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- MakaleAçık Erişim2026The effect of hawthorn vinegar, black mulberry syrup, and green tea on oral mucositis and oral health-related quality of life in individuals with diabetes: a single-blind, randomized controlled trial
Demiraǧ, Hatice; Akeren, Zahide
Objective – This study was designed as a single-blind randomized controlled trial to investigate the effects of hawthorn vinegar, black mulberry syrup, and green tea on oral mucositis and quality of life related to oral health in individuals with diabetes. Methods – Total of 120 participants were divided into four groups (hawthorn vinegar, black mulberry syrup, green tea, control; n = 30 each) and the study was completed. All participants completed the “Patient Information Form, ” “Oral Assessment Guide (OAG/ADR), ” and “Oral Health-Related Quality of Life Scale (OHQoL-UK)” before the study, on the 7th day, and after the study. In the experimental groups (hawthorn vinegar group, black mulberry syrup group, green tea group). In addition to routine oral mucositis treatment, patients with DM gargled for 1 min with diluted hawthorn vinegar [1 tablespoon (10 cc) mixed with 40 cc of water], pure black mulberry syrup, or green tea solution three times a day for 14 days, 15–20 min before meals. Results – Patients in the hawthorn vinegar group showed a decrease in oral mucositis and an increase in oral health-related quality of life at the interim measurement (day 7) and final test (day 14) measurements (p < 0.05). A negative correlation was found between the severity of oral mucositis and quality of life (p < 0.05). Conclusion – Although there was no difference between hawthorn vinegar and black mulberry syrup, they were found to be more effective than green tea in reducing oral mucositis and improving oral health-related quality of life, and all three complementary treatments were found to be effective. Clinical Trial Registration – identifier [NCT06481254]. https://register.clinicaltrials.gov/prs/beta/studies/S000E5O000000043/recordSummary.
- Kitap BölümüYalnız künye2019Mucositis treatment
Doğan, Melike Demir
Mucositis is defined as inflammatory and/or ulcerative lesions of the oral and/or gastrointestinal system. It is one of the side effects of radiotherapy and chemotherapy used in cancer treatment. The incidence rate of mucositis is 15-40% in standard-dose chemotherapy, 76-100% in high-dose chemotherapy and bone marrow transplant, and 100% in radiation therapy applied for head-neck. While oral mucositis can cause pain as well as sensitivity in mouth and throat, it can also severely affect oral functions such as swallowing, taste, and speaking. Severe mucositis leads to increase the pain in the oral mucosa. Many pharmacological and non-pharmacological options are available to treat mucositis. The literature reveals studies looking at pharmacological approaches including oral care involving 0.9% NaCl and NaHCO3, benzydamine hydrochloride, saline mouthwashes, calcium phosphate mouthwashes, magic mouthwash, and mouthwashes containing G-CSF and GM-CSF. Likewise, studies looking at non-pharmacological approaches focus on cryotherapy, low energy laser treatment, hypnosis, herbal approaches, honey, and black mulberry molasses.
- MakaleYalnız künye2017Effectiveness of Black Mulberry Molasses in Prevention of Radiotherapy-Induced Oral Mucositis: A Randomized Controlled Study in Head and Neck Cancer Patients
Doǧan, Melike Demir; Can, Gulbeyaz; Meral, Rasim
Objectives: Radiation-induced oral mucositis is one of the problems experienced by 70%-80% of patients receiving radiation therapy (RT). This randomized controlled trial assessed the effectiveness of black mulberry molasses in the prevention of oral mucositis in head and neck cancer patients receiving RT. Interventions and Outcome measures: Eighty head and neck cancer patients scheduled to undergo RT to the oropharyngeal mucosa were randomly assigned to receive RT (42) or RT plus mulberry molasses (38). The research data were collected with a Patient Description Form, Common Terminology Criteria for Adverse Events, version 4.0, an Oral Assessment Guide, and the University of Washington Quality of Life Assessment Questionnaire. Results: The incidence and severity of oral mucositis were lower in the black mulberry molasses group. However, black mulberry molasses usage was an only independent and significant factor in prevention of mucositis [HR 0.63 (%95 GI 0.40-0.98)]. There were no differences between the quality of life scores of experimental and control groups. Conclusions: This randomized controlled study showed that black mulberry molasses usage is an effective intervention in the prevention of the radiation-induced mucositis of head and neck cancer patients. However, to confirm these results, further studies are needed.