Sürdürülebilir Kalkınma Amaçları
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- MakaleAçık Erişim2021Production and characterization of zinc oxide nanoparticles in microsystems via green synthesis; [Yeşil sentez yoluyla mikrosistemlerde çinko oksit nanopartiküllerin üretimi ve karakterizasyonu]
Akay, Şeref; Sefaoğlu, Melike
Nanoparticles (NP), which can be produced for many different fields and purposes; are at size vary from nanometer to a micrometer. These particles can be prepared by different approaches such as chemical, physical and biological methods. However, the biological approach is the most promising approach among other methods due to its simplicity and environmentally friendly conditions. The production of the nanoparticle by means of a biological approach does not require any high temperature, acidic/basic conditions and hazardous chemicals. Therefore, this method is named “green synthesis”. Development in microtechnology has had profound effects in many areas such as drug discovery, biology, diagnosis, and tissue engineering. Microfluidics which focuses on the processing of liquids in microscale systems has attracted wide attention in the production process of nanoparticles due to precise control and fast mixing. The main purpose of this study is to produce and characterize metal nanoparticles by combining microsystems and green synthesis approaches. For this purpose, in the first step, the design of microsystems that suitable for the flow of different phases was performed. In the second step, ZnO nanoparticle synthesis was carried out using the red cabbage (Brassica oleracea var.capitata f. Rubra) extracts. The synthesis of nanoparticles achieved by optimizing different parameters such as; extract: zinc ratio, zinc solution concentration, flow rates, and flow rates ratio in the microsystem and temperature. The results showed that the herbal red cabbage components can be used for the green synthesis of ZnO nanoparticles.
AtıfScopus1OpenAlex2TR Dizin1
İncele - MakaleYalnız künye2017Scopus SJRQ1An injectable alginate-based hydrogel for microfluidic applications
Akay, Seref; Heils, Rene; Trieu, Hoc Khiem; Smirnova, Irina; Yesil-Celiktas, Ozlem
The objective of this study was to develop an injectable alginate based formulation for immobilizing enzymes into microfluidic systems. The gelation was induced upon lowering the pH by addition of D-glucono-δ-lactone (GDL) and release of Ca+ ions from solid CaCO3. The effects of GDL concentration on enzymatic activity and gelation time were investigated. The results indicated that increasing the GDL concentration increased both surface area and enzymatic activity. Also, chitosan was added to the formulation at different ratios to enhance the stability of enzyme during immobilization. For microfluidic application, 100 μl spiral coil single channel microchip was fabricated and alginate GDL mixture containing β-glucosidase was injected to the microchannel prior to gelation. Enzymatic conversion was performed by pumping substrate (pNPG) through the microchannel. The results indicated that the entire substrate was converted continuously during 24 h without any leakage or deactivation of immobilized enzyme.
AtıfScopus42WoS34OpenAlex38
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