Sürdürülebilir Kalkınma Amaçları

• 1

Yazarlar

• Akgul, G.(1)
• Basbulut, E.(1)
• Celebi, M.(1)
• Mehel, D. M.(1)
• Turgut, N. F.(1)
• Yemis, T.(1)
• Özdemir, D.(1)
• Özgur, A.(1)

• MakaleYalnız künye2021Scopus SJRQ2/r/gumushane/16429
  Osteoclastic activity in chronic otitis media with cholesteatoma-related bone destruction

  Özgur, A.; Yemis, T.; Basbulut, E.; Turgut, N. F.; Özdemir, D.; Akgul, G.; Mehel, D. M.; Celebi, M.

  Background Cholesteatoma-related bone destruction is the cause of many complications due to chronic otitis media. This study aimed to evaluate osteoclastic activity in cholesteatoma-related bone destruction using tartrate-resistant acid phosphatase 5b, an enzyme specific to osteoclastic activity. Method Seventy-two patients diagnosed with chronic otitis media were included in this study and were divided into two groups: with and without bone destruction. The blood serum and tissue tartrate-resistant acid phosphatase 5b levels from both groups were compared. Results There were no significant differences in the level of serum enzymes between both groups. However, in tissue samples, tartrate-resistant acid phosphatase 5b levels were significantly lower in the bone destruction group than the group without bone destruction. Conclusion This study determined that the level of tartrate-resistant acid phosphatase 5b, a specific enzyme for osteoclastic activity in cholesteatoma-related bone destruction, is locally decreased. This data suggests that osteoclastic activity may decrease in cholesteatoma-related bone destruction. However, further experimental and clinical studies are required to clarify this highly complex mechanism.

  • 
  AtıfWoS4·OpenAlex4

  İncele