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- MakaleAçık Erişim2025Comprehensive Analysis of the Antioxidant and Enzyme Inhibitory Properties and Phenolic Compounds of Phlomis armeniaca: Potential Applicant in Neurodegenerative Diseases
Menevseoglu, Ahmed; Yılmaz, Fırat; Topal, Meryem; Topal, Fevzi
This study investigates the antioxidant and enzyme inhibitory properties of Phlomis armeniaca, a perennial plant native to the eastern and southeastern regions of Turkey. Ethanol extracts of the plant were analyzed using various bioanalytical methods, including Fe3⁺-Fe2⁺ reducing power, Cupric Reducing Antioxidant Capacity, 1,1-diphenyl-2-picryl-hydrazyl (DPPH), and 2,2-azinobis 3-ethylbenzthiazoline-6-sulfonic acid (ABTS) radical scavenging activities, as well as total phenolic and flavonoid content assessments. The results showed that P. armeniaca is rich in phenolic (38.75 ± 0.59 µg gallic acid equivalents/mg extract) and flavonoid compounds (39.34 ± 4.08 µg quercetin equivalents/mg extract). The plant demonstrated significant inhibitory effects on acetylcholinesterase (half-maximal inhibitory concentration [IC50]: 45.00 ± 0.48 mg/mL) and butyrylcholinesterase (IC50: 84.51 ± 0.84 mg/mL) enzymes, indicating its potential use in treating neurodegenerative diseases such as Alzheimer's. The study also highlighted P. armeniaca’s high chlorogenic acid, salicylic acid, 4-dihydroxybenzoic acid, and quinic acid contents, supporting its antioxidant capacity. These findings suggest that P. armeniaca could be a valuable natural resource for developing therapeutic agents to manage oxidative stress and related conditions, warranting further pharmacological exploration.
- MakaleAçık Erişim2024Determination of Antioxidant Capacities of Extracts of Sorbus subfusca (ledeb. ex. nordm.) boiss
Kocabaş, Selahattin; Topal, Fevzi
Sorbus subfusca (ledeb. ex. nordm.) boiss. (Sorbus subfusca) belongs to the Rosacese family. It is commonly referred to as highland rowan. It is an endemic species found only in the eastern Black Sea Region of Turkey and in a few countries on the Asian Continent. Both water (WESS) and ethyl alcohol (EESS) lyophilized forms were used as extracts. Different reducing capacity methods and radical scavenging activity methods were used to study the antioxidant activities of the extracts. Total phenolic compounds were calculated as 43.5 (WESS) and 43.0 (EESS) µg GAE/mg extract. This value is an indication that it can take place in plants with high phenolic content. Peroxidation inhibition percentages of linoleic acid emulsion at 20 µg mL-1 concentration for WESS and EESS; WESS was calculated as 70.93% and EESS as 82.63%. The high antioxidant capacity of Sorbus subfusca, an endemic species, brings up the preference of natural products as antioxidants. It is thought that these studies will draw a new path to the literature, especially alternative medicine and pharmacological studies.