Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Acar, Caner(1)
- Akgol, Kadir(1)
- Aleyna Tağıl(1)
- Aydin, Metin Mutlu(1)
- Aytac, Ali(1)
- Biter, Sedat(1)
- Coskun, Alper(1)
- Demir, Teyfik(1)
- Demirciler, Erkut(1)
- Dilek, Mehmet siddik(1)
- Disli, Ahmet Kursat(1)
- Goker, Erdem(1)
- Gunay, Banihan(1)
- Gürsoy, Pinar(1)
- Kara, Mahmut(1)
- Karataş, Şeyda Merve(1)
- Kolkiran, Nagihan(1)
- Koseci, Tolga(1)
- Kus, Fatih(1)
- Majidova, Nargiz(1)
- Menekse, Serkan(1)
- Oba, Sirin(1)
- Orman, Seval(1)
- Ozveren, Ahmet(1)
- Sahbazlar, Mustafa(1)
- Sahin, Goekhan(1)
- Sevinc, Alper(1)
- Seyyar, Mustafa(1)
- Tünbekici, Salih(1)
- Unsal, Ahmet(1)
- Yildirim, Tugce(1)
- Yucel, Hakan(1)
- Yuksel, Haydar cagatay(1)
Yayınlar
- MakaleAçık Erişim2025Regorafenib Treatment for Recurrent Glioblastoma Beyond Bevacizumab-Based Therapy: A Large, Multicenter, Real-Life Study
Tünbekici, Salih; Yuksel, Haydar cagatay; Acar, Caner; Sahin, Goekhan; Orman, Seval; Majidova, Nargiz; Coskun, Alper; Seyyar, Mustafa; Dilek, Mehmet siddik; Kara, Mahmut
Background/Objectives: In the REGOMA trial, regorafenib demonstrated an overall survival advantage over lomustine, and it has become a recommended treatment for recurrent glioblastoma in guidelines. This study aimed to evaluate the effectiveness and safety of regorafenib as a third-line treatment for patients with recurrent glioblastoma who progressed while taking bevacizumab-based therapy. Methods: This retrospective, multicenter study in Turkey included 65 patients treated between 2021 and 2023 across 19 oncology centers. The main inclusion criteria were histologically confirmed isocitrate dehydrogenase (IDH)-wildtype glioblastoma, progression after second-line bevacizumab-based treatment, and an Eastern Cooperative Oncology Group (ECOG) performance status score of <= 2. Patients received regorafenib 160 mg once daily for the first 3 weeks of each 4-week cycle. Results: The median age of the patients was 53 years (18-67 years), with a median progression-free survival of 2.5 months (95% Confidence Interval: 2.23-2.75) and a median overall survival of 4.1 months (95% CI: 3.52-4.68). The median overall survival was improved in patients who received subsequent therapy after regorafenib treatment compared with those who did not (p = 0.022). Progression-free survival was longer in patients with ECOG 0-1 than in those with ECOG 2 (p = 0.042). The safety profile was consistent with that of the REGOMA trial, with no drug-related deaths observed. Conclusions: Regorafenib shows good efficacy and safety as a third-line treatment for recurrent glioblastoma after bevacizumab-based therapy. This study supports the use of regorafenib and emphasizes the need for further randomized studies to validate its role and optimize treatment strategies.
- MakaleAçık Erişim2024Probiotics Safety Aspect of Functional Foods
Oba, Sirin; Yildirim, Tugce; Karataş, Şeyda Merve
In recent years, interest in probiotics has increased as functional foods improve quality of life and consumers become more health-conscious. The European Food Safety Authority (EFSA) has determined that all common probiotics are safe for the general population. However, this definition does not guide the outcomes of using probiotics in people with diseases that favor them, as there are no strict regulations governing applicable trademark law and the manufacture of probiotics. For this reason, Probiotics are recognized to be beneficial for the majority of patients during treatment; however, patients with weakened immune systems may be at risk for bacteremia, endocarditis, and peritonitis. There are no necessary standards regarding safety and use protocols for probiotics. More information is needed on their use before recommending probiotics to treat or prevent disease in privileged groups. These products may be considered a public health concern by reviewing information on the use of probiotics to predict the likelihood of side effects in vulnerable groups (young children, the elderly, and pregnant women).
- Yüksek Lisans TeziAçık Erişim2022Cumhuriyet Döneminde Trabzon'da güvenlik ve emniyet teşkilatı (1923-1945)
Aleyna Tağıl
Güvenlik ve emniyet teşkilatları devletlerin var olmalarını sağlayan en büyük kurumlardır. Osmanlı Devleti bu amaçla bünyesinde birçok görevli barındırmıştır ancak I. Dünya Savaşı ile iç düzen bozulmuştur. Milli Mücadele yıllarının ardından Türkiye Cumhuriyeti Anadoluda yeniden bozulan düzeni tesis etmek için çalışmıştır. Bu süreçte emniyet teşkilatlanması ise varlığını devam ettirmeyi başarmıştır. Polis, jandarma ve zabıta kurumları Osmanlı döneminde kurulup Türkiye Cumhuriyeti'ne intikal eden teşkilatlar olmuşlardır. Bu tez çalışmasında ilk olarak Osmanlı döneminde var olan emniyet yapılanmaları geniş bir şekilde ele alınarak anlatılmıştır. Ardından 1923-1945 yılları arasındaki Trabzon'daki emniyet teşkilatının işlevi, 1923 yılından öncesi ile mukayese edilerek açıklanmıştır. Bilhassa karakolların şehir içerisindeki varlıkları ve üstlendikleri rollerin yanında bölgedeki siyasi yapılanmaların emniyete katkısı, polis eğitimi noktasında yapılan emniyet çalışmaları ve toplumsal düzendeki asayiş meseleleri ele alınmıştır.
- MakaleYalnız künye2019Performance Comparison of Various Chicane Types: A Driving Simulator Study
Aydin, Metin Mutlu; Gunay, Banihan; Akgol, Kadir
Urban streets are becoming noisy, less safe and unattractive places due to high traffic volumes and vehicular speeds. Especially, high speeds causes many problems such as traffic accidents, noise, etc. To prevent these problems and negative effects of speeding, traffic calming measures have been widely used in many developed countries. In this study, the effectiveness of ten most common chicane types on speed limit compliance were examined by comparing and ranking chicanes according to their performance. For this purpose, a “Safety Index” was developed and an Ordinary Least Square Regression analysis was performed to identify safest chicane types for undivided two-lane and divided four-lane roads by using various parameters. Additionally, statistical tests were conducted to determine the most important driver characteristics of drivers before and inside the chicanes. For the analyses, all necessary data were obtained from the driving tests of 106 volunteers using a driving simulator. For the simulation scenarios, Akdeniz University’s (Antalya/Turkey) campus roads were selected as a case area. The results showed that Chicane Types 2 (CT-2) and 7 (CT-7) have the highest Safety Index values (0.69 and 0.98) and they were found to be the most proper CTs for the undivided and divided roads, respectively. From the statistical tests, it was also found that education level, gender and driving license duration were found to be the statistically significant parameters on speed choice for the most proper chicane types. Additionally, it was concluded that the most important driver characteristics are determined as age (has a negative effect) and gender (to be male has a positive effect) of drivers before and inside the chicanes. All these findings show that the investigation of different CTs has a great potential to reduce speeds and ensure safety in urban minor roads to limit vehicle speeds.