Sürdürülebilir Kalkınma Amaçları
Yazarlar
Yayınlar
- MakaleYalnız künye2017Scopus SJRQ3Selection application of material to be used in hip prosthesis production with analytic hierarchy process: Anwendungsselektion des zu verwendenden Materials in der Hüftprothesenproduktion mit dem analytischen Hierarchieverfahren
Çelik, İ.; Eroğlu, H.
Metallic biomaterials used in making hip prosthesis are required to meet expectations in terms of fatigue strength, corrosion resistance, wear resistance, cost and biocompatibility. It is also desirable that the modulus of elasticity they possess is close to the level of the possible bone. Metallic biomaterials face the problem of ion release even though they meet the criteria mentioned above. As a result, the choice of metallic material to be preferred in the manufacture of hip prosthesis can be made by evaluating all these criteria among themselves and by the performances of biomaterials to be compared according to these criteria. In this study, firstly the criteria expected from the metals to be used as biomaterials have been determined. Expert opinions about the subject and criteria determined in accordance with the studies in the literature by using analytical hierarchy process have been graded according to each other. Afterwards, selection of the most appropriate material was ensured by making the order of importance according to the criteria of the candidate materials.
AtıfScopus8WoS8OpenAlex10
İncele - MakaleAçık Erişim2014Scopus SJRQ1Poly(ε-caprolactone) Composite Scaffolds Loaded with Gentamicin-Containing β-Tricalcium Phosphate/Gelatin Microspheres for Bone Tissue Engineering Applications
Sezer, Umran Aydemir; Arslantunali, Damla; Aksoy, Eda Ayse; Hasirci, Vasif; Hasirci, Nesrin
In this study, novel poly(epsilon-caprolactone) (PCL) composite scaffolds were prepared for bone tissue engineering applications, where gentamicin-loaded -tricalcium phosphate (-TCP)/gelatin microspheres were added to PCL. The effects of the amount of -TCP/gelatin microspheres added to the PCL scaffold on various properties, such as the gentamicin release rate, biodegradability, morphology, mechanical strength, and pore size distribution, were investigated. A higher amount of filler caused a reduction in the mechanical properties and an increase in the pore size and led to a faster release of gentamicin. Human osteosarcoma cells (Saos-2) were seeded on the prepared composite scaffolds, and the viability of cells having alkaline phosphatase (ALP) activity was observed for all of the scaffolds after 3 weeks of incubation. Cell proliferation and differentiation enhanced the mechanical strength of the scaffolds. Promising results were obtained for the development of bone cells on the prepared biocompatible, biodegradable, and antimicrobial composite scaffolds. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40110.
AtıfScopus25WoS22OpenAlex23İncele