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- MakaleAçık Erişim2020Determining the quality of life and the sleep quality in patients with benign prostate hyperplasia
Kulakaç, Nurşen; Sayılan, Aylin Aydın
Research question: How is the quality of life and quality of sleep affected in patients with benign prostatic hyperplasia?. Research problem: The aim of this study was to evaluate the quality of life and quality of sleep in patients with benign prostatic hyperplasia (BPH) and to identify the relationship between them. Nocturia is one of the main symptoms associated to BPH, causing significant sleep disturbances, including sleep interruptions. Such sleep interruptions may significantly impair quality of life. Literature review: The assessment of nocturia and its impact on quality of life and sleep quality in patients living with benign prostatic hyperplasia (BPH) has been poor in terms of clinical research; moreover, there is a lack of specific methods to assess this impact. Methodology: The sample of this descriptive study consisted of all patients with the diagnosis of BPH who were admitted to the urology outpatient clinic of a state hospital in Turkey. The data were collected from 212 patients with BPH who accepted to participate in the study in January-June 2018. All patients gave consent prior to inclusion in the study. The Pittsburgh Sleep Quality Index and the WHOQOL-BREF (World Health Organization Quality of Life Scale - Brief Form) were used as the principle data collection tools. Percentage, t test, correlation and one-way variance analysis test were used to evaluate the data. Results: The mean age of the patients was 67.50 ± 8.89 years and 63.2% of them were first diagnosed with benign prostatic hyperplasia 2.13 years ago. The lowest and the highest average scores that the patients obtained from the WHOQOL-BREF were their social and environmental domains scores, respectively. In all, 20.2% of the patient were found to have poor sleep quality (global score ≥ 5). The results showed that there was a positive correlation between the mean scores of the sleep quality of the patients and their quality of life physical domain subscale. It was also found that there was a significant negative correlation between night urination and the sleep quality in BPH patients (P <.05). Conclusions: It was determined that low quality of life in BPH patients is associated with low sleep quality. Personal characteristics, frequent night urination and working status are important determinants of the relationship between quality of life and sleep quality.
- MakaleYalnız künye2016Increased expressions of ADAMTS-13 and apoptosis contribute to neuropathology during Toxoplasma gondii encephalitis in mice
Dincel, Gungor Cagdas; Atmaca, Hasan Tarik
Toxoplasma gondii (T. gondii) is a protozoan parasite with the potential of causing severe encephalitis among immunocompromised humans and animals. Our previous study showed that T. gondii induces high nitric oxide (NO) production, high glial activation (GFAP) and neurofilament expressions, leading to severe neurodegeneration in toxoplasma encephalitis (TE) in the central nervous system (CNS). The aim of this experimental study was to investigate ADAMTS-13 expression and apoptosis in CNS and to identify whether they have any correlation with toxoplasmosis neuropathology and neurodegeneration. Mice were infected with ME49 strain T. gondii and the levels of ADAMTS-13, caspase 3, caspase 8, caspase 9, TNFR1 and Bcl-xL expressions were examined in brain tissues by immunohistochemistry, during the development and establishment of chronic infections at 10, 30 and 60days post-infection. Results of the study revealed that the levels of ADAMTS-13 (P < 0.005), caspase 3 (P < 0.05), caspase 8 (P < 0.05), caspase 9 (P < 0.005) and TNFR1 (P < 0.05) expressions in the brain markedly increased while Bcl-xL expression decreased (P < 0.005). The most prominent finding from our study was that 10, 30 and 60days post-infection ADAMTS-13 increased significantly and this may play an important role in the regulation and protection of the blood-brain barrier integrity and CNS microenvironment in TE. These results also suggest that T. gondii-mediated apoptosis might play a pivotal role and a different type of role in the mechanism of neurodegeneration and neuropathology in the process of TE. Furthermore, expression of ADAMTS-13 might give an idea of the progress and is critical for diagnosis of this disease. To the best of the authors' knowledge, this is the first report on ADAMTS-13 expression in the CNS of T. gondii-infected mice.
- DergiNeuropathology