of Serum Procalcitonin, Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio in Pregnancies with Threatened Abortion
Aydin, Sakine Merve; Taskömür, Aysun Tekeli
Objective: The etiology of Threatened Abortion is not clearly known. One of the hypotheses thought to play a role in the pathophysiology of threatened abortion is that bleeding occurring in threatened abortion causes the development of a chronic inflammatory reaction in the decidua. Because of this hypothesis, we aimed to evaluate the relationship between a threatened abortion and inflammatory markers procalcitonin, neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR). Methods: This is a prospective, controlled study. Serum procalcitonin, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio of 55 pregnant women diagnosed with threatened abortion were compared with the results of 55 healthy pregnant women. ROC analysis of procalcitonin, NLR and PLR was performed for threatened abortions. Results: Procalcitonin and NLR levels were significantly higher in the threatened abortions group than in the control group (p < 0.05). The area under the curve (AUC) in ROC analysis was within the 95% confidence interval for procalcitonin and NLR, both of which were statistically significant (p < 0.05). Procalcitonin and NLR resulted as appropriate parameters as diagnostic decision-makers in predicting threatened abortions. Conclusion: There is an association between procalcitonin and NLR and threatened abortion. This result may support that inflammatory reaction plays a role in the etiology of threatened abortion.
AtıfWoS1
İncele - MakaleYalnız künye2016Scopus SJRQ2Do early procalcitonine levels aid in predicting mortality in burn patients?
Piroglu, Isilay Demir; Tulgar, Serkan; Piroglu, Mustafa Devrim; Thomas, David Terence; Karakilic, Evvah; Gergerli, Ruken; Ates, Nagihan Gozde; Demir, Ahmet
Aim: Burn patients in intensive care units (ICU) are at high risk of mortality. Our aim in this stuy is to evaluate the use of first 48 hour procalcitonin level (PCT), C-reactive protein (CRP) and APACHE II score for the prediction of mortality in burn patients admitted to ICU. Material and method: Files of patients with burns admitted to a tertiary centre's burn unit were retrospectively analysed and those with procalcitonin and C-reactive protein level measurements and APACHE II scores within first 48 hours of admittance were included in this study. Patients with comorbidities that would effect PCT and CRP levels such as chronic renal or liver failure were excluded from the study. Patients PCT, CRP and APACHE II scores were compared with the outcome of patients. Results: Seventy patients were included in this study. While CRP levels were lower in patients that were deceased, PCT levels were significantly higher in these patients. In patients with APACHE II score > 20 and PCT > 2 ng/ml, mortality was statistically very significantly higher compared with other patients. Logistical regression analysis showed that high PCT levels and APACHE II scores were important at predicting mortality in these patients. Conclusion: High PCT levels within 48 hours of burns is a predictor of mortality in these patients. Additional studies are required to correctly determine the cut-off value. A modified scoring system including APACHE II and PCT may be useful for better predicting mortality, although larger multi-centered studies are required.
AtıfWoS3İncele