Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleYalnız künye2016Systemic oxidant/antioxidant balance in human abdominal aortic aneurysm
Menteşe, Umit; Turan, Ibrahim; Usta, Sefer; Demir, Selim; Koral, Özgür; Öztaş Menteşe, Seda; Çavuşoǧlu, Ismail Gökhan; Karahan, Süleyman Caner; Alver, Ahmet; Doǧan, Orhan Veli
The aim of this study was to evaluate the oxidant-antioxidant balance in patients with abdominal aortic aneurysms (AAA). Forty-two consecutive patients with AAA and 46 control subjects were included. Total oxidant status (TOS) and total antioxidant status (TAS) levels were measured and the oxidative stress index (OSI) value determined. Serum TOS and OSI values in patients with AAA were higher than those in the controls (p<0.001, p<0.001, respectively). There was a positive correlation between abdominal aortic diameters, serum TOS levels (r=0.592, p<0.001) and OSI values (r=0.598, p<0.001). A cut-off value of 17.68 μmol H2O2 equivalent/L for TOS was associated with 86% sensitivity and 83% specificity and a cut-off value of 1.77 for OSI was associated with 86% sensitivity and 81% specificity for predicting AAA. Systemic oxidative imbalance develops in patients with AAA, particularly as a result of an increase in TOS.
- MakaleYalnız künye2015On- pump koroner arter baypas greftlemede miyokarde nfarktüsü ile iskemi modifiye albüminin ilişkisi
Usta, Sefer; Doğan, Orhan Veli; Doğan, Süheyla; Demirbaş, Mine; Karahan, Süleyman Caner; Kılıç, Aşkın; Menteşe, Ümit; Aykan, Ahmet Çağrı; Turan, İbrahim; Demir, Selim
Background:­ This study aims to evaluate the potential ofischemia-modified albumin (IMA) to predict the myocardialinfarction in on pump coronary artery bypass grafting(ONCABG) patients.Methods: Fifty elective isolated ONCABG patients (41 males,9 females; mean age 66 years; range 56 to 75 years) were includedin the study. Patients were divided into perioperative myocardialinfarction (PMI; n=8) and non-infarction (NPMI; n=42) groupsaccording to perioperative cardiac troponin I (cTnI) values andECG findings. Serum IMA levels were measured preoperatively,20 minutes after aortic cross clamping, 30 minutes, at 3, 6,12 and 24 hours after declamping.Results:­ Compared to the NPMI group, the declamping 30minutes, 3, 6 and 12 hours IMA levels were higher in the PMIgroup (p=0.002, p=0.048, p=0.023, p=0.007, respectively). Inboth NPMI and PMI groups, the 20 minutes after aortic crossclamping IMA levels were higher compared to the preoperativeIMA levels (p=0.0001, p=0.038, respectively).Conclusion:­ Our study results show that IMA may be anearly marker of myocardial infarction in the ONCABGpatients.
- MakaleAçık Erişim2015Comparison of perioperative oxidative stress in endovascular and open repair of abdominal aortic aneurysm
Doğan, Orhan Veli; Menteşe, Ümit; Doğan, Süheyla; Usta, Sefer; Turan, İbrahim; Haliloğlu, Ergün; Karahan, Süleyman Caner
Background/aim: To investigate the differences in perioperative oxidative stress (OS) in abdominal aortic aneurysm (AAA) patients treated with either endovascular repair (EVAR) or open repair (OR).; Materials and methods: Twenty patients (11 OR, 9 EVAR) treated for AAA with no known malignant or inflammatory disease and an aneurysm diameter of over 5 cm and no rupture were included in the study. Blood samples were obtained preoperatively, during aortic occlusion, and 1 h and 24 h after reperfusion. Total antioxidant status (TAS), total oxidative stress (TOS), and malondialdehyde (MDA) levels were measured and oxidative stress index (OSI) was calculated.; Results: OSI at 1 h and 24 h after reperfusion was higher in the EVAR group (P = 0.004 and P = 0.002, respectively). TAS levels were higher (P = 0.001, P = 0,029). MDA levels showed no difference (P = 0.291, P = 0.076). TOS levels were lower 24 h after reperfusion in the EVAR group (P = 0.018). Conclusion: Markers of oxidative stress were lower in the EVAR group. This may be associated with advantages of EVAR. More studies are required for a clear-cut conclusion.
- MakaleYalnız künye2015The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting
Mentese, Umit; Dogan, Orhan Veli; Dogan, Suheyla; Turan, Ibrahim; Usta, Sefer; Demirbas, Mine; Aykan, Ahmet Cagri; Kiliç, Askin; Demir, Selim; Karahan, Suleyman Caner
Background: This study aims to evaluate the potential of ischemia-modified albumin (IMA) to predict the myocardial infarction in on pump coronary artery bypass grafting (ONCABG) patients. Methods: Fifty elective isolated ONCABG patients (41 males, 9 females; mean age 66 years; range 56 to 75 years) were included in the study. Patients were divided into perioperative myocardial infarction (PMI; n=8) and non-infarction (NPMI; n=42) groups according to perioperative cardiac troponin I (cTnI) values and ECG findings. Serum IMA levels were measured preoperatively, 20 minutes after aortic cross clamping, 30 minutes, at 3, 6, 12 and 24 hours after declamping. Results: Compared to the NPMI group, the declamping 30 minutes, 3, 6 and 12 hours IMA levels were higher in the PMI group (p=0.002, p=0.048, p=0.023, p=0.007, respectively). In both NPMI and PMI groups, the 20 minutes after aortic cross clamping IMA levels were higher compared to the preoperative IMA levels (p=0.0001, p=0.038, respectively). Conclusion: Our study results show that IMA may be an early marker of myocardial infarction in the ONCABG patients.
- MakaleAçık Erişim2014Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting
Mentese, Umit; Dogan, Orhan Veli; Turan, Ibrahim; Usta, Sefer; Dogan, Emre; Mentese, Seda Oztas; Demir, Selim; Ozer, Tanil; Aykan, Ahmet Cagri; Alver, Ahmet
Backround. The aim of this study was to evaluate the changes in perioperative oxidant-antioxidant balance in ONCABG. Methods. Twenty-three patients were included in this study. Serum total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values were assessed preoperatively, at 20 minutes after aortic clamping and at 30 minutes, 6 hours, and 48 hours after declamping (reperfusion). The patients were divided into 2 groups according to the median aortic cross clamping (XC) time: group 1 (XC time < 42 minutes) and group 2 (XC time >= 42 minutes). Results. TOS and OSI values of whole patients at 30 minutes after reperfusion were higher than preoperative values (P = 0.045, P = 0.015), while perioperative TAS levels of the patients were similar to the preoperative levels (P = 0.173). XC time was correlated with TOS levels at 30 minutes after reperfusion (P = 0.43, P = 0.041). In group 2, TOS and OSI values at 30 minutes after reperfusion were higher than preoperative values (P = 0.023, P = 0.048), whereas a significant difference was not found in group 1 (P = 0.601, P = 0.327). Conclusions. Oxidative imbalance and increase in TOS at reperfusion in ONCABG may be associated with XC time.