Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Akbas, Sinem(1)
- Aksüt, Nurhak(1)
- Akyildiz, Arif(1)
- Alan, Ozkan(1)
- Altay, Diler Us(1)
- Araz, Murat(1)
- Atacan, Huseyin(1)
- Aykan, Musa Baris(1)
- Bahar, Betül(1)
- Balci, Nilufer(1)
- Batur, Abdussamed(1)
- Bayrakci, Ismail(1)
- Beslioglu, Necla(1)
- Bilici, Ahmet(1)
- Borazan, Hale(1)
- Bostan, Sedat(1)
- Camanli, Ufuk(1)
- Cicek, Ceren Mordag(1)
- Coskun, Alper(1)
- Demir İmamoğlu, Zeynep(1)
- Ekici, Sümeyye(1)
- Engin, Esra Ozen(1)
- Erbasan, Ozan(1)
- Erdem, Tuba Berra(1)
- Erdogan, Bulent(1)
- Ertekin, Ersen(1)
- Eryigit, Umut(1)
- Feyzioglu, Bahadir(1)
- Guler, Ibrahim(1)
- Gunenc, Damla(1)
- Guren, Ali Kaan(1)
- Guven, Deniz Can(1)
- Göger, Berrin(1)
- Hamitoglu, Buket(1)
- Ilhan, Nurullah(1)
- Illeez, Ozge G.(1)
- Kahriman, Ilknur(1)
- Kara, Ismail Oguz(1)
- Karaca, Yunus(1)
- Karatas, Mevlut(1)
Yayınlar
- MakaleAçık Erişim2025Efficacy of Second-Line Treatments After Atezolizumab and Bevacizumab in Advanced Hepatocellular Carcinoma and Related Prognostic Factors: A Multicenter Study by the Turkish Oncology Group (TOG)
Majidova, Nargiz; Yaslikaya, Sendag; Mildanoglu, Maral Martin; Coskun, Alper; Uzundal, Duygu Ercan; Sahin, Taha Koray; Akyildiz, Arif; Akbas, Sinem; Camanli, Ufuk; Sahin, Elif
Background/Aims: The treatment of hepatocellular carcinoma (HCC), which accounts for 90% of all liver cancers, is highly varied. The use of second-line treatments following progression on first-line atezolizumab and bevacizumab (Atez/Bev) for advanced HCC remains controversial. The aim of this study was to analyze the real-world clinical results of second-line treatments in progression after Atez/Bev and to determine the factors affecting prognosis. Materials and Methods: Fifty-eight patients treated with second-line sorafenib, regorafenib, and cabozantinib for progression after first-line Atez/Bev for advanced/metastatic HCC from 20 centers in T & uuml;rkiye between October 2020 and June 2024 were retrospectively analyzed. Responses were evaluated by Response criteria, specifically Response Evaluation Criteria in Solid Tumors (RECIST v1.1) criteria. Median overall survival (OS) and progression-free survival (PFS) were computed with the Kaplan-Meier method. The Cox regression model was utilized to analyze multivariate analyses. Results: About 82.8% of the patients were male and the median age of the whole group was 62 (range, 18-78) years. All patients progressed after first-line Atez/Bev and were given second-line treatment. The most commonly used second-line treatment option was sorafenib (70.7%), followed by regorafenib (12.1%) and cabozantinib (10.3%). Both median PFS (4.1 months) and median OS (7.8 months) were longer in patients treated with sorafenib compared to other treatments. In univariate analyses, Child-Pugh score B, high alpha-fetoprotein (AFP) levels (>200 ng/mL), extrahepatic spread, and Prognostic Nutritional Index (PNI) < 47.6 substantially raised the risk of overall mortality. Multivariate analysis showed that extrahepatic spread (HR (Hazard ratio): 0.41, P = .012), PNI level (HR: 0.24, P = .005), and AFP level (HR:1.97, P = .049) were independent predictors of OS. Conclusion: Although second-line therapies after Atez/Bev show different degrees of efficacy, survival rates are consistent with the literature. Extrahepatic spread, AFP level, and PNI level are the main prognostic factors. In light of this information, personalized treatment strategies may improve outcomes for this challenging patient group.
- MakaleAçık Erişim2024The Effect of Smartphone Addiction on Sleep Quality and Lifestyle Behaviors of Adolescents
Göger, Berrin; Kahriman, Ilknur
Many studies highlight the negative impact of smartphone addiction on adolescents’ health. It disrupts sleep habits and lifestyle. The study was conducted to evaluate the effect of smartphone addiction on the sleep quality and lifestyle behavior of adolescents. It was conducted in public high schools in a city center in the Eastern Black Sea Region of Türkiye. The sample consisted of 546 high school students. Data were collected using a Descriptive Information Form for Adolescents, the Smartphone Addiction Scale—Short Version, the Pittsburgh Sleep Quality Index, and the Adolescent Lifestyle Profile Scale. According to the results, the incidence of smartphone addiction among adolescents differed according to gender, academic achievement, age of first smartphone (p =.044), and daily smartphone use time (p =.000). Mean Pittsburgh Sleep Quality Index scores were not significantly different for the same variables. There was a significant difference in mean Adolescent Lifestyle Profile Scale scores according to academic achievement, having a smartphone, and age of first smartphone acquisition. There was a weak positive correlation between smartphone addiction and Pittsburgh Sleep Quality Index scores and a weak negative correlation between smartphone addiction and Adolescent Lifestyle Scale scores. There was also a weak negative correlation between Pittsburgh Sleep Quality Index scores and Adolescent Lifestyle Scale scores. Smartphone addiction negatively affects adolescents’ sleep quality and lifestyle.
- MakaleAçık Erişim2023The Effect of a Musical Toy on Preschool Children’s Pain and Anxiety During Blood Collection; [Okul Öncesi Dönem Çocuklarında Kan Alma İşlemi Sırasında Işıklı Dönen Müzikli Oyuncağın Ağrı ve Anksiyeteye Etkisi]
Kurudirek, Fatma; Demir İmamoğlu, Zeynep; Ekici, Sümeyye
Objective: This study examined the effect of providing a lighted, rotating musical toy on preschool children’s pain and anxiety during a blood collection procedure. Methods: The randomized controlled study was conducted on a sample of children aged 4-6 years who applied to the blood collection unit of a state hospital in Turkey from July 1 through August 1, 2022. The data were obtained from 95 children who met the research criteria (48 in the control group and 47 in the intervention group). Stratification and block randomization methods were used to determine the experimental and control groups. The variables of gender and fear of interference were used in the stratification of the children. The Family and Child Information Form, Child Fear and Anxiety Inventory, and Wong–Baker Facial Expression Rating Scale were used to collect the data. Results: The pain scores of the children in the experimental group were found to be lower (1.42 ± 1.05) than those in the control group (2.81 ± 1.23), and the result was statistically significant (P < .001). During the procedure, the mean Child Fear and Anxiety Inventory score of the children in the experimental group (1.21 ± 0.97) was lower than that of the control group (2.72 ± 1.10), and the difference was statistically significant (P < .001). Conclusion: This study found that providing a lighted, rotating musical toy to children aged 4-6 during blood collection effectively reduced their pain and anxiety. In line with these results, it is recommended that nurses and parents use such a toy in blood collection units to reduce pain and anxiety in children.
- MakaleAçık Erişim2022Evaluation of Lower Extremity Muscles Shortness, Flexibility, and Hypermobility in Adults with Asymptomatic Sacroiliac Joint Dysfunction
Narin, Ayşe Neriman; Yazgan Dağli, Beyza; Vural Cömert, Aysun; Bahar, Betül; Özturan, Kutay Engin
Objective: (a) To investigate the presence of sacroiliac joint dysfunction in asymptomatic individuals and (b) to compare lower limb muscle shortness, flexibility of hamstring and erector spinae muscles, and hypermobility between subjects with and without asymptomatic sacroiliac joint dysfunction. Material and Methods: A total of 54 healthy young adults subjects were included in the study. The subjects were assessed with the sacroiliac joint diagnostic procedure. The seated flexion test, the standing flexion test, the Gillet test, and bilateral bony landmark examination were performed by an expert investigator. According to the positivity of at least 3 of these tests, the subjects were divided into 2 groups, the asymptomatic sacroiliac joint dysfunction group and the control group. The shortness of tensor fasciae latae and iliopsoas muscles was evaluated with the modified Ober test and the modified Thomas test. The straight leg raise test and fingertip-to-floor test were carried out for hamstring and erector spinae muscles flexibility, while hypermobility was assessed according to the Beighton criteria. Results: The asymptomatic sacroiliac joint dysfunction was diagnosed in 38% of healthy adults. There was no statistical difference in the shortness of tensor fasciae latae and iliopsoas muscles between the asymptomatic sacroiliac joint dysfunction group and the control group (P > 0.05). Similarly, there was no difference between the groups in terms of the hamstring and erector spinae muscles flexibility, and the Beighton scores (P > 0.05). Conclusion: This study emphasized that asymptomatic sacroiliac joint dysfunction might be seen in healthy young adults without the difference in shortness and flexibility in the lower extremity and hypermobility.
- MakaleAçık Erişim2017Calculation of the Index of Turkey's Vulnerability in Natural Disasters
Bostan, Sedat; Yaprak, Unal
Aim: The aim of this study was to determine the vulnerability levels of Turkey in terms of natural disasters and to guide decision makers and strategists in this field. In the study, disaster data obtained for 1987-2011 were used, and the disaster of type was most observed in our country. Materials and Methods: Data vulnerability indices against the disasters were calculated using a Data Envelopment Analysis Program (DEAP) 2.1 program with a Data envelopment analysis-based output-oriented Malmquist Total Factor Productivity Index method. Results: The regions of Turkey, which have the highest vulnerability index for the disasters, were TRA2 (0.323), TRB2 (0.305), and TRB1 (0.287) regions. In addition, it was seen that in the Black Sea region, the TR82 (0.267) region was more vulnerable than the other places of the region. In this study, a picture of the whole country over a period of 25 years in terms of disasters was captured. Conclusion: In the picture, it is seen that economic and social costs endured due to disasters are separated into two regions starting from the region of Eastern Anatolia and the north branch extends across the Black Sea region and the other south branch reaches to the Mediterranean.
- MakaleAçık Erişim2017Diagnostic Value of Cyclophilin A in Acute Ischemic Stroke
Karaca, Yunus; Tatli, Ozgur; Eryigit, Umut; Aksüt, Nurhak; Sahin, Aynur; Mentese, Ahmet; Altay, Diler Us; Beslioglu, Necla; Karatas, Mevlut; Örem, Asim
Aim: The early diagnosis and treatment of patients presenting to the emergency department symptoms of stroke can significantly reduce mortality and morbidity rates associated with it. This study aimed to investigate the diagnostic value of serum yclophilin A levels in our study group who presented to the emergency department with symptoms of acute ischemic stroke. Materials and Methods: In total, 114 patients diagnosed with acute ischemic stroke between October 2013 and October 2014 and a control group of 66 healthy volunteers were included. Cyclophilin A levels in the patient and control groups were compared. Results: The median cyclophilin A levels in the patient and control groups measured at the time of presentation were 13.47 (11.97-17.92) ng/mL and 11.54 (8.48-16.22) ng/mL, respectively. These levels were significantly higher in the patient group than in the control group (p<0.05). Conclusion: Plasma cyclophilin A levels were significantly higher in the patient group than in the control group.
- MakaleAçık Erişim2016A novel modified PAIR technique using a trocar catheter for percutaneous treatment of liver hydatid cysts: a six-year experience
Nayman, Alaaddin; Guler, Ibrahim; Keskin, Suat; Erdem, Tuba Berra; Borazan, Hale; Kucukapan, Ahmet; Ozbiner, Huseyin; Batur, Abdussamed; Ertekin, Ersen; Feyzioglu, Bahadir
PURPOSE We aimed to demonstrate the success and reliability of a novel puncture, aspiration, injection, and reaspiration (PAIR) technique in liver hydatid cysts. METHODS Percutaneous treatment with ultrasonographic guidance was performed in 493 hepatic hydatid cysts in 374 patients. Patients were treated with a new PAIR technique by single puncture method using a 6F trocar catheter. The results of this novel technique were evaluated with regards to efficacy and safety of the procedure and complication rates. RESULTS Out of 493 cysts, 317 were Gharbi type I (WHO CE 1) and 176 were Gharbi type II (WHO CE 3A). Of all cysts, 13 were referred to surgery because of cystobiliary fistulization. Recurrence was observed in 11 cysts one month later. Therefore, the success rate of the PAIR technique was 97.7% (469/480). Minor complications (fever, urticaria-like reactions, biliary fistula) were seen in 44 treated patients (12%, 44/374); the only major complication was reversible anaphylactic shock which was observed in two patients (0.5%, 2/374). CONCLUSION This novel modified PAIR technique may be superior to catheterization by Seldinger technique due to its efficiency, easier application, lower severe complication rate, and lower cost. Further comparative studies are required to confirm our observations.
- MakaleAçık Erişim2014Early and Late-Term Results of Arthroscopic Surgery on Patients with Gonarthrosis
Yilar, Sinan; Yildirim, Omer Selim
Objective: To provide guidance in the selection of the appropriate patient for arthroscopic debridement. Materials and Methods: Ninety patients who were diagnosed with gonarthrosis according to modified American College of Rheumatology (ACR) criteria and who underwent arthroscopic debridement and meniscectomy were evaluated. Functional assessment of patients was made based on preoperative as well as 1 month and 1 year postoperative results of the Lysholm Knee Score and the Visual Analog Scale (VAS). One year postoperatively, the Tapper-Hoover Scoring System was used to calculate long-term results. Analyses were conducted using SPSS 18 software. For this study ethics committee approval was received from the ethics committee of Ataturk University Medical Studies Department Head on 08.10.2010 at the 6th meeting with regards to the document written on 16.06.2010 with number 998. Results: Differences between preoperative and 1-month and 1-year postoperative values in the Western Otorino and McMaster Universities Osteoarthrosis (WOMAC) Index, Lysholm and VAS were found to be statistically significant (p<0.001) (Table 1). According to TapperHoover results, 82.8% of patients benefited from arthroscopic debridement in the long term (Table 2). Among body mass index (BMI) groups, the WOMAC, Lysholm and VAS values of obese patients were worse than those of normal weight and underweight patients, and the difference was statistically significant (p<0.005). Late-term results of patients younger than 55 were superior to those over 55. Conclusion: In the treatment of patients with gonarthrosis, arthroscopic debridement is a good option. Patients who have a low BMI and are younger than 55 years old experience more benefit from arthroscopic debridement.
- MakaleYalnız künye2012Endovenous ablation with a 940 nm laser for the treatment of great saphenous vein insufficiency: short- to mid-term results
Memetoglu, Mehmet Erdem; Kurtcan, Serpil; Erbasan, Ozan; Özel, Deniz
PURPOSE We aimed to present the short- to mid-term results of endovenous laser ablation (EVLA) procedures that were used to treat great saphenous vein (GSV) insufficiency. MATERIALS AND METHODS This prospective study was conducted between December 2009 and January 2011. A total of 112 incompetent GSVs were treated using EVLA with a 940 nm wavelength laser. Ninety patients were treated for varicose veins with saphenous reflux, including 36 females (40%) and 54 males (60%). These patients' ages ranged from 17 to 79 years (median, 48 years). After the EVLA, the patients were monitored using duplex ultrasonography and were assessed clinically at 1 week and 1, 3, 6, and 12 months after the surgery. The patients were scheduled for a three-day examination after the EVLA to assess the level of pain that each patient was experiencing in each limb. RESULTS At the end of a one-year follow-up period, the postprocedural duplex scans revealed a total occlusion of the treated GSVs in 88 (97%) patients and a sub-total occlusion in two (2%) patients. The average modified clinical, etiological, anatomical, and pathological score was significantly decreased at 12 months. The following complications were observed in the present study: hypoesthesia (11%), swelling and induration (5%), skin pigmentation (5%), deep vein thrombosis (1%), erythema (1%), and bleeding (1%). The mean visual analog pain score for the entire procedure was 3.14 +/- 1.06. CONCLUSION Our short- and mid-term results of the EVLA procedure were satisfactory, and the results of this study reaffirmed the safety and effectiveness of an EVLA using a 940 nm wavelength for the treatment of GSV insufficiency.
- MakaleAçık Erişim2010The Relationship Between Knee Osteoarthritis and Osteoporosis
Sezer, Ilhan; Illeez, Ozge G.; Tuna, Serpil D.; Balci, Nilufer
Objective: The aim of this study was to investigate the association between knee osteoarthritis (OA) and bone mineral density (BMD) in the femur and lumbar vertebrae. Materials and Methods: A total of 74 female patients (mean age 61.9 +/- 9.1 years, mean body mass index 27.09 +/- 4.24) diagnosed with knee OA were included in this study. To assess knee OA, bilateral weight-bearing antero-posterior knee radiographs were taken and graded from 0 to 4 according to Kellgren-Lawrence criteria. The BMD of the subjects was measured using dual-energy X-ray absorptiometry (DEXA). BMD measurements of those with OA were compared with those without OA. Results: While there was no correlation between BMD and the grade of knee OA, a significant negative correlation was found between age and femur BMD. Body mass index was positively correlated with OA and negatively correlated with OP. Conclusion: Further investigations are needed to demonstrate the association between knee OA and BMD.
- DergiEURASIAN JOURNAL OF MEDICINE
- DergiArchives of Health Science and Research
- DergiAddicta: the Turkish Journal on Addictions
- DergiTURKISH JOURNAL OF GASTROENTEROLOGY
- DergiDIAGNOSTIC AND INTERVENTIONAL RADIOLOGY