Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Baranski, Marcin(2)
- Benbrook, Charles(2)
- Burdge, Graham C.(2)
- Butler, Gillian(2)
- Calder, Philip C.(2)
- Chatzidimitriou, Eleni(2)
- Cozzi, Giulio(2)
- Eyre, Mick(2)
- Gromadzka-Ostrowska, Joanna(2)
- Jordon, Teresa(2)
- Larsen, Mette Krogh(2)
- Leifert, Carlo(2)
- Niggli, Urs(2)
- Rembialkowska, Ewa(2)
- Sakowski, Tomasz(2)
- Sanderson, Roy(2)
- Skwarlo-Sonta, Krystyna(2)
- Sotiraki, Smaragda(2)
- Srednicka-Tober, Dominika(2)
- Stefanakis, Alexandros(2)
- Steinshamn, Havard(2)
- Stergiadis, Sokratis(2)
- Stewart, Gavin(2)
- Yolcu, Halil(2)
- Ada, E.(1)
- Akgul, G.(1)
- Alkin, T.(1)
- Basbulut, E.(1)
- Can, E. Tellioglu(1)
- Capraz, N.(1)
- Celebi, M.(1)
- Ceylan, D.(1)
- Hidiroglu, C.(1)
- Mehel, D. M.(1)
- Ozalp, D. Ceylan Tufan(1)
- Sariçiçek, A.(1)
- Seal, Chris(1)
- Seal, Chris J.(1)
- Tunca, Z.(1)
- Turgut, N. F.(1)
Yayınlar
- MakaleYalnız künye2021Osteoclastic activity in chronic otitis media with cholesteatoma-related bone destruction
Özgur, A.; Yemis, T.; Basbulut, E.; Turgut, N. F.; Özdemir, D.; Akgul, G.; Mehel, D. M.; Celebi, M.
Background Cholesteatoma-related bone destruction is the cause of many complications due to chronic otitis media. This study aimed to evaluate osteoclastic activity in cholesteatoma-related bone destruction using tartrate-resistant acid phosphatase 5b, an enzyme specific to osteoclastic activity. Method Seventy-two patients diagnosed with chronic otitis media were included in this study and were divided into two groups: with and without bone destruction. The blood serum and tissue tartrate-resistant acid phosphatase 5b levels from both groups were compared. Results There were no significant differences in the level of serum enzymes between both groups. However, in tissue samples, tartrate-resistant acid phosphatase 5b levels were significantly lower in the bone destruction group than the group without bone destruction. Conclusion This study determined that the level of tartrate-resistant acid phosphatase 5b, a specific enzyme for osteoclastic activity in cholesteatoma-related bone destruction, is locally decreased. This data suggests that osteoclastic activity may decrease in cholesteatoma-related bone destruction. However, further experimental and clinical studies are required to clarify this highly complex mechanism.
- BildiriAçık Erişim2017Pressure from superiors and older age increase the risk of burnout syndrome among psychiatric trainees: A nation-wide survey in Turkey
Capraz, N.; Ozalp, D. Ceylan Tufan; Yalcin, M.; Can, E. Tellioglu; Alkin, T.
- MakaleYalnız künye2016Abnormal white matter integrity as a structural endophenotype for bipolar disorder
Sariçiçek, A.; Zorlu, N.; Yalin, N.; Hidiroglu, C.; Çavusoglu, B.; Ceylan, D.; Ada, E.; Tunca, Z.; Özerdem, A.
Background. Several lines of evidence suggest that bipolar disorder (BD) is associated with white matter (WM) pathology. Investigation of unaffected first-degree relatives of BD patients may help to distinguish structural biomarkers of genetic risk without the confounding effects of burden of illness, medication or clinical state. In the present study, we applied tract-based spatial statistics to study WM changes in patients with BD, unaffected siblings and controls. Method. A total of 27 euthymic patients with BD type I, 20 unaffected siblings of bipolar patients and 29 healthy controls who did not have any current or past diagnosis of Axis I psychiatric disorders were enrolled in the study. Results. Fractional anisotropy (FA) was significantly lower in BD patients than in the control group in the corpus callosum, fornix, bilateral superior longitudinal fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, anterior thalamic radiation, posterior thalamic radiation, cingulum, uncinate fasciculus, superior corona radiata, anterior corona radiata and left external capsule. In region-of-interest (ROI) analyses, we found that both unaffected siblings and bipolar patients had significantly reduced FA in the left posterior thalamic radiation, the left sagittal stratum, and the fornix compared with healthy controls. Average FA for unaffected siblings was intermediate between the healthy controls and bipolar patients within these ROIs. Conclusions. Decreased FA in the fornix, left posterior thalamic radiation and left sagittal stratum in both bipolar patients and unaffected siblings may represent a potential structural endophenotype or a trait-based marker for BD.
- Derleme MakaleAçık Erişim2016Higher PUFA and n-3 PUFA, conjugated linoleic acid, α-tocopherol and iron, but lower iodine and selenium concentrations in organic milk: a systematic literature review and meta- and redundancy analyses
Srednicka-Tober, Dominika; Baranski, Marcin; Seal, Chris J.; Sanderson, Roy; Benbrook, Charles; Steinshamn, Havard; Gromadzka-Ostrowska, Joanna; Rembialkowska, Ewa; Skwarlo-Sonta, Krystyna; Eyre, Mick
Demand for organic milk is partially driven by consumer perceptions that it is more nutritious. However, there is still considerable uncertainty over whether the use of organic production standards affects milk quality. Here we report results of meta-analyses based on 170 published studies comparing the nutrient content of organic and conventional bovine milk. There were no significant differences in total SFA and MUFA concentrations between organic and conventional milk. However, concentrations of total PUFA and n-3 PUFA were significantly higher in organic milk, by an estimated 7 (95% CI -1, 15)% and 56 (95% CI 38, 74) %, respectively. Concentrations of alpha-linolenic acid (ALA), very long-chain n-3 fatty acids (EPA + DPA + DHA) and conjugated linoleic acid were also significantly higher in organic milk, by an 69 (95% CI 53, 84) %, 57 (95% CI 27, 87)% and 41 ( 95% CI 14, 68) %, respectively. As there were no significant differences in total n-6 PUFA and linoleic acid (LA) concentrations, the n-6:n-3 and LA: ALA ratios were lower in organic milk, by an estimated 71 (95% CI -122, -20)% and 93 (95% CI -116, -70) %. It is concluded that organic bovine milk has a more desirable fatty acid composition than conventional milk. Meta-analyses also showed that organic milk has significantly higher alpha-tocopherol and Fe, but lower I and Se concentrations. Redundancy analysis of data from a large cross-European milk quality survey indicates that the higher grazing/conserved forage intakes in organic systems were the main reason for milk composition differences.
- Derleme MakaleAçık Erişim2016Composition differences between organic and conventional meat: a systematic literature review and meta-analysis
Srednicka-Tober, Dominika; Baranski, Marcin; Seal, Chris; Sanderson, Roy; Benbrook, Charles; Steinshamn, Havard; Gromadzka-Ostrowska, Joanna; Rembialkowska, Ewa; Skwarlo-Sonta, Krystyna; Eyre, Mick
Demand for organic meat is partially driven by consumer perceptions that organic foods are more nutritious than non-organic foods. However, there have been no systematic reviews comparing specifically the nutrient content of organic and conventionally produced meat. In this study, we report results of a meta-analysis based on sixty-seven published studies comparing the composition of organic and non-organic meat products. For many nutritionally relevant compounds (e.g. minerals, antioxidants and most individual fatty acids (FA)), the evidence base was too weak for meaningful meta-analyses. However, significant differences in FA profiles were detected when data from all livestock species were pooled. Concentrations of SFA and MUFA were similar or slightly lower, respectively, in organic compared with conventional meat. Larger differences were detected for total PUFA and n-3 PUFA, which were an estimated 23 (95% CI 11, 35)% and 47 (95% CI 10, 84)% higher in organic meat, respectively. However, for these and many other composition parameters, for which meta-analyses found significant differences, heterogeneity was high, and this could be explained by differences between animal species/meat types. Evidence from controlled experimental studies indicates that the high grazing/forage-based diets prescribed under organic farming standards may be the main reason for differences in FA profiles. Further studies are required to enable meta-analyses for a wider range of parameters (e.g. antioxidant, vitamin and mineral concentrations) and to improve both precision and consistency of results for FA profiles for all species. Potential impacts of composition differences on human health are discussed.
- DergiJOURNAL OF LARYNGOLOGY AND OTOLOGY
- DergiEUROPEAN PSYCHIATRY
- DergiPSYCHOLOGICAL MEDICINE
- DergiBRITISH JOURNAL OF NUTRITION