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- MakaleAçık Erişim2026Adherence to the MIND Diet and Its Effect on Glycemic Parameters in Patients with Type 2 Diabetes: A Cross-Sectional Study; [Tip 2 Diyabetlilerde MIND Diyetine Uyumun Glisemik Parametreler Üzerindeki Etkisi: Kesitsel Bir Çalışma]
Koçyiğit, Emine; Koçak, Tevfik; Özbek, Yağmur Demirel
Aim: This study aimed to assess the relationship between Mediterranean-Dietary Approach to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet score and indicators of glucose control and lipid metabolism in patients with type 2 diabetes mellitus. Methods: This cross-sectional study involved 459 patients diagnosed with type 2 diabetes mellitus aged 20-64 years. Patients with type 2 diabetes mellitus completed a general information form and anthropometric measures. The MIND diet scores obtained from the MIND diet components form. The biochemical parameters gathered from individuals over the last three months were documented. Results: The mean age and body mass index in the study population were 49.10±10.10 years and 30.62±5.48 kg/m2. Overall, the mean MIND diet score was 8.64±1.75, and 47.10% had high adherence to the MIND diet. A significant difference was found between HbA1c and fasting plasma glucose (FBG) in the MIND groups, as well as a substantial negative association identified among HbA1c, FBG, and MIND scores. Conclusions: This study emphasized the significant incidence of overweight and obesity among Turkish adults with type 2 diabetes mellitus. Higher adherence to the MIND diet is associated with better glycemic control. Higher MIND diet scores associated with reduced HbA1c and FBG levels. However, no significant associations with the parameters of lipid metabolism were found. By emphasizing nutrient-dense foods and supporting both metabolic and psychological health, the MIND diet may represent a valuable adjunct to conventional diabetes management. Keywords.
- Derleme MakaleAçık Erişim2024Oxylipins Derived from PUFAs in Cardiometabolic Diseases: Mechanism of Actions and Possible Nutritional Interactions
Ağagündüz, Duygu; Yeşildemir, Özge; Koçyiğit, Emine; Koçak, Tevfik; Özen Ünaldı, Buket; Ayakdaş, Gamze; Budán, Ferenc
Oxylipins are oxidized fatty acids, both saturated and unsaturated, formed through pathways that involve singlet oxygen or dioxygen-mediated oxygenation reactions and are primarily produced by enzyme families such as cyclooxygenases, lipoxygenases, and cytochrome P450. These lipid-based complex bioactive molecules are pivotal signal mediators, acting in a hormone-like manner in the pathophysiology of numerous diseases, especially cardiometabolic diseases via modulating plenty of mechanisms. It has been reported that omega-6 and omega-3 oxylipins are important novel biomarkers of cardiometabolic diseases. Moreover, collected literature has noted that diet and dietary components, especially fatty acids, can modulate these oxygenated lipid products since they are mainly derived from dietary omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) or linoleic acid and α-linolenic by elongation and desaturation pathways. This comprehensive review aims to examine their correlations to cardiometabolic diseases and how diets modulate oxylipins. Also, some aspects of developing new biomarkers and therapeutical utilization are detailed in this review.